STRINGSTRING
AKT3 AKT3 PPARG PPARG PARP1 PARP1 SLC27A4 SLC27A4 GRB14 GRB14 USF1 USF1 GCLC GCLC ENSMODP00000059959 ENSMODP00000059959 ENSMODP00000059954 ENSMODP00000059954 INHBB INHBB GSK3B GSK3B IGF1R IGF1R WDTC1 WDTC1 PDK4 PDK4 ENSMODP00000058342 ENSMODP00000058342 PRKDC PRKDC RAB13 RAB13 C2CD5 C2CD5 ENSMODP00000053891 ENSMODP00000053891 PTPN2 PTPN2 EIF4EBP1 EIF4EBP1 ENSMODP00000052394 ENSMODP00000052394 PCK2 PCK2 CPEB2 CPEB2 ENSMODP00000051155 ENSMODP00000051155 ENSMODP00000049947 ENSMODP00000049947 GPLD1 GPLD1 ZNF106 ZNF106 FOXO4 FOXO4 GCK GCK PTPRA PTPRA EPRS1 EPRS1 SORBS1 SORBS1 INPP5K INPP5K BCAR3 BCAR3 ZDHHC7 ZDHHC7 SLC27A1 SLC27A1 DENND4C DENND4C PCSK9 PCSK9 RARRES2 RARRES2 GOT1 GOT1 CAPN10 CAPN10 CPEB1 CPEB1 TBC1D4 TBC1D4 RHOQ RHOQ CYFIP1 CYFIP1 INSIG1 INSIG1 APPL1 APPL1 CAV2 CAV2 LEP LEP ENSMODP00000044573 ENSMODP00000044573 PHIP PHIP INSRR INSRR LPIN3 LPIN3 TRIB3 TRIB3 INSIG2 INSIG2 ENSMODP00000042333 ENSMODP00000042333 ENSMODP00000042309 ENSMODP00000042309 PRKCZ PRKCZ K7E4A5_MONDO K7E4A5_MONDO K7E1M2_MONDO K7E1M2_MONDO SREBF1 SREBF1 IRS2 IRS2 F6TU13_MONDO F6TU13_MONDO LPIN2 LPIN2 IRS1 IRS1 SOGA1 SOGA1 LOC100617582 LOC100617582 RAB12 RAB12 RAB31 RAB31 GHSR GHSR GHRHR GHRHR H9H7J4_MONDO H9H7J4_MONDO H9H7J2_MONDO H9H7J2_MONDO SLC2A8 SLC2A8 PIK3R1 PIK3R1 F7AH78_MONDO F7AH78_MONDO F6QD61_MONDO F6QD61_MONDO PKLR PKLR PDPK1 PDPK1 PCK1 PCK1 PTPN1 PTPN1 PRKCI PRKCI RAB10 RAB10 INSR INSR STXBP4 STXBP4 SLC9A1 SLC9A1 NCOA5 NCOA5 AKT1 AKT1 ADIPOQ ADIPOQ APC APC EIF4EBP2 EIF4EBP2 PDK2 PDK2 F6V0Y2_MONDO F6V0Y2_MONDO SRSF5 SRSF5 RB1 RB1 LPIN1 LPIN1 TRARG1 TRARG1 GH1 GH1 RAB15 RAB15 ERRFI1 ERRFI1 GRB10 GRB10 CSRP3 CSRP3 XBP1 XBP1 SLC29A2 SLC29A2 DNAI1 DNAI1 EEF2K EEF2K AKT2 AKT2 GRB2 GRB2 PDE3B PDE3B RPS6KB1 RPS6KB1 SLC2A4 SLC2A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (486 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
SLC27A4Solute carrier family 27 member 4. (649 aa)
GRB14Growth factor receptor bound protein 14. (552 aa)
USF1Upstream transcription factor 1. (310 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
ENSMODP00000059959AGC-kinase C-terminal domain-containing protein. (64 aa)
ENSMODP00000059954Uncharacterized protein. (554 aa)
INHBBInhibin subunit beta B. (374 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
WDTC1WD and tetratricopeptide repeats 1. (740 aa)
PDK4Protein-serine/threonine kinase. (423 aa)
ENSMODP00000058342DUF3496 domain-containing protein. (525 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4010 aa)
RAB13Uncharacterized protein. (140 aa)
C2CD5C2 calcium dependent domain containing 5. (1038 aa)
ENSMODP00000053891Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (138 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (403 aa)
EIF4EBP1Uncharacterized protein. (273 aa)
ENSMODP00000052394Protein kinase domain-containing protein. (279 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (553 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (1072 aa)
ENSMODP00000051155Uncharacterized protein. (54 aa)
ENSMODP00000049947Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (496 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (900 aa)
ZNF106Zinc finger protein 106. (1989 aa)
FOXO4FOXO-TAD domain-containing protein. (350 aa)
GCKPhosphotransferase. (532 aa)
PTPRAProtein tyrosine phosphatase receptor type A. (876 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1598 aa)
SORBS1Sorbin and SH3 domain containing 1. (1277 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (465 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (826 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (278 aa)
