(26 nodes) Sarcoplasmic reticulum membrane network (Monodelphis domestica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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Your Input:
	NOS1AP	PID domain-containing protein. (705 aa)
	AKAP6	A-kinase anchoring protein 6. (2333 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (948 aa)
	FKBP1A	Peptidylprolyl isomerase. (108 aa)
	F6TTE4_MONDO	PID domain-containing protein. (203 aa)
	TMEM109	Transmembrane protein 109. (260 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	RTN2	Reticulon. (439 aa)
	F6XCF5_MONDO	Peptidylprolyl isomerase. (103 aa)
	KLHL41	Kelch like family member 41. (948 aa)
	DHRS7C	Dehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (383 aa)
	ENSMODP00000045422	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (763 aa)
	RYR2	Ryanodine receptor 2. (4900 aa)
	STIM1	Stromal interaction molecule 1. (776 aa)
	CHERP	Calcium homeostasis endoplasmic reticulum protein. (946 aa)
	SYNE2	Spectrin repeat containing nuclear envelope protein 2. (6528 aa)
	LOC100029733	Peptidylprolyl isomerase. (101 aa)
	RYR3	Ryanodine receptor 3. (4841 aa)
	SRL	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (472 aa)
	ATP2A2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
	TRDN	Uncharacterized protein. (275 aa)
	TMEM38A	Transmembrane protein 38A. (303 aa)
	RYR1	Ryanodine receptor 1. (4131 aa)
	REEP5	Receptor expression-enhancing protein. (189 aa)
	SRI	Sorcin. (234 aa)
	FKBP1B	Peptidylprolyl isomerase. (108 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP6	RYR1	ENSMODP00000021971	ENSMODP00000016617	A-kinase anchoring protein 6.	Ryanodine receptor 1.	0.403
AKAP6	RYR2	ENSMODP00000021971	ENSMODP00000046276	A-kinase anchoring protein 6.	Ryanodine receptor 2.	0.754
ATP2A1	ATP2A2	ENSMODP00000019420	ENSMODP00000054285	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.908
ATP2A1	ENSMODP00000045422	ENSMODP00000019420	ENSMODP00000045422	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.904
ATP2A1	PLN	ENSMODP00000019420	ENSMODP00000029517	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.988
ATP2A1	RYR1	ENSMODP00000019420	ENSMODP00000016617	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 1.	0.742
ATP2A1	SRL	ENSMODP00000019420	ENSMODP00000053021	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.607
ATP2A1	TRDN	ENSMODP00000019420	ENSMODP00000054571	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Uncharacterized protein.	0.468
ATP2A2	ATP2A1	ENSMODP00000054285	ENSMODP00000019420	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.908
ATP2A2	ENSMODP00000045422	ENSMODP00000054285	ENSMODP00000045422	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.904
ATP2A2	PLN	ENSMODP00000054285	ENSMODP00000029517	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.990
ATP2A2	RYR1	ENSMODP00000054285	ENSMODP00000016617	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 1.	0.481
ATP2A2	RYR2	ENSMODP00000054285	ENSMODP00000046276	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 2.	0.618
ATP2A2	SRL	ENSMODP00000054285	ENSMODP00000053021	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.559
ATP2A2	STIM1	ENSMODP00000054285	ENSMODP00000046909	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Stromal interaction molecule 1.	0.450
DHRS7C	TRDN	ENSMODP00000044376	ENSMODP00000054571	Dehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein.	0.464
ENSMODP00000045422	ATP2A1	ENSMODP00000045422	ENSMODP00000019420	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.904
ENSMODP00000045422	ATP2A2	ENSMODP00000045422	ENSMODP00000054285	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.904
ENSMODP00000045422	PLN	ENSMODP00000045422	ENSMODP00000029517	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.981
ENSMODP00000045422	SRL	ENSMODP00000045422	ENSMODP00000053021	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.470