(56 nodes) Negative regulation of myeloid cell differentiation network (Monodelphis domestica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GATA2	GATA binding protein 2. (473 aa)
	FBXW9	F-box and WD repeat domain containing 9. (458 aa)
	FSTL3	Follistatin like 3. (256 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
	TRIB1	Tribbles pseudokinase 1. (369 aa)
	LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component. (668 aa)
	F6YD76_MONDO	Uncharacterized protein. (527 aa)
	FBN1	Fibrillin 1. (2871 aa)
	MEIS1	Meis homeobox 1. (492 aa)
	TNFAIP6	TNF alpha induced protein 6. (277 aa)
	TNFRSF11B	TNF receptor superfamily member 11b. (433 aa)
	LOC103099707	Ig-like domain-containing protein. (354 aa)
	LYN	Tyrosine-protein kinase. (516 aa)
	GPR68	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (344 aa)
	TMEM178A	Transmembrane protein 178A. (398 aa)
	GPR137B	G protein-coupled receptor 137B. (388 aa)
	NF1	Neurofibromin 1. (2781 aa)
	MEIS2	Meis homeobox 2. (477 aa)
	ENSMODP00000055602	Uncharacterized protein. (451 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (400 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (403 aa)
	HOXA9	Hox9_act domain-containing protein. (96 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (734 aa)
	LOC100023655	Pentaxin. (223 aa)
	ZBTB46	Zinc finger and BTB domain containing 46. (666 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (390 aa)
	HOXA5	Homeobox A5. (269 aa)
	FBXW7	F-box and WD repeat domain containing 7. (892 aa)
	HOXA7	Homeobox domain-containing protein. (226 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1183 aa)
	JAM2	Uncharacterized protein. (697 aa)
	LOC100017283	C-C motif chemokine. (91 aa)
	GPR171	G protein-coupled receptor 171; Belongs to the G-protein coupled receptor 1 family. (317 aa)
	GAS2L1	Uncharacterized protein. (364 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1183 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
	CIB1	Calcium and integrin binding 1. (194 aa)
	PIAS3	Protein inhibitor of activated STAT 3. (629 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (253 aa)
	LRRC17	Leucine rich repeat containing 17. (441 aa)
	C1QC	Complement C1q C chain. (245 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (990 aa)
	LOC100012174	Signal transducer and activator of transcription. (782 aa)
	LOC100011470	Signal transducer and activator of transcription. (839 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (674 aa)
	PRMT1	Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (390 aa)
	PAF1	Uncharacterized protein. (551 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (256 aa)
	UBASH3B	Ubiquitin associated and SH3 domain containing B. (640 aa)
	TCTA	T-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (109 aa)
	CDC73	CDC73_N domain-containing protein. (371 aa)
	HSPA9	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (678 aa)
	WDR61	WD repeat domain 61. (305 aa)
	LDB1	LIM domain binding 1. (411 aa)
	CTNNB1	Catenin beta 1. (781 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC73	CTNNB1	ENSMODP00000015307	ENSMODP00000014004	CDC73_N domain-containing protein.	Catenin beta 1.	0.727
CDC73	CTR9	ENSMODP00000015307	ENSMODP00000026715	CDC73_N domain-containing protein.	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.985
CDC73	F6YD76_MONDO	ENSMODP00000015307	ENSMODP00000002829	CDC73_N domain-containing protein.	Uncharacterized protein.	0.952
CDC73	LEO1	ENSMODP00000015307	ENSMODP00000002414	CDC73_N domain-containing protein.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.999
CDC73	PAF1	ENSMODP00000015307	ENSMODP00000016869	CDC73_N domain-containing protein.	Uncharacterized protein.	0.952
CDC73	WDR61	ENSMODP00000015307	ENSMODP00000014657	CDC73_N domain-containing protein.	WD repeat domain 61.	0.982
CDK6	LYN	ENSMODP00000048851	ENSMODP00000057480	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.402
CDK6	MYC	ENSMODP00000048851	ENSMODP00000002125	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.591
CTNNB1	CDC73	ENSMODP00000014004	ENSMODP00000015307	Catenin beta 1.	CDC73_N domain-containing protein.	0.727
CTNNB1	DLL1	ENSMODP00000014004	ENSMODP00000049507	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.425
CTNNB1	ENSMODP00000055602	ENSMODP00000014004	ENSMODP00000055602	Catenin beta 1.	Uncharacterized protein.	0.727
CTNNB1	FBXW7	ENSMODP00000014004	ENSMODP00000001260	Catenin beta 1.	F-box and WD repeat domain containing 7.	0.589
CTNNB1	LEO1	ENSMODP00000014004	ENSMODP00000002414	Catenin beta 1.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.915
CTNNB1	MYC	ENSMODP00000014004	ENSMODP00000002125	Catenin beta 1.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.728
CTNNB1	PIK3R1	ENSMODP00000014004	ENSMODP00000024566	Catenin beta 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.488
CTR9	CDC73	ENSMODP00000026715	ENSMODP00000015307	CTR9 homolog, Paf1/RNA polymerase II complex component.	CDC73_N domain-containing protein.	0.985
CTR9	ENSMODP00000055602	ENSMODP00000026715	ENSMODP00000055602	CTR9 homolog, Paf1/RNA polymerase II complex component.	Uncharacterized protein.	0.980
CTR9	F6YD76_MONDO	ENSMODP00000026715	ENSMODP00000002829	CTR9 homolog, Paf1/RNA polymerase II complex component.	Uncharacterized protein.	0.985
CTR9	LEO1	ENSMODP00000026715	ENSMODP00000002414	CTR9 homolog, Paf1/RNA polymerase II complex component.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.999
CTR9	PAF1	ENSMODP00000026715	ENSMODP00000016869	CTR9 homolog, Paf1/RNA polymerase II complex component.	Uncharacterized protein.	0.985