(46 nodes) Multicellular organismal response to stress network (Monodelphis domestica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	ENSMODP00000049947	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (496 aa)
	LYPD1	LY6/PLAUR domain containing 1. (140 aa)
	GABRA5	Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (463 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
	DRD4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	HTR2C	G_PROTEIN_RECEP_F1_2 domain-containing protein. (500 aa)
	BCL2	BCL2 apoptosis regulator. (188 aa)
	MAPK8IP2	Mitogen-activated protein kinase 8 interacting protein 2. (991 aa)
	VWA1	Von Willebrand factor A domain containing 1. (495 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1123 aa)
	NMUR2	Neuromedin U receptor 2. (404 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (399 aa)
	F7BA89_MONDO	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (740 aa)
	TACR1	Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (409 aa)
	MECP2	Methyl-CpG binding protein 2. (537 aa)
	GCH1	GTP cyclohydrolase 1. (355 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (390 aa)
	DBH	Dopamine beta-hydroxylase. (614 aa)
	F6VQE9_MONDO	Uncharacterized protein. (435 aa)
	VDAC1	Voltage dependent anion channel 1. (400 aa)
	P2RX2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (473 aa)
	ALS2	Alsin Rho guanine nucleotide exchange factor ALS2. (1801 aa)
	TAC1	Tachykinin precursor 1. (120 aa)
	NTRK1	Tyrosine-protein kinase receptor. (739 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	LPAR5	Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	THBS4	Thrombospondin 4. (955 aa)
	P2RX3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (400 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (235 aa)
	UCN	Urocortin. (130 aa)
	NOS1	Nitric oxide synthase 1. (1464 aa)
	F6WC06_MONDO	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (217 aa)
	DPP4	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (806 aa)
	K7DZ69_MONDO	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (205 aa)
	MORC1	MORC family CW-type zinc finger 1. (958 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (337 aa)
	PIRT	Phosphoinositide interacting regulator of transient receptor potential channels. (176 aa)
	THBS1	Thrombospondin 1. (1197 aa)
	PENK	Uncharacterized protein. (266 aa)
	ENSMODP00000052394	Protein kinase domain-containing protein. (279 aa)
	RELN	Reelin. (3458 aa)
	MTOR	Serine/threonine-protein kinase mTOR. (1040 aa)
	P2RX2-2	Uncharacterized protein. (64 aa)
	ENSMODP00000059959	AGC-kinase C-terminal domain-containing protein. (64 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCYAP1R1	UCN	ENSMODP00000043365	ENSMODP00000028973	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family.	Urocortin.	0.536
BCL2	NR4A2	ENSMODP00000006458	ENSMODP00000005293	BCL2 apoptosis regulator.	Nuclear receptor subfamily 4 group A member 2.	0.447
BCL2	VDAC1	ENSMODP00000006458	ENSMODP00000017701	BCL2 apoptosis regulator.	Voltage dependent anion channel 1.	0.829
DBH	DRD4	ENSMODP00000016277	ENSMODP00000002206	Dopamine beta-hydroxylase.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.422
DBH	TAC1	ENSMODP00000016277	ENSMODP00000020552	Dopamine beta-hydroxylase.	Tachykinin precursor 1.	0.414
DPP4	TAC1	ENSMODP00000038697	ENSMODP00000020552	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	Tachykinin precursor 1.	0.411
DRD4	DBH	ENSMODP00000002206	ENSMODP00000016277	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Dopamine beta-hydroxylase.	0.422
EIF4E	F7BA89_MONDO	ENSMODP00000025914	ENSMODP00000013940	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.639
EIF4E	MTOR	ENSMODP00000025914	ENSMODP00000057648	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	Serine/threonine-protein kinase mTOR.	0.639
ENSMODP00000049947	F7BA89_MONDO	ENSMODP00000049947	ENSMODP00000013940	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.729
ENSMODP00000049947	MTOR	ENSMODP00000049947	ENSMODP00000057648	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Serine/threonine-protein kinase mTOR.	0.729
ENSMODP00000052394	F7BA89_MONDO	ENSMODP00000052394	ENSMODP00000013940	Protein kinase domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.729
ENSMODP00000052394	MTOR	ENSMODP00000052394	ENSMODP00000057648	Protein kinase domain-containing protein.	Serine/threonine-protein kinase mTOR.	0.729
ENSMODP00000059959	F7BA89_MONDO	ENSMODP00000059959	ENSMODP00000013940	AGC-kinase C-terminal domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.729
ENSMODP00000059959	MTOR	ENSMODP00000059959	ENSMODP00000057648	AGC-kinase C-terminal domain-containing protein.	Serine/threonine-protein kinase mTOR.	0.729
F6WC06_MONDO	K7DZ69_MONDO	ENSMODP00000036175	ENSMODP00000038820	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.893
F7BA89_MONDO	EIF4E	ENSMODP00000013940	ENSMODP00000025914	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	0.639
F7BA89_MONDO	ENSMODP00000049947	ENSMODP00000013940	ENSMODP00000049947	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.729
F7BA89_MONDO	ENSMODP00000052394	ENSMODP00000013940	ENSMODP00000052394	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein.	0.729
F7BA89_MONDO	ENSMODP00000059959	ENSMODP00000013940	ENSMODP00000059959	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	AGC-kinase C-terminal domain-containing protein.	0.729