STRINGSTRING
ADCY2 ADCY2 BACE1 BACE1 F2R F2R PLLP PLLP GPC1 GPC1 SCN5A SCN5A LIPE LIPE CBL CBL THY1 THY1 CNTN1 CNTN1 PTPRC PTPRC TGFBR1 TGFBR1 SKAP1 SKAP1 SGCA SGCA CAVIN2 CAVIN2 P2RX7 P2RX7 BTK BTK HTR2A HTR2A CTNNB1 CTNNB1 EFNB1 EFNB1 TFPI TFPI HK1 HK1 ARID3C ARID3C SULF1 SULF1 CAVIN4 CAVIN4 IGF1R IGF1R PSEN1 PSEN1 PARK7 PARK7 LYN LYN SDCBP SDCBP NEU3 NEU3 ENSMODP00000054960 ENSMODP00000054960 ENSMODP00000054835 ENSMODP00000054835 CARD11 CARD11 RANGRF RANGRF ERLIN2 ERLIN2 HDAC6 HDAC6 CXADR CXADR BCL10 BCL10 BSG BSG UNC5A UNC5A ASAH2 ASAH2 CAV3 CAV3 DLL1 DLL1 ORAI1 ORAI1 TLR10 TLR10 DAG1 DAG1 EZR EZR RGS19 RGS19 LAMTOR5 LAMTOR5 ENSMODP00000047599 ENSMODP00000047599 GLIPR1L1 GLIPR1L1 STIM1 STIM1 ADD2 ADD2 SORBS1 SORBS1 INPP5D INPP5D CLIP3 CLIP3 ADCY1 ADCY1 PSEN2 PSEN2 PRNP PRNP ENSMODP00000045150 ENSMODP00000045150 CAV2 CAV2 PLPP1 PLPP1 MYO1C MYO1C MAG MAG SCARB1 SCARB1 NFAM1 NFAM1 CDH15 CDH15 LAMTOR2 LAMTOR2 ADCYAP1R1 ADCYAP1R1 APP APP MAL2 MAL2 EMP2 EMP2 HAS2 HAS2 ENSMODP00000042431 ENSMODP00000042431 EFNA5 EFNA5 ENSMODP00000041483 ENSMODP00000041483 LOC103098388 LOC103098388 ITGB1 ITGB1 PODXL PODXL CBLC CBLC PLVAP PLVAP DPP4 DPP4 F6XW95_MONDO F6XW95_MONDO KCNE1 KCNE1 TLR2 TLR2 CD4 CD4 NOS3 NOS3 FXYD1 FXYD1 CD14 CD14 CORO1C CORO1C NOS1 NOS1 STAT6 STAT6 NPC1 NPC1 GHSR GHSR AQP1 AQP1 ABCG2 ABCG2 LAMTOR3 LAMTOR3 KDR KDR TLR6 TLR6 P2RX1 P2RX1 MS4A1 MS4A1 P2RX3 P2RX3 LRP4 LRP4 SLC1A2 SLC1A2 STOM STOM IL6ST IL6ST HCK HCK ITGA1 ITGA1 MYO1A MYO1A FLOT2 FLOT2 HPSE HPSE DLC1 DLC1 CAVIN3 CAVIN3 TPP1 TPP1 LRRK2 LRRK2 LRP6 LRP6 TNFRSF1A TNFRSF1A BVES BVES LDHB LDHB MAPK1 MAPK1 PPT1 PPT1 AKAP6 AKAP6 LCK LCK SLC2A1 SLC2A1 CD36 CD36 ADRA1A ADRA1A F6YPZ7_MONDO F6YPZ7_MONDO PTGIS PTGIS GABBR1 GABBR1 PTK2B PTK2B PIKFYVE PIKFYVE FLOT1 FLOT1 CAV1 CAV1 TNF TNF MAPK3 MAPK3 CLN3 CLN3 JAK2 JAK2 TGFBR2 TGFBR2 INSR INSR CDH13 CDH13 CAVIN1 CAVIN1 ADAM17 ADAM17 F7E823_MONDO F7E823_MONDO RFTN1 RFTN1 SLC9A1 SLC9A1 ARC ARC LRP8 LRP8 RHOQ RHOQ ATP2B4 ATP2B4 RET RET SLC6A3 SLC6A3 ADCY8 ADCY8 CBLB CBLB PTCH1 PTCH1 LYPD6 LYPD6 PLPP3 PLPP3 LOC100028162 LOC100028162 TEK TEK FAIM2 FAIM2 LAMTOR4 LAMTOR4 MLC1 MLC1 TNR TNR BAALC BAALC ARID3A ARID3A NPHS2 NPHS2 PLPP2 PLPP2 PAG1 PAG1 SLC2A4 SLC2A4 SERPINH1 SERPINH1 LCP2 LCP2 KCNE3 KCNE3 MALL MALL STOML2 STOML2 SYNJ2 SYNJ2 ADRA1B ADRA1B TRPM8 TRPM8 LAMTOR1 LAMTOR1 RIPK1 RIPK1 UNC5B UNC5B EGFR EGFR CLN6 CLN6 AKAP5 AKAP5 KIF18A KIF18A SLC6A4 SLC6A4 TRPC4 TRPC4 CRK CRK STOML3 STOML3 IKBKB IKBKB ADTRP ADTRP RTN4RL1 RTN4RL1 ADGRG1 ADGRG1 VDAC1 VDAC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (500 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
PLLPPlasmolipin. (186 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (550 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1839 aa)
LIPEHSL_N domain-containing protein. (664 aa)
CBLCbl proto-oncogene. (837 aa)
THY1Thy-1 cell surface antigen. (162 aa)
CNTN1Contactin 1. (1007 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1142 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
SKAP1Src kinase associated phosphoprotein 1. (360 aa)
SGCASarcoglycan alpha. (372 aa)
CAVIN2Caveolae associated protein 2. (428 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
BTKTyrosine-protein kinase. (655 aa)
HTR2A5-hydroxytryptamine receptor 2A. (469 aa)
CTNNB1Catenin beta 1. (781 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (343 aa)
TFPITissue factor pathway inhibitor. (302 aa)
HK1Hexokinase 1. (922 aa)
ARID3CAT-rich interaction domain 3C. (408 aa)
SULF1Sulfatase 1. (1125 aa)
CAVIN4Uncharacterized protein. (375 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)
PARK7DJ-1_PfpI domain-containing protein. (189 aa)
