STRINGSTRING
GCN1 GCN1 CDKN1A CDKN1A NPRL2 NPRL2 RRAGB RRAGB SZT2 SZT2 F7BA89_MONDO F7BA89_MONDO SESN2 SESN2 EIF2S1 EIF2S1 DEPDC5 DEPDC5 RNF167 RNF167 FLCN FLCN RNF152 RNF152 EIF2AK4 EIF2AK4 SESN3 SESN3 KPTN KPTN ATF2 ATF2 EIF2AK3 EIF2AK3 ATF4 ATF4 EIF2AK2 EIF2AK2 ITFG2 ITFG2 RRAGD RRAGD MAPK1 MAPK1 MAP3K5 MAP3K5 WDR24 WDR24 NPRL3 NPRL3 MAPK3 MAPK3 F7E823_MONDO F7E823_MONDO MTOR MTOR ATF3 ATF3 WDR59 WDR59 IMPACT IMPACT ENSMODP00000052532 ENSMODP00000052532 ENSMODP00000049497 ENSMODP00000049497 BMT2 BMT2 SEH1L SEH1L SESN1 SESN1 DAPL1 DAPL1 DAP DAP C8H12orf66 C8H12orf66 SH3GLB1 SH3GLB1 F6QBX0_MONDO F6QBX0_MONDO LARS1 LARS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GCN1GCN1 activator of EIF2AK4. (2669 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
RRAGBRas related GTP binding B. (366 aa)
SZT2SZT2 subunit of KICSTOR complex. (2535 aa)
F7BA89_MONDOUncharacterized protein; Belongs to the PI3/PI4-kinase family. (740 aa)
SESN2Sestrin 2. (478 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
DEPDC5DEP domain-containing protein. (1366 aa)
RNF167Ring finger protein 167. (337 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
RNF152Ring finger protein 152. (204 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1663 aa)
SESN3Sestrin 3. (484 aa)
KPTNKaptin, actin binding protein. (451 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1104 aa)
ATF4Activating transcription factor 4. (346 aa)
EIF2AK2Uncharacterized protein. (651 aa)
ITFG2Uncharacterized protein. (439 aa)
RRAGDRas related GTP binding D. (401 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1390 aa)
WDR24WD repeat domain 24. (788 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (579 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
F7E823_MONDOProtein kinase domain-containing protein. (353 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
ATF3BZIP domain-containing protein. (181 aa)
WDR59WD repeat domain 59. (1107 aa)
IMPACTImpact RWD domain protein. (337 aa)
ENSMODP00000052532Uncharacterized protein. (398 aa)
ENSMODP00000049497Uncharacterized protein. (192 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (426 aa)
SESN1Sestrin 1. (514 aa)
DAPL1Death associated protein like 1. (106 aa)
DAPUncharacterized protein. (185 aa)
C8H12orf66Chromosome 12 open reading frame 66. (495 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (402 aa)
F6QBX0_MONDOUncharacterized protein. (98 aa)
LARS1Leucyl-tRNA synthetase. (1024 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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