STRINGSTRING
JUP JUP SMO SMO ZPR1 ZPR1 TPR TPR PRKCD PRKCD HDAC3 HDAC3 RBM22 RBM22 TGFB1 TGFB1 F7FRP8_MONDO F7FRP8_MONDO UBR5 UBR5 GLI3 GLI3 DMAP1 DMAP1 EFCAB7 EFCAB7 FLNA FLNA HCLS1 HCLS1 PSEN1 PSEN1 ENSMODP00000057327 ENSMODP00000057327 BAG3 BAG3 MAVS MAVS IPO5 IPO5 LEP LEP ENSMODP00000059954 ENSMODP00000059954 ECT2 ECT2 PIK3R1 PIK3R1 F6XV26_MONDO F6XV26_MONDO ZC3H12A ZC3H12A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JUPJunction plakoglobin. (743 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
ZPR1Uncharacterized protein. (462 aa)
TPRTranslocated promoter region, nuclear basket protein. (2364 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
RBM22Uncharacterized protein. (420 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
F7FRP8_MONDOUncharacterized protein. (422 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2764 aa)
GLI3GLI family zinc finger 3. (1501 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (462 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
FLNAFilamin A. (2558 aa)
HCLS1SH3 domain-containing protein. (408 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)
ENSMODP00000057327Uncharacterized protein. (181 aa)
BAG3BCL2 associated athanogene 3. (586 aa)
MAVSCARD_2 domain-containing protein. (478 aa)
IPO5Importin 5. (1117 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ENSMODP00000059954Uncharacterized protein. (554 aa)
ECT2Epithelial cell transforming 2. (912 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
F6XV26_MONDOUncharacterized protein. (443 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (655 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: low (12%) [HD]