(22 nodes) Neurotrophin signaling pathway network (Monodelphis domestica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (285 aa)
	MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1376 aa)
	ZFYVE27	Zinc finger FYVE-type containing 27. (403 aa)
	NTRK2	Tyrosine-protein kinase receptor. (750 aa)
	NTRK3	Tyrosine-protein kinase receptor. (850 aa)
	NTRK1	Tyrosine-protein kinase receptor. (739 aa)
	F7ASC3_MONDO	Uncharacterized protein. (274 aa)
	DDIT4	DNA damage inducible transcript 4. (226 aa)
	SORT1	Sortilin. (693 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (238 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	NTF4	Neurotrophin 4; Belongs to the NGF-beta family. (249 aa)
	KIDINS220	Kinase D interacting substrate 220. (1784 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (523 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (343 aa)
	GFRA1	GDNF family receptor alpha 1. (511 aa)
	ENSMODP00000059044	SH2 domain-containing protein. (79 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1090 aa)
	AKT1S1	Uncharacterized protein. (167 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1703 aa)
	NKPD1	NTPase KAP family P-loop domain containing 1. (520 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	GFRA1	ENSMODP00000046028	ENSMODP00000059399	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	GDNF family receptor alpha 1.	0.602
BDNF	NTF3	ENSMODP00000046028	ENSMODP00000060188	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.941
BDNF	NTF4	ENSMODP00000046028	ENSMODP00000017220	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neurotrophin 4; Belongs to the NGF-beta family.	0.956
BDNF	NTRK1	ENSMODP00000046028	ENSMODP00000020848	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.830
BDNF	NTRK2	ENSMODP00000046028	ENSMODP00000035172	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.993
BDNF	NTRK3	ENSMODP00000046028	ENSMODP00000035165	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.879
BDNF	SORT1	ENSMODP00000046028	ENSMODP00000002515	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Sortilin.	0.855
BDNF	SOS1	ENSMODP00000046028	ENSMODP00000010955	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.483
ENSMODP00000059044	NTRK2	ENSMODP00000059044	ENSMODP00000035172	SH2 domain-containing protein.	Tyrosine-protein kinase receptor.	0.419
ENSMODP00000059044	SOS1	ENSMODP00000059044	ENSMODP00000010955	SH2 domain-containing protein.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.898
F7ASC3_MONDO	NTRK2	ENSMODP00000020528	ENSMODP00000035172	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.419
F7ASC3_MONDO	SOS1	ENSMODP00000020528	ENSMODP00000010955	Uncharacterized protein.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.898
GFRA1	BDNF	ENSMODP00000059399	ENSMODP00000046028	GDNF family receptor alpha 1.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.602
GFRA1	NTRK3	ENSMODP00000059399	ENSMODP00000035165	GDNF family receptor alpha 1.	Tyrosine-protein kinase receptor.	0.447
KIDINS220	MAGI2	ENSMODP00000018321	ENSMODP00000045877	Kinase D interacting substrate 220.	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.768
KIDINS220	NTRK1	ENSMODP00000018321	ENSMODP00000020848	Kinase D interacting substrate 220.	Tyrosine-protein kinase receptor.	0.419
KIDINS220	NTRK2	ENSMODP00000018321	ENSMODP00000035172	Kinase D interacting substrate 220.	Tyrosine-protein kinase receptor.	0.496
KIDINS220	NTRK3	ENSMODP00000018321	ENSMODP00000035165	Kinase D interacting substrate 220.	Tyrosine-protein kinase receptor.	0.468
MAGI2	KIDINS220	ENSMODP00000045877	ENSMODP00000018321	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	Kinase D interacting substrate 220.	0.768
MAGI2	NKPD1	ENSMODP00000045877	ENSMODP00000050783	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	NTPase KAP family P-loop domain containing 1.	0.598