STRINGSTRING
IRAK3 IRAK3 FLT1 FLT1 AGT AGT MAP2K5 MAP2K5 PDGFB PDGFB HIPK3 HIPK3 TRIB2 TRIB2 EDN1 EDN1 PRKCD PRKCD HTR2B HTR2B DTNBP1 DTNBP1 TGFA TGFA IRAK1 IRAK1 P2RX7 P2RX7 CDK5RAP3 CDK5RAP3 PTPRC PTPRC BMP4 BMP4 SORL1 SORL1 NOD2 NOD2 ADIPOQ ADIPOQ FGD2 FGD2 IL1B IL1B IL34 IL34 TNFSF11 TNFSF11 AGER AGER DUSP10 DUSP10 F6WK84_MONDO F6WK84_MONDO TNFRSF11A TNFRSF11A TSG101 TSG101 TENM1 TENM1 TNXB TNXB MAP2K7 MAP2K7 NEK10 NEK10 INSR INSR TNF TNF CAV1 CAV1 PTK2B PTK2B FZD5 FZD5 PTPN1 PTPN1 PIK3CG PIK3CG DKK1 DKK1 SASH1 SASH1 GBA GBA MAP3K5 MAP3K5 PTPN6 PTPN6 DUSP16 DUSP16 LRRK2 LRRK2 SMPD1 SMPD1 FGF2 FGF2 VEGFA VEGFA ROR2 ROR2 TRAF6 TRAF6 TRIB3 TRIB3 THBS1 THBS1 MAP3K4 MAP3K4 TPD52L1 TPD52L1 INPP5K INPP5K MAP3K11 MAP3K11 ENSMODP00000042313 ENSMODP00000042313 MAP3K7 MAP3K7 SH2B3 SH2B3 FGF1 FGF1 ENSMODP00000049462 ENSMODP00000049462 RASGRP1 RASGRP1 CAV3 CAV3 MAPK8IP1 MAPK8IP1 ENSMODP00000052422 ENSMODP00000052422 SPRY1 SPRY1 DAB2IP DAB2IP EPGN EPGN PIK3CB PIK3CB ENSMODP00000053548 ENSMODP00000053548 DUSP19 DUSP19 ENSMODP00000053960 ENSMODP00000053960 ENSMODP00000054835 ENSMODP00000054835 SYK SYK F6TN87_MONDO F6TN87_MONDO SPRY2 SPRY2 SFRP2 SFRP2 F6YRI3_MONDO F6YRI3_MONDO ENSMODP00000056005 ENSMODP00000056005 ENSMODP00000056713 ENSMODP00000056713 FGF18 FGF18 NF1 NF1 LYN LYN APOE APOE ARHGEF5 ARHGEF5 PSEN1 PSEN1 NTF3 NTF3 KSR1 KSR1 UCHL1 UCHL1 PAQR3 PAQR3 LOC100017469 LOC100017469 F6TPY2_MONDO F6TPY2_MONDO SPRY4 SPRY4 EZH2 EZH2 F7GFS5_MONDO F7GFS5_MONDO PDCD10 PDCD10 AKAP13 AKAP13 NTRK3 NTRK3 ERN2 ERN2 KIT KIT SPRY3 SPRY3 CCL19 CCL19 F6XW95_MONDO F6XW95_MONDO LAX1 LAX1 K7E0A4_MONDO K7E0A4_MONDO CBLC CBLC LOC103093164 LOC103093164 K7E532_MONDO K7E532_MONDO ENSMODP00000041408 ENSMODP00000041408 AXIN1 AXIN1 AJUBA AJUBA LIME1 LIME1 PDGFC PDGFC TRIB1 TRIB1 DRD4 DRD4 HMGCR HMGCR F7CYW1_MONDO F7CYW1_MONDO MAP3K13 MAP3K13 NOX4 NOX4 HGS HGS ERP29 ERP29 DVL3 DVL3 BMP2 BMP2 FZD4 FZD4 DVL2 DVL2 FZD8 FZD8 RPS3 RPS3 PIK3R5 PIK3R5 TGFB1 TGFB1 SOS1 SOS1 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRAK3Interleukin 1 receptor associated kinase 3. (591 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
AGTAngiotensinogen; Belongs to the serpin family. (469 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
HIPK3Homeodomain interacting protein kinase 3. (1247 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
EDN1Endothelin 1. (214 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
HTR2B5-hydroxytryptamine receptor 2B; Belongs to the G-protein coupled receptor 1 family. (473 aa)
DTNBP1Dystrobrevin binding protein 1. (346 aa)
TGFATransforming growth factor alpha. (159 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (685 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (506 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1142 aa)
BMP4Bone morphogenetic protein 4. (410 aa)
SORL1Sortilin related receptor 1. (2218 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1012 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (256 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (618 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
IL34Uncharacterized protein. (279 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
AGERAdvanced glycosylation end-product specific receptor. (406 aa)
DUSP10Dual specificity phosphatase 10. (482 aa)
F6WK84_MONDOUncharacterized protein. (294 aa)
TNFRSF11ATNFR-Cys domain-containing protein. (670 aa)
TSG101Uncharacterized protein. (391 aa)
TENM1Teneurin transmembrane protein 1. (2741 aa)
TNXBTenascin XB. (536 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (546 aa)
NEK10NIMA related kinase 10. (1091 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (391 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1099 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (289 aa)
SASH1Uncharacterized protein. (648 aa)
GBAGlucosylceramidase. (535 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1390 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