LYNTyrosine-protein kinase. (516 aa)
SDCBPSyndecan binding protein. (311 aa)
NEU3Neuraminidase 3. (428 aa)
ENSMODP00000054960Uncharacterized protein. (418 aa)
ENSMODP00000054835Uncharacterized protein. (83 aa)
CARD11Caspase recruitment domain family member 11. (1176 aa)
RANGRFRAN guanine nucleotide release factor. (228 aa)
ERLIN2Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. (515 aa)
HDAC6Histone deacetylase 6. (1106 aa)
CXADRIg-like domain-containing protein. (279 aa)
BCL10CARD domain-containing protein. (245 aa)
BSGUncharacterized protein. (391 aa)
UNC5AUnc-5 netrin receptor A. (864 aa)
ASAH2Neutral ceramidase. (392 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (242 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (734 aa)
ORAI1Uncharacterized protein. (314 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (746 aa)
DAG1Dystroglycan 1. (896 aa)
EZREzrin. (587 aa)
RGS19RGS domain-containing protein. (216 aa)
LAMTOR5Uncharacterized protein. (93 aa)
ENSMODP00000047599Uncharacterized protein. (59 aa)
GLIPR1L1SCP domain-containing protein; Belongs to the CRISP family. (290 aa)
STIM1Stromal interaction molecule 1. (776 aa)
ADD2Adducin 2. (735 aa)
SORBS1Sorbin and SH3 domain containing 1. (1277 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1183 aa)
CLIP3CAP-Gly domain containing linker protein 3. (595 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
PRNPMajor prion protein; Belongs to the prion family. (282 aa)
ENSMODP00000045150Uncharacterized protein. (154 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PLPP1Phospholipid phosphatase 1. (286 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1064 aa)
MAGMyelin associated glycoprotein. (626 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (519 aa)
NFAM1Uncharacterized protein. (396 aa)
CDH15Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (819 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (145 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (337 aa)
APPAmyloid beta precursor protein. (717 aa)
MAL2Mal, T cell differentiation protein 2 (gene/pseudogene). (216 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (166 aa)
HAS2Uncharacterized protein. (552 aa)
ENSMODP00000042431Ig-like domain-containing protein. (187 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
ENSMODP00000041483Uncharacterized protein. (170 aa)
LOC103098388TIR domain-containing protein. (430 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (802 aa)
PODXLUncharacterized protein. (594 aa)
CBLCCbl-PTB domain-containing protein. (416 aa)
PLVAPUncharacterized protein. (320 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (806 aa)
F6XW95_MONDOP2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (567 aa)
KCNE1Uncharacterized protein. (126 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
CD4CD4. (461 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (253 aa)
CD14Uncharacterized protein. (382 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (742 aa)
NOS1Nitric oxide synthase 1. (1464 aa)
STAT6Signal transducer and activator of transcription. (839 aa)
NPC1NPC intracellular cholesterol transporter 1. (1281 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (141 aa)
ABCG2ABC transporter domain-containing protein. (661 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (803 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (585 aa)
MS4A1Membrane spanning 4-domains A1. (287 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (400 aa)
LRP4LDL receptor related protein 4. (1908 aa)
SLC1A2Amino acid transporter. (574 aa)
STOMStomatin. (285 aa)
IL6STInterleukin 6 signal transducer. (923 aa)
