(62 nodes) Negative regulation of transmembrane transport network (Monodelphis domestica)

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	PID1	Phosphotyrosine interaction domain containing 1. (203 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
	KCNE1	Uncharacterized protein. (126 aa)
	GRP	Uncharacterized protein. (237 aa)
	STK39	Serine/threonine kinase 39. (570 aa)
	THBS1	Thrombospondin 1. (1197 aa)
	OAZ2	Uncharacterized protein. (189 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (465 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (594 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (242 aa)
	FMR1	Fragile X mental retardation 1. (631 aa)
	OSTN	Osteocrin. (142 aa)
	CTTNBP2NL	CTTNBP2 N-terminal like. (607 aa)
	SLC30A1	Uncharacterized protein. (505 aa)
	CLIC2	GST N-terminal domain-containing protein. (244 aa)
	EPO	Erythropoietin. (188 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (1272 aa)
	ARL6IP5	PRA1 family protein. (123 aa)
	SUMO1	Ubiquitin-like domain-containing protein. (162 aa)
	BIN1	Bridging integrator 1. (613 aa)
	COMMD1	Copper metabolism domain containing 1. (242 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
	KEL	Kell metallo-endopeptidase (Kell blood group). (714 aa)
	LOC100013073	Peptidase M60 domain-containing protein. (916 aa)
	DRD4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	GNB5	G protein subunit beta 5. (353 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (663 aa)
	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1545 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (618 aa)
	CRBN	Cereblon. (450 aa)
	OAZ1	Uncharacterized protein. (226 aa)
	REM2	RRAD and GEM like GTPase 2. (348 aa)
	BCL2	BCL2 apoptosis regulator. (188 aa)
	CBARP	Uncharacterized protein. (901 aa)
	FABP5	Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
	KCNE3	Potassium voltage-gated channel subfamily E regulatory subunit 3. (111 aa)
	GEM	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
	ACTN2	Actinin alpha 2. (894 aa)
	NEDD4	NEDD4 E3 ubiquitin protein ligase. (1238 aa)
	GRB10	Growth factor receptor bound protein 10. (596 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (251 aa)
	PEA15	Proliferation and apoptosis adaptor protein 15. (130 aa)
	SESTD1	SEC14 and spectrin domain containing 1. (695 aa)
	SLC43A2	Solute carrier family 43 member 2. (402 aa)
	SRI	Sorcin. (234 aa)
	OSR1	Odd-skipped related transcription factor 1. (265 aa)
	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1570 aa)
	MMP9	Matrix metallopeptidase 9. (709 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	SLC26A5	Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (754 aa)
	GOPC	PDZ domain-containing protein. (459 aa)
	DRD3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (400 aa)
	OAZ3	Uncharacterized protein. (237 aa)
	REM1	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (306 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (997 aa)
	KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4. (169 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	OXSR1	Protein kinase domain-containing protein. (551 aa)
	SLC43A1	Solute carrier family 43 member 1. (532 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL2	PEA15	ENSMODP00000002413	ENSMODP00000012034	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Proliferation and apoptosis adaptor protein 15.	0.667
BCL2	LEP	ENSMODP00000006458	ENSMODP00000044791	BCL2 apoptosis regulator.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.552
BCL2	MMP9	ENSMODP00000006458	ENSMODP00000017178	BCL2 apoptosis regulator.	Matrix metallopeptidase 9.	0.612
BCL2	PPIF	ENSMODP00000006458	ENSMODP00000001343	BCL2 apoptosis regulator.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.678
BCL2	REM1	ENSMODP00000006458	ENSMODP00000024329	BCL2 apoptosis regulator.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.586
BCL2	TNF	ENSMODP00000006458	ENSMODP00000019686	BCL2 apoptosis regulator.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.628
CAV1	CAV3	ENSMODP00000019745	ENSMODP00000049955	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.969
CAV1	NEDD4	ENSMODP00000019745	ENSMODP00000010094	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	NEDD4 E3 ubiquitin protein ligase.	0.412
CAV1	NEDD4L	ENSMODP00000019745	ENSMODP00000055669	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	NEDD4 like E3 ubiquitin protein ligase.	0.408
CAV1	REM1	ENSMODP00000019745	ENSMODP00000024329	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.455
CAV3	CAV1	ENSMODP00000049955	ENSMODP00000019745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.969
CAV3	EPO	ENSMODP00000049955	ENSMODP00000054652	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Erythropoietin.	0.449
CAV3	KCNE2	ENSMODP00000049955	ENSMODP00000037811	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.406
DRD3	DRD4	ENSMODP00000022661	ENSMODP00000002206	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.730
DRD3	GNB5	ENSMODP00000022661	ENSMODP00000002374	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	G protein subunit beta 5.	0.507
DRD4	DRD3	ENSMODP00000002206	ENSMODP00000022661	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.730
DRD4	GNB5	ENSMODP00000002206	ENSMODP00000002374	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G protein subunit beta 5.	0.946
EPO	CAV3	ENSMODP00000054652	ENSMODP00000049955	Erythropoietin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.449
EPO	LEP	ENSMODP00000054652	ENSMODP00000044791	Erythropoietin.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.459
GNB5	DRD3	ENSMODP00000002374	ENSMODP00000022661	G protein subunit beta 5.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.507