DUSP16Dual specificity phosphatase 16. (660 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
TRIB3Protein kinase domain-containing protein. (146 aa)
THBS1Thrombospondin 1. (1197 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1621 aa)
TPD52L1TPD52 like 1. (214 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (465 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (859 aa)
ENSMODP00000042313Uncharacterized protein. (84 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
SH2B3SH2 domain-containing protein. (458 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
ENSMODP00000049462Uncharacterized protein. (802 aa)
RASGRP1RAS guanyl releasing protein 1. (861 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (242 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (646 aa)
ENSMODP00000052422UEV domain-containing protein. (123 aa)
SPRY1Uncharacterized protein. (105 aa)
DAB2IPDAB2 interacting protein. (1180 aa)
EPGNEGF-like domain-containing protein. (152 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
ENSMODP00000053548Aida_C2 domain-containing protein. (130 aa)
DUSP19Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (202 aa)
ENSMODP00000053960KH type-2 domain-containing protein. (115 aa)
ENSMODP00000054835Uncharacterized protein. (83 aa)
SYKTyrosine-protein kinase. (588 aa)
F6TN87_MONDOUncharacterized protein. (519 aa)
SPRY2Sprouty RTK signaling antagonist 2. (317 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
F6YRI3_MONDOUncharacterized protein. (647 aa)
ENSMODP00000056005Sema domain-containing protein. (996 aa)
ENSMODP00000056713Aida_C2 domain-containing protein. (130 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
NF1Neurofibromin 1. (2781 aa)
LYNTyrosine-protein kinase. (516 aa)
APOEUncharacterized protein. (299 aa)
ARHGEF5ARHGEF5_35 domain-containing protein. (1125 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (343 aa)
KSR1Kinase suppressor of ras 1. (918 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C- terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity); Belongs to the peptidase C12 family. (223 aa)
PAQR3Progestin and adipoQ receptor family member 3. (311 aa)
LOC100017469Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1570 aa)
F6TPY2_MONDOUncharacterized protein. (272 aa)
SPRY4Sprouty RTK signaling antagonist 4. (300 aa)
EZH2Uncharacterized protein. (665 aa)
F7GFS5_MONDOUncharacterized protein. (1113 aa)
PDCD10Uncharacterized protein. (149 aa)
AKAP13Uncharacterized protein. (1424 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (880 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
SPRY3Uncharacterized protein. (109 aa)
CCL19C-C motif chemokine. (96 aa)
F6XW95_MONDOP2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (567 aa)
LAX1Uncharacterized protein. (410 aa)
K7E0A4_MONDOUncharacterized protein. (667 aa)
CBLCCbl-PTB domain-containing protein. (416 aa)
LOC103093164Ig-like domain-containing protein. (298 aa)
K7E532_MONDOUncharacterized protein. (151 aa)
ENSMODP00000041408Uncharacterized protein. (134 aa)
AXIN1Axin 1. (875 aa)
AJUBAAjuba LIM protein. (537 aa)
LIME1Uncharacterized protein. (249 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
TRIB1Tribbles pseudokinase 1. (369 aa)
DRD4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (907 aa)
F7CYW1_MONDOUncharacterized protein. (544 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase. (964 aa)
NOX4NADPH oxidase 4. (578 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (779 aa)
ERP29Endoplasmic reticulum protein 29. (265 aa)
DVL3Dishevelled segment polarity protein 3. (635 aa)
BMP2Bone morphogenetic protein 2. (436 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (710 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (873 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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