HCKTyrosine-protein kinase. (538 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1178 aa)
MYO1AMyosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (867 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (504 aa)
HPSEHeparanase. (544 aa)
DLC1DLC1 Rho GTPase activating protein. (1503 aa)
CAVIN3Caveolae associated protein 3. (263 aa)
TPP1Tripeptidyl peptidase 1. (569 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
TNFRSF1AUncharacterized protein. (453 aa)
BVESBlood vessel epicardial substance. (355 aa)
LDHBL-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (378 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
PPT1Palmitoyl-protein thioesterase 1. (310 aa)
AKAP6A-kinase anchoring protein 6. (2333 aa)
LCKTyrosine-protein kinase. (686 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
CD36CD36 molecule; Belongs to the CD36 family. (471 aa)
ADRA1AAdrenoceptor alpha 1A. (465 aa)
F6YPZ7_MONDOUncharacterized protein. (237 aa)
PTGISProstaglandin I2 synthase. (518 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (579 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2090 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (420 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
CLN3Battenin. (442 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
CDH13Cadherin 13. (711 aa)
CAVIN1Caveolae associated protein 1. (388 aa)
ADAM17ADAM metallopeptidase domain 17. (747 aa)
F7E823_MONDOProtein kinase domain-containing protein. (353 aa)
RFTN1Raftlin, lipid raft linker 1. (605 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (392 aa)
ARCActivity regulated cytoskeleton associated protein. (400 aa)
LRP8LDL receptor related protein 8. (854 aa)
RHOQRas homolog family member Q. (205 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1058 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (709 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
CBLBCbl proto-oncogene B. (983 aa)
PTCH1Patched 1. (1521 aa)
LYPD6LY6/PLAUR domain containing 6. (171 aa)
PLPP3acidPPc domain-containing protein. (310 aa)
LOC100028162Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (598 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (98 aa)
MLC1Modulator of VRAC current 1. (379 aa)
TNRTenascin R. (1358 aa)
BAALCUncharacterized protein. (70 aa)
ARID3AAT-rich interaction domain 3A. (627 aa)
NPHS2NPHS2 stomatin family member, podocin. (391 aa)
PLPP2Phospholipid phosphatase 2. (218 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (428 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (417 aa)
LCP2SH2 domain-containing protein. (319 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (111 aa)
MALLMal, T cell differentiation protein like. (155 aa)
STOML2Stomatin like 2. (395 aa)
SYNJ2Synaptojanin 2. (1490 aa)
ADRA1BAdrenoceptor alpha 1B. (505 aa)
TRPM8Ion_trans domain-containing protein. (691 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (706 aa)
UNC5BUnc-5 netrin receptor B. (865 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
CLN6CLN6 transmembrane ER protein. (292 aa)
AKAP5A-kinase anchoring protein 5. (454 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (921 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (629 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (975 aa)
CRKCRK proto-oncogene, adaptor protein. (297 aa)
STOML3Stomatin like 3. (291 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
ADTRPUncharacterized protein. (221 aa)
RTN4RL1Reticulon 4 receptor like 1. (442 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (719 aa)
VDAC1Voltage dependent anion channel 1. (400 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: low (22%) [HD]