(42 nodes) Negative regulation of MAP kinase activity network (Monodelphis domestica)

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Your Input:
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (317 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (907 aa)
	BMP2	Bone morphogenetic protein 2. (436 aa)
	DUSP10	Dual specificity phosphatase 10. (482 aa)
	F6WK84_MONDO	Uncharacterized protein. (294 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (591 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (469 aa)
	HIPK3	Homeodomain interacting protein kinase 3. (1247 aa)
	CDK5RAP3	CDK5 regulatory subunit associated protein 3. (506 aa)
	BMP4	Bone morphogenetic protein 4. (410 aa)
	SORL1	Sortilin related receptor 1. (2218 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (256 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (391 aa)
	GBA	Glucosylceramidase. (535 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	DUSP16	Dual specificity phosphatase 16. (660 aa)
	SMPD1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
	UCHL1	Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C- terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity); Belongs to the peptidase C12 family. (223 aa)
	PAQR3	Progestin and adipoQ receptor family member 3. (311 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (300 aa)
	F7GFS5_MONDO	Uncharacterized protein. (1113 aa)
	SPRY3	Uncharacterized protein. (109 aa)
	LAX1	Uncharacterized protein. (410 aa)
	CBLC	Cbl-PTB domain-containing protein. (416 aa)
	LOC103093164	Ig-like domain-containing protein. (298 aa)
	K7E532_MONDO	Uncharacterized protein. (151 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (465 aa)
	SH2B3	SH2 domain-containing protein. (458 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (242 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (646 aa)
	SPRY1	Uncharacterized protein. (105 aa)
	DAB2IP	DAB2 interacting protein. (1180 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
	ENSMODP00000053548	Aida_C2 domain-containing protein. (130 aa)
	DUSP19	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (202 aa)
	ENSMODP00000056713	Aida_C2 domain-containing protein. (130 aa)
	NF1	Neurofibromin 1. (2781 aa)
	LYN	Tyrosine-protein kinase. (516 aa)
	APOE	Uncharacterized protein. (299 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APOE	ENSMODP00000016761	ENSMODP00000057511	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.406
ADIPOQ	PAQR3	ENSMODP00000016761	ENSMODP00000026023	Adiponectin, C1Q and collagen domain containing.	Progestin and adipoQ receptor family member 3.	0.629
AGT	APOE	ENSMODP00000011483	ENSMODP00000057511	Angiotensinogen; Belongs to the serpin family.	Uncharacterized protein.	0.484
APOE	ADIPOQ	ENSMODP00000057511	ENSMODP00000016761	Uncharacterized protein.	Adiponectin, C1Q and collagen domain containing.	0.406
APOE	AGT	ENSMODP00000057511	ENSMODP00000011483	Uncharacterized protein.	Angiotensinogen; Belongs to the serpin family.	0.484
APOE	CAV1	ENSMODP00000057511	ENSMODP00000019745	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.418
APOE	HMGCR	ENSMODP00000057511	ENSMODP00000002510	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.449
APOE	SORL1	ENSMODP00000057511	ENSMODP00000016287	Uncharacterized protein.	Sortilin related receptor 1.	0.867
BMP2	BMP4	ENSMODP00000004813	ENSMODP00000016205	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.901
BMP4	BMP2	ENSMODP00000016205	ENSMODP00000004813	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.901
CAV1	APOE	ENSMODP00000019745	ENSMODP00000057511	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.418
CAV1	CAV3	ENSMODP00000019745	ENSMODP00000049955	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.969
CAV1	LYN	ENSMODP00000019745	ENSMODP00000057480	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.471
CAV3	CAV1	ENSMODP00000049955	ENSMODP00000019745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.969
CBLC	LYN	ENSMODP00000039257	ENSMODP00000057480	Cbl-PTB domain-containing protein.	Tyrosine-protein kinase.	0.497
CBLC	PIK3CB	ENSMODP00000039257	ENSMODP00000053456	Cbl-PTB domain-containing protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.417
CBLC	SH2B3	ENSMODP00000039257	ENSMODP00000048751	Cbl-PTB domain-containing protein.	SH2 domain-containing protein.	0.427
CBLC	SPRY1	ENSMODP00000039257	ENSMODP00000052725	Cbl-PTB domain-containing protein.	Uncharacterized protein.	0.571
CBLC	SPRY2	ENSMODP00000039257	ENSMODP00000001945	Cbl-PTB domain-containing protein.	Sprouty RTK signaling antagonist 2.	0.708
CBLC	SPRY3	ENSMODP00000039257	ENSMODP00000038015	Cbl-PTB domain-containing protein.	Uncharacterized protein.	0.708