STRINGSTRING
ACTN2 ACTN2 SCN3B SCN3B GIMAP5 GIMAP5 ATPSCKMT ATPSCKMT CACNB4 CACNB4 AKAP7 AKAP7 ENSMODP00000058116 ENSMODP00000058116 TRH TRH CDK5 CDK5 PSEN1 PSEN1 CXCL11 CXCL11 ENSMODP00000057327 ENSMODP00000057327 COX17 COX17 RELN RELN ENSMODP00000054960 ENSMODP00000054960 TRDN TRDN RAMP3 RAMP3 PINK1 PINK1 APLNR APLNR ATP2B1 ATP2B1 RAB3GAP1 RAB3GAP1 PTGES PTGES SLC12A2 SLC12A2 COA8 COA8 CACNB2 CACNB2 TRPC1 TRPC1 ORAI1 ORAI1 BAX BAX CASK CASK TMEM27 TMEM27 PLA2G6 PLA2G6 ENSMODP00000047599 ENSMODP00000047599 TRPV2 TRPV2 STIM1 STIM1 RYR2 RYR2 ATP1B3 ATP1B3 FHL1 FHL1 ENSMODP00000045584 ENSMODP00000045584 WNK2 WNK2 CACNG4 CACNG4 FLNA FLNA WNK1 WNK1 SHANK3 SHANK3 PIRT PIRT ADCYAP1R1 ADCYAP1R1 VAMP8 VAMP8 P2RX5 P2RX5 VMP1 VMP1 LOC103098366 LOC103098366 ITGB1 ITGB1 CXCL9 CXCL9 LOC100017283 LOC100017283 F6XW95_MONDO F6XW95_MONDO KCNE1 KCNE1 F7AQZ1_MONDO F7AQZ1_MONDO F7BG00_MONDO F7BG00_MONDO CACNG2 CACNG2 P2RY12 P2RY12 CNTD1 CNTD1 CCR3 CCR3 P2RY6 P2RY6 JAK3 JAK3 FXYD1 FXYD1 AMIGO1 AMIGO1 UCN UCN AMIGO3 AMIGO3 GJC2 GJC2 IFNGR2 IFNGR2 WNK3 WNK3 PKD2 PKD2 P2RX1 P2RX1 MS4A1 MS4A1 LRRC55 LRRC55 F2 F2 HOMER1 HOMER1 CEMIP CEMIP PDZK1 PDZK1 SNX4 SNX4 CRACR2A CRACR2A AKAP6 AKAP6 ACE2 ACE2 STC1 STC1 PDPK1 PDPK1 CEBPB CEBPB GABBR1 GABBR1 CAV1 CAV1 CFTR CFTR ATP2A1 ATP2A1 TESC TESC PLCG2 PLCG2 WNK4 WNK4 F2RL3 F2RL3 TNFSF11 TNFSF11 SLC9A1 SLC9A1 DRD2 DRD2 NDUFA4 NDUFA4 BAK1 BAK1 FFAR1 FFAR1 F2R F2R SCN4B SCN4B CX3CL1 CX3CL1 SCN5A SCN5A THY1 THY1 CNTN1 CNTN1 STAC2 STAC2 MLLT6 MLLT6 LRRC38 LRRC38 P2RX4 P2RX4 LGALS3 LGALS3 P2RX7 P2RX7 CCR1 CCR1 EDN1 EDN1 SRI SRI CACNB3 CACNB3 PLA2G3 PLA2G3 PDGFB PDGFB ATF4 ATF4 G6PD G6PD ABCB11 ABCB11 KIF5B KIF5B ATP1B2 ATP1B2 ABCC8 ABCC8 RNF207 RNF207 VAMP7 VAMP7 NKX2-5 NKX2-5 SLC6A1 SLC6A1 PLA2R1 PLA2R1 TNFRSF11A TNFRSF11A PLA2G10 PLA2G10 HTT HTT WFS1 WFS1 AVPR1B AVPR1B DRD4 DRD4 LRRC52 LRRC52 R3HDM1 R3HDM1 EDNRA EDNRA PLCG1 PLCG1 TRPC6 TRPC6 SYT4 SYT4 CHP1 CHP1 STIM2 STIM2 NPSR1 NPSR1 ARC ARC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTN2Actinin alpha 2. (894 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (280 aa)
GIMAP5AIG1-type G domain-containing protein. (332 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (231 aa)
CACNB4SH3 domain-containing protein. (520 aa)
AKAP7Uncharacterized protein. (545 aa)
ENSMODP00000058116G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (232 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)
CXCL11C-X-C motif chemokine ligand 11. (87 aa)
ENSMODP00000057327Uncharacterized protein. (181 aa)
COX17Cytochrome c oxidase copper chaperone COX17. (66 aa)
RELNReelin. (3458 aa)
ENSMODP00000054960Uncharacterized protein. (418 aa)
TRDNUncharacterized protein. (275 aa)
RAMP3Receptor activity modifying protein 3. (159 aa)
PINK1Protein kinase domain-containing protein. (573 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (949 aa)
PTGESUncharacterized protein. (235 aa)
SLC12A2Solute carrier family 12 member 2. (1104 aa)
COA8Uncharacterized protein. (211 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (612 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (749 aa)
ORAI1Uncharacterized protein. (314 aa)
BAXUncharacterized protein. (296 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
TMEM27Collectrin domain-containing protein. (253 aa)
PLA2G6Phospholipase A2 group VI. (818 aa)
ENSMODP00000047599Uncharacterized protein. (59 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (777 aa)
STIM1Stromal interaction molecule 1. (776 aa)
RYR2Ryanodine receptor 2. (4900 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (277 aa)
FHL1Four and a half LIM domains 1. (391 aa)
ENSMODP00000045584G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
WNK2WNK lysine deficient protein kinase 2. (2370 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (357 aa)
FLNAFilamin A. (2558 aa)
WNK1WNK lysine deficient protein kinase 1. (2867 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1695 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (176 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (337 aa)
VAMP8Vesicle associated membrane protein 8. (130 aa)
P2RX5Uncharacterized protein. (202 aa)
VMP1Uncharacterized protein. (406 aa)
LOC103098366AKAP7_NLS domain-containing protein. (991 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (802 aa)
