STRINGSTRING
CDK12 CDK12 F6WG96_MONDO F6WG96_MONDO GTF2F1 GTF2F1 CCNT2 CCNT2 LEO1 LEO1 ERCC6 ERCC6 ALYREF ALYREF NELFA NELFA HNRNPU HNRNPU SUPT16H SUPT16H RECQL5 RECQL5 PWWP2A PWWP2A THOC5 THOC5 ZC3H4 ZC3H4 CTNNB1 CTNNB1 MED8 MED8 LDB1 LDB1 WDR82 WDR82 CDC73 CDC73 CDK13 CDK13 CCNK CCNK EAPP EAPP EAF1 EAF1 NELFE NELFE WDR43 WDR43 NELFCD NELFCD NELFB NELFB ELL3 ELL3 EAF2 EAF2 RNF168 RNF168 SUPT6H SUPT6H ELL2 ELL2 THOC1 THOC1 CCAR2 CCAR2 EZH2 EZH2 LOC100032661 LOC100032661 F6VDP4_MONDO F6VDP4_MONDO ENSMODP00000059264 ENSMODP00000059264 SETD5 SETD5 ENSMODP00000058852 ENSMODP00000058852 BRD4 BRD4 ELL ELL SCAF8 SCAF8 ENSMODP00000056929 ENSMODP00000056929 ENSMODP00000056680 ENSMODP00000056680 ENSMODP00000055602 ENSMODP00000055602 KAT7 KAT7 ZNF326 ZNF326 ENSMODP00000053114 ENSMODP00000053114 RNF8 RNF8 ENSMODP00000049180 ENSMODP00000049180 MED8-2 MED8-2 ENSMODP00000048274 ENSMODP00000048274 SUPT5H SUPT5H ZMYND11 ZMYND11 SUPT4H1 SUPT4H1 ENSMODP00000042313 ENSMODP00000042313 ENSMODP00000042001 ENSMODP00000042001 CCNT1 CCNT1 AXIN1 AXIN1 CDK9 CDK9 K7E0A4_MONDO K7E0A4_MONDO F7C0L7_MONDO F7C0L7_MONDO F6RQE0_MONDO F6RQE0_MONDO F6YRI3_MONDO F6YRI3_MONDO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK12Protein kinase domain-containing protein. (1499 aa)
F6WG96_MONDOTranscription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (243 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (243 aa)
CCNT2Uncharacterized protein; Belongs to the cyclin family. (731 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (668 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1492 aa)
ALYREFAly/REF export factor. (265 aa)
NELFANegative elongation factor complex member A. (541 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (837 aa)
SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (970 aa)
PWWP2APWWP domain containing 2A. (602 aa)
THOC5THO complex 5. (685 aa)
ZC3H4Zinc finger CCCH-type containing 4. (1212 aa)
CTNNB1Catenin beta 1. (781 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (287 aa)
LDB1LIM domain binding 1. (411 aa)
WDR82WD_REPEATS_REGION domain-containing protein. (313 aa)
CDC73CDC73_N domain-containing protein. (371 aa)
CDK13Cyclin dependent kinase 13. (1378 aa)
CCNKCyclin K; Belongs to the cyclin family. (580 aa)
EAPPE2F associated phosphoprotein. (284 aa)
EAF1ELL associated factor 1. (259 aa)
NELFENegative elongation factor complex member E. (400 aa)
WDR43WD repeat domain 43. (682 aa)
NELFCDNegative elongation factor complex member C/D. (592 aa)
NELFBNegative elongation factor complex member B. (580 aa)
ELL3Elongation factor for RNA polymerase II 3. (385 aa)
EAF2ELL associated factor 2. (262 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (572 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
ELL2Elongation factor for RNA polymerase II 2. (647 aa)
THOC1THO complex 1. (665 aa)
CCAR2Cell cycle and apoptosis regulator 2. (849 aa)
EZH2Uncharacterized protein. (665 aa)
LOC100032661Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (117 aa)
F6VDP4_MONDOTranscription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (105 aa)
ENSMODP00000059264Uncharacterized protein. (264 aa)
SETD5SET domain containing 5. (1518 aa)
ENSMODP00000058852Uncharacterized protein. (820 aa)
BRD4Uncharacterized protein. (692 aa)
ELLElongation factor for RNA polymerase II. (629 aa)
SCAF8SR-related CTD associated factor 8. (1270 aa)
ENSMODP00000056929CYCLIN domain-containing protein; Belongs to the cyclin family. (172 aa)
ENSMODP00000056680Uncharacterized protein. (83 aa)
ENSMODP00000055602Uncharacterized protein. (451 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (614 aa)
ZNF326Zinc finger protein 326; Belongs to the AKAP95 family. (529 aa)
ENSMODP00000053114Uncharacterized protein. (289 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (497 aa)
ENSMODP00000049180Protein kinase domain-containing protein. (266 aa)
MED8-2Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (136 aa)
ENSMODP00000048274WD_REPEATS_REGION domain-containing protein. (74 aa)
SUPT5HTranscription elongation factor SPT5. (1041 aa)
ZMYND11Zinc finger MYND-type containing 11. (564 aa)
SUPT4H1Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (117 aa)
ENSMODP00000042313Uncharacterized protein. (84 aa)
ENSMODP00000042001MARVEL domain-containing protein. (493 aa)
CCNT1Cyclin T1. (590 aa)
AXIN1Axin 1. (875 aa)
CDK9Cyclin dependent kinase 9. (508 aa)
K7E0A4_MONDOUncharacterized protein. (667 aa)
F7C0L7_MONDOWD_REPEATS_REGION domain-containing protein. (333 aa)
F6RQE0_MONDOChromo domain-containing protein. (148 aa)
F6YRI3_MONDOUncharacterized protein. (647 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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