(65 nodes) Positive regulation of T cell proliferation network (Monodelphis domestica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F7BHT6_MONDO	Uncharacterized protein. (807 aa)
	IL23R	Uncharacterized protein. (604 aa)
	IL6	Uncharacterized protein. (220 aa)
	F6V029_MONDO	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (235 aa)
	ANXA1	Annexin. (346 aa)
	IGF1	Insulin like growth factor 1. (225 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (286 aa)
	TYK2	Tyrosine-protein kinase. (1193 aa)
	DHPS	Uncharacterized protein. (377 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (540 aa)
	BMI1	RING-type domain-containing protein. (312 aa)
	SLC7A1	Solute carrier family 7 member 1. (609 aa)
	FOXP3	C2H2-type domain-containing protein. (365 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (830 aa)
	SPTA1	Spectrin alpha, erythrocytic 1. (2409 aa)
	EFNB1	Ephrin B1; Belongs to the ephrin family. (343 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1142 aa)
	SASH3	SAM and SH3 domain containing 3. (390 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
	LOC100022501	ZP domain-containing protein. (435 aa)
	LOC100026858	Ig-like domain-containing protein. (262 aa)
	LOC100011470	Signal transducer and activator of transcription. (839 aa)
	LOC100012174	Signal transducer and activator of transcription. (782 aa)
	AGER	Advanced glycosylation end-product specific receptor. (406 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
	PDCD1LG2	Ig-like domain-containing protein. (295 aa)
	JAK2	Tyrosine-protein kinase. (1130 aa)
	IGFBP2	Insulin like growth factor binding protein 2. (319 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (523 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (695 aa)
	TFRC	Transferrin receptor. (771 aa)
	NCK1	Cytoplasmic protein. (419 aa)
	F7C7H2_MONDO	Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
	IL6ST	Interleukin 6 signal transducer. (923 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
	CD6	SRCR domain-containing protein. (446 aa)
	JAK3	Tyrosine-protein kinase. (1097 aa)
	CD28	CD28 molecule. (221 aa)
	CD86	Uncharacterized protein. (238 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	CCL19	C-C motif chemokine. (96 aa)
	ZP3	ZP domain-containing protein. (415 aa)
	K7E4R7_MONDO	Ig-like domain-containing protein. (132 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (183 aa)
	TMIGD2	Ig-like domain-containing protein. (282 aa)
	ENSMODP00000044418	Uncharacterized protein. (176 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	ENSMODP00000044798	Ig-like domain-containing protein. (302 aa)
	HHLA2	Uncharacterized protein. (405 aa)
	CD274	Uncharacterized protein. (274 aa)
	ENSMODP00000047758	Uncharacterized protein. (361 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (251 aa)
	LOC103102395	Uncharacterized protein. (207 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (142 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (187 aa)
	ENSMODP00000053960	KH type-2 domain-containing protein. (115 aa)
	CARD11	Caspase recruitment domain family member 11. (1176 aa)
	ENSMODP00000054835	Uncharacterized protein. (83 aa)
	SYK	Tyrosine-protein kinase. (588 aa)
	LOC103101367	Uncharacterized protein. (211 aa)
	FADD	Uncharacterized protein. (193 aa)
	CD276	Ig-like domain-containing protein. (201 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	IL15	ENSMODP00000018610	ENSMODP00000042052	Advanced glycosylation end-product specific receptor.	Interleukin; Belongs to the IL-15/IL-21 family.	0.414
AGER	IL1B	ENSMODP00000018610	ENSMODP00000017267	Advanced glycosylation end-product specific receptor.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.458
AGER	JAK2	ENSMODP00000018610	ENSMODP00000019196	Advanced glycosylation end-product specific receptor.	Tyrosine-protein kinase.	0.905
ANXA1	CD86	ENSMODP00000002656	ENSMODP00000036920	Annexin.	Uncharacterized protein.	0.423
ANXA1	IL1B	ENSMODP00000002656	ENSMODP00000017267	Annexin.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.419
CARD11	PRKCQ	ENSMODP00000054644	ENSMODP00000020799	Caspase recruitment domain family member 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.993
CARD11	RIPK2	ENSMODP00000054644	ENSMODP00000009583	Caspase recruitment domain family member 11.	Receptor interacting serine/threonine kinase 2.	0.519
CARD11	SYK	ENSMODP00000054644	ENSMODP00000055066	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.564
CARD11	TRAF6	ENSMODP00000054644	ENSMODP00000024756	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.801
CARD11	ZAP70	ENSMODP00000054644	ENSMODP00000004262	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.487
CCL19	PTPRC	ENSMODP00000038285	ENSMODP00000016029	C-C motif chemokine.	Protein tyrosine phosphatase receptor type C.	0.550
CD274	CD86	ENSMODP00000046291	ENSMODP00000036920	Uncharacterized protein.	Uncharacterized protein.	0.677
CD274	ENSMODP00000044418	ENSMODP00000046291	ENSMODP00000044418	Uncharacterized protein.	Uncharacterized protein.	0.437
CD274	ENSMODP00000044798	ENSMODP00000046291	ENSMODP00000044798	Uncharacterized protein.	Ig-like domain-containing protein.	0.445
CD274	FOXP3	ENSMODP00000046291	ENSMODP00000012328	Uncharacterized protein.	C2H2-type domain-containing protein.	0.543
CD274	IL2	ENSMODP00000046291	ENSMODP00000052096	Uncharacterized protein.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.454
CD274	IL6	ENSMODP00000046291	ENSMODP00000001520	Uncharacterized protein.	Uncharacterized protein.	0.427
CD274	K7E4R7_MONDO	ENSMODP00000046291	ENSMODP00000040769	Uncharacterized protein.	Ig-like domain-containing protein.	0.619
CD274	VTCN1	ENSMODP00000046291	ENSMODP00000053079	Uncharacterized protein.	V-set domain containing T cell activation inhibitor 1.	0.445
CD276	CD40LG	ENSMODP00000060298	ENSMODP00000048298	Ig-like domain-containing protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.611