CXCL9C-X-C motif chemokine. (123 aa)
LOC100017283C-C motif chemokine. (91 aa)
F6XW95_MONDOP2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (567 aa)
KCNE1Uncharacterized protein. (126 aa)
F7AQZ1_MONDOSCY domain-containing protein. (144 aa)
F7BG00_MONDOUncharacterized protein. (399 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (302 aa)
P2RY12Purinergic receptor P2Y12. (342 aa)
CNTD1Cyclin N-terminal domain containing 1. (332 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (356 aa)
P2RY6Pyrimidinergic receptor P2Y6. (402 aa)
JAK3Tyrosine-protein kinase. (1097 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (253 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
UCNUrocortin. (130 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (499 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (405 aa)
IFNGR2Uncharacterized protein. (344 aa)
WNK3Protein kinase domain-containing protein. (626 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (997 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (585 aa)
MS4A1Membrane spanning 4-domains A1. (287 aa)
LRRC55Leucine rich repeat containing 55. (312 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
HOMER1Homer scaffold protein 1. (410 aa)
CEMIPCell migration inducing hyaluronidase 1. (1366 aa)
PDZK1PDZ domain containing 1. (510 aa)
SNX4Sorting nexin 4. (453 aa)
CRACR2ACalcium release activated channel regulator 2A. (709 aa)
AKAP6A-kinase anchoring protein 6. (2333 aa)
ACE2Angiotensin-converting enzyme. (806 aa)
STC1Stanniocalcin 1. (247 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (455 aa)
CEBPBCCAAT enhancer binding protein beta. (364 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (579 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (948 aa)
TESCTescalcin. (213 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
WNK4WNK lysine deficient protein kinase 4. (1270 aa)
F2RL3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (389 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (392 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (415 aa)
NDUFA4NDUFA4 mitochondrial complex associated. (82 aa)
BAK1BCL2 antagonist/killer 1. (204 aa)
FFAR1Free fatty acid receptor 1. (299 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (230 aa)
CX3CL1SCY domain-containing protein. (409 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1839 aa)
THY1Thy-1 cell surface antigen. (162 aa)
CNTN1Contactin 1. (1007 aa)
STAC2SH3 and cysteine rich domain 2. (410 aa)
MLLT6MLLT6, PHD finger containing. (1017 aa)
LRRC38Leucine rich repeat containing 38. (299 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (390 aa)
LGALS3Galectin. (281 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
EDN1Endothelin 1. (214 aa)
SRISorcin. (234 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (482 aa)
PLA2G3Uncharacterized protein. (688 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
ATF4Activating transcription factor 4. (346 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (616 aa)
ABCB11ATP binding cassette subfamily B member 11. (1322 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (966 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ABCC8ATP binding cassette subfamily C member 8. (1580 aa)
RNF207Ring finger protein 207. (703 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (211 aa)
NKX2-5NK2 homeobox 5. (319 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (600 aa)
PLA2R1Phospholipase A2 receptor 1. (1405 aa)
TNFRSF11ATNFR-Cys domain-containing protein. (670 aa)
PLA2G10Phospholipase A(2). (147 aa)
HTTHuntingtin. (2899 aa)
WFS1Wolframin ER transmembrane glycoprotein. (878 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
DRD4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
LRRC52Uncharacterized protein. (271 aa)
R3HDM1R3H domain containing 1. (1128 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (903 aa)
SYT4Synaptotagmin 4. (426 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
STIM2Stromal interaction molecule 2. (771 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
ARCActivity regulated cytoskeleton associated protein. (400 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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