SLC27A1Solute carrier family 27 member 1. (647 aa)
DENND4CDENN domain containing 4C. (1663 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (618 aa)
RARRES2Retinoic acid receptor responder 2. (172 aa)
GOT1Aspartate aminotransferase. (466 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (676 aa)
CPEB1Uncharacterized protein. (490 aa)
TBC1D4TBC1 domain family member 4. (1090 aa)
RHOQRas homolog family member Q. (205 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (662 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ENSMODP00000044573Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
PHIPPleckstrin homology domain interacting protein. (1846 aa)
INSRRTyrosine-protein kinase receptor. (1307 aa)
LPIN3LNS2 domain-containing protein. (741 aa)
TRIB3Protein kinase domain-containing protein. (146 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
ENSMODP00000042333Uncharacterized protein. (76 aa)
ENSMODP00000042309IRS-type PTB domain-containing protein. (534 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (589 aa)
K7E4A5_MONDOANK_REP_REGION domain-containing protein. (589 aa)
K7E1M2_MONDOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1138 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (984 aa)
IRS2Insulin receptor substrate 2. (1384 aa)
F6TU13_MONDOProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
LPIN2Lipin 2. (848 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1420 aa)
LOC100617582Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1107 aa)
RAB12RAB12, member RAS oncogene family. (338 aa)
RAB31Uncharacterized protein. (191 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)
GHRHRUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (700 aa)
H9H7J4_MONDOUncharacterized protein. (1180 aa)
H9H7J2_MONDOANK_REP_REGION domain-containing protein. (859 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (485 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
F7AH78_MONDOBSD domain-containing protein. (269 aa)
F6QD61_MONDOBSD domain-containing protein. (352 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (569 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (455 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (391 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (579 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
STXBP4Syntaxin binding protein 4. (580 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (392 aa)
NCOA5Nuclear receptor coactivator 5. (629 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (256 aa)
APCAPC regulator of WNT signaling pathway. (2936 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (122 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
F6V0Y2_MONDOUncharacterized protein. (1158 aa)
SRSF5Serine and arginine rich splicing factor 5. (266 aa)
RB1RB transcriptional corepressor 1. (937 aa)
LPIN1Uncharacterized protein. (596 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (177 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. (215 aa)
RAB15RAB15, member RAS oncogene family. (212 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (469 aa)
GRB10Growth factor receptor bound protein 10. (596 aa)
CSRP3Cysteine and glycine rich protein 3. (232 aa)
XBP1X-box binding protein 1. (204 aa)
SLC29A2Solute carrier family 29 member 2. (448 aa)
DNAI1Dynein axonemal intermediate chain 1. (698 aa)
EEF2KEukaryotic elongation factor 2 kinase. (724 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDE3BPhosphodiesterase. (1156 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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