(39 nodes) Pancreas development network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HNF1B	HNF1 homeobox B. (558 aa)
	PROX1	Prospero homeobox 1. (782 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (643 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (480 aa)
	FOXA2	Forkhead box A2. (459 aa)
	RBM4	RNA binding motif protein 4. (366 aa)
	ALDH1A2	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
	PTF1A	Pancreas associated transcription factor 1a. (335 aa)
	PDX1	Homeobox domain-containing protein. (290 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1104 aa)
	BMP6	Bone morphogenetic protein 6. (534 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (455 aa)
	RFX6	Regulatory factor X6. (930 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (756 aa)
	NKX6-1	NK6 homeobox 1. (376 aa)
	SELENOT	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
	CCDC39	Coiled-coil domain containing 39. (935 aa)
	GIPR	Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (452 aa)
	MNX1	Motor neuron and pancreas homeobox 1. (388 aa)
	IL6R	Interleukin-6 receptor alpha. (467 aa)
	PAX6	Paired box 6. (221 aa)
	GIP	GLUCAGON domain-containing protein. (144 aa)
	NPHP3	TPR_REGION domain-containing protein. (1334 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (390 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (734 aa)
	GATA6	GATA binding protein 6. (651 aa)
	NKX3-2	NK3 homeobox 2. (323 aa)
	SRP54-2	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (488 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	BAK1	BCL2 antagonist/killer 1. (204 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	RFX3	Regulatory factor X3. (753 aa)
	F6UZL6_MONDO	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (129 aa)
	CCDC40	Uncharacterized protein. (1088 aa)
	ANXA1	Annexin. (346 aa)
	WFS1	Wolframin ER transmembrane glycoprotein. (878 aa)
	HNF1A	HNF1 homeobox A. (613 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC39	CCDC40	ENSMODP00000026621	ENSMODP00000002639	Coiled-coil domain containing 39.	Uncharacterized protein.	0.750
CCDC39	DNAAF1	ENSMODP00000026621	ENSMODP00000006081	Coiled-coil domain containing 39.	Dynein assembly factor 1, axonemal.	0.575
CCDC40	CCDC39	ENSMODP00000002639	ENSMODP00000026621	Uncharacterized protein.	Coiled-coil domain containing 39.	0.750
CCDC40	DNAAF1	ENSMODP00000002639	ENSMODP00000006081	Uncharacterized protein.	Dynein assembly factor 1, axonemal.	0.591
CTNNB1	DLL1	ENSMODP00000014004	ENSMODP00000049507	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.425
CTNNB1	SMO	ENSMODP00000014004	ENSMODP00000018347	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.473
DLL1	CTNNB1	ENSMODP00000049507	ENSMODP00000014004	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Catenin beta 1.	0.425
DNAAF1	CCDC39	ENSMODP00000006081	ENSMODP00000026621	Dynein assembly factor 1, axonemal.	Coiled-coil domain containing 39.	0.575
DNAAF1	CCDC40	ENSMODP00000006081	ENSMODP00000002639	Dynein assembly factor 1, axonemal.	Uncharacterized protein.	0.591
EIF2AK3	WFS1	ENSMODP00000012052	ENSMODP00000003437	Eukaryotic translation initiation factor 2 alpha kinase 3.	Wolframin ER transmembrane glycoprotein.	0.403
FOXA2	GATA6	ENSMODP00000007701	ENSMODP00000052081	Forkhead box A2.	GATA binding protein 6.	0.640
FOXA2	HNF1A	ENSMODP00000007701	ENSMODP00000003604	Forkhead box A2.	HNF1 homeobox A.	0.688
FOXA2	IHH	ENSMODP00000007701	ENSMODP00000019154	Forkhead box A2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.470
FOXA2	PAX6	ENSMODP00000007701	ENSMODP00000034398	Forkhead box A2.	Paired box 6.	0.660
FOXA2	PDX1	ENSMODP00000007701	ENSMODP00000011240	Forkhead box A2.	Homeobox domain-containing protein.	0.701
FOXA2	SHH	ENSMODP00000007701	ENSMODP00000006183	Forkhead box A2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.470
GATA6	FOXA2	ENSMODP00000052081	ENSMODP00000007701	GATA binding protein 6.	Forkhead box A2.	0.640
GATA6	HNF1A	ENSMODP00000052081	ENSMODP00000003604	GATA binding protein 6.	HNF1 homeobox A.	0.423
GATA6	PTF1A	ENSMODP00000052081	ENSMODP00000011152	GATA binding protein 6.	Pancreas associated transcription factor 1a.	0.494
GIP	GIPR	ENSMODP00000040611	ENSMODP00000031034	GLUCAGON domain-containing protein.	Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family.	0.998