(82 nodes) Positive regulation of MAP kinase activity network (Monodelphis domestica)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	PTPRC	Protein tyrosine phosphatase receptor type C. (1142 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (685 aa)
	TGFA	Transforming growth factor alpha. (159 aa)
	HTR2B	5-hydroxytryptamine receptor 2B; Belongs to the G-protein coupled receptor 1 family. (473 aa)
	EDN1	Endothelin 1. (214 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
	EGFR	Receptor protein-tyrosine kinase. (1213 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (873 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (710 aa)
	DVL2	Dishevelled segment polarity protein 2. (731 aa)
	TNFRSF11A	TNFR-Cys domain-containing protein. (670 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
	DVL3	Dishevelled segment polarity protein 3. (635 aa)
	ERP29	Endoplasmic reticulum protein 29. (265 aa)
	NOX4	NADPH oxidase 4. (578 aa)
	MAP3K13	Mitogen-activated protein kinase kinase kinase. (964 aa)
	F7CYW1_MONDO	Uncharacterized protein. (544 aa)
	DRD4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	PDGFC	Platelet derived growth factor C. (345 aa)
	F6TN87_MONDO	Uncharacterized protein. (519 aa)
	F6YRI3_MONDO	Uncharacterized protein. (647 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (343 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)
	ARHGEF5	ARHGEF5_35 domain-containing protein. (1125 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	ENSMODP00000056005	Sema domain-containing protein. (996 aa)
	SYK	Tyrosine-protein kinase. (588 aa)
	ENSMODP00000054835	Uncharacterized protein. (83 aa)
	ENSMODP00000053960	KH type-2 domain-containing protein. (115 aa)
	DUSP19	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (202 aa)
	EPGN	EGF-like domain-containing protein. (152 aa)
	DAB2IP	DAB2 interacting protein. (1180 aa)
	RASGRP1	RAS guanyl releasing protein 1. (861 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
	TPD52L1	TPD52 like 1. (214 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1621 aa)
	THBS1	Thrombospondin 1. (1197 aa)
	MAP3K11	Mitogen-activated protein kinase kinase kinase. (859 aa)
	ENSMODP00000042313	Uncharacterized protein. (84 aa)
	AXIN1	Axin 1. (875 aa)
	AJUBA	Ajuba LIM protein. (537 aa)
	ENSMODP00000041408	Uncharacterized protein. (134 aa)
	K7E0A4_MONDO	Uncharacterized protein. (667 aa)
	F6XW95_MONDO	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (567 aa)
	CCL19	C-C motif chemokine. (96 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
	ERN2	Endoplasmic reticulum to nucleus signaling 2. (880 aa)
	NTRK3	Tyrosine-protein kinase receptor. (850 aa)
	AKAP13	Uncharacterized protein. (1424 aa)
	PDCD10	Uncharacterized protein. (149 aa)
	EZH2	Uncharacterized protein. (665 aa)
	F6TPY2_MONDO	Uncharacterized protein. (272 aa)
	LOC100017469	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1570 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1390 aa)
	SASH1	Uncharacterized protein. (648 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (289 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1099 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (391 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
	INSR	Tyrosine-protein kinase receptor. (1378 aa)
	NEK10	NIMA related kinase 10. (1091 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (546 aa)
	TENM1	Teneurin transmembrane protein 1. (2741 aa)
	AGER	Advanced glycosylation end-product specific receptor. (406 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	IL34	Uncharacterized protein. (279 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
	FGD2	FYVE, RhoGEF and PH domain containing 2. (618 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1012 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	IL1B	ENSMODP00000018610	ENSMODP00000017267	Advanced glycosylation end-product specific receptor.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.458
AGER	NOX4	ENSMODP00000018610	ENSMODP00000003331	Advanced glycosylation end-product specific receptor.	NADPH oxidase 4.	0.907
AGER	TNF	ENSMODP00000018610	ENSMODP00000019686	Advanced glycosylation end-product specific receptor.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.442
AKAP13	ENSMODP00000056005	ENSMODP00000035153	ENSMODP00000056005	Uncharacterized protein.	Sema domain-containing protein.	0.497
AXIN1	DKK1	ENSMODP00000041842	ENSMODP00000020512	Axin 1.	Dickkopf WNT signaling pathway inhibitor 1.	0.452
AXIN1	DVL2	ENSMODP00000041842	ENSMODP00000008135	Axin 1.	Dishevelled segment polarity protein 2.	0.982
AXIN1	DVL3	ENSMODP00000041842	ENSMODP00000003932	Axin 1.	Dishevelled segment polarity protein 3.	0.982
AXIN1	FZD4	ENSMODP00000041842	ENSMODP00000005048	Axin 1.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.519
AXIN1	FZD5	ENSMODP00000041842	ENSMODP00000019903	Axin 1.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.410
AXIN1	FZD8	ENSMODP00000041842	ENSMODP00000008351	Axin 1.	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.410
CCL19	PTPRC	ENSMODP00000038285	ENSMODP00000016029	C-C motif chemokine.	Protein tyrosine phosphatase receptor type C.	0.550
DAB2IP	EGFR	ENSMODP00000053347	ENSMODP00000011264	DAB2 interacting protein.	Receptor protein-tyrosine kinase.	0.419
DAB2IP	MAP3K5	ENSMODP00000053347	ENSMODP00000021762	DAB2 interacting protein.	Mitogen-activated protein kinase kinase kinase 5.	0.970
DKK1	AXIN1	ENSMODP00000020512	ENSMODP00000041842	Dickkopf WNT signaling pathway inhibitor 1.	Axin 1.	0.452
DKK1	IL1B	ENSMODP00000020512	ENSMODP00000017267	Dickkopf WNT signaling pathway inhibitor 1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.410
DKK1	TNFSF11	ENSMODP00000020512	ENSMODP00000018584	Dickkopf WNT signaling pathway inhibitor 1.	Tumor necrosis factor ligand superfamily member.	0.523
DUSP19	MAP2K7	ENSMODP00000053744	ENSMODP00000018708	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase kinase 7.	0.629
DVL2	AXIN1	ENSMODP00000008135	ENSMODP00000041842	Dishevelled segment polarity protein 2.	Axin 1.	0.982
DVL2	DVL3	ENSMODP00000008135	ENSMODP00000003932	Dishevelled segment polarity protein 2.	Dishevelled segment polarity protein 3.	0.901
DVL2	FZD4	ENSMODP00000008135	ENSMODP00000005048	Dishevelled segment polarity protein 2.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.947