(119 nodes) Regulation of neuron differentiation network (Monodelphis domestica)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZHX2	Zinc fingers and homeoboxes 2. (813 aa)
	F7F7P9_MONDO	Uncharacterized protein. (359 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
	FERD3L	Fer3 like bHLH transcription factor. (180 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (434 aa)
	MAP1B	Microtubule associated protein 1B. (2475 aa)
	GDF5	Growth differentiation factor 5. (495 aa)
	F7FUG2_MONDO	C2H2-type domain-containing protein. (458 aa)
	GLI3	GLI family zinc finger 3. (1501 aa)
	FEZF2	FEZ family zinc finger 2. (487 aa)
	PROX1	Prospero homeobox 1. (782 aa)
	LRRC45	Leucine rich repeat containing 45. (674 aa)
	BMP2	Bone morphogenetic protein 2. (436 aa)
	FEZ1	Fasciculation and elongation protein zeta 1. (408 aa)
	TCF3	Transcription factor 3. (544 aa)
	ZFHX2	Zinc finger homeobox 2. (2564 aa)
	CNTN4	Contactin 4. (1027 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (238 aa)
	BCL2	BCL2 apoptosis regulator. (188 aa)
	NEUROG2	Neurogenin 2. (296 aa)
	BRINP2	BMP/retinoic acid inducible neural specific 2. (782 aa)
	NKX2-5	NK2 homeobox 5. (319 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (309 aa)
	GDPD5	GP-PDE domain-containing protein. (350 aa)
	GATA2	GATA binding protein 2. (473 aa)
	ADRA2B	Adrenoceptor alpha 2B. (441 aa)
	TCF12	Transcription factor 12. (706 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	DLX2	Distal-less homeobox 2. (329 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (884 aa)
	EIF4ENIF1	Uncharacterized protein. (376 aa)
	BMP6	Bone morphogenetic protein 6. (534 aa)
	CALR	Calreticulin. (418 aa)
	ISL2	ISL LIM homeobox 2. (358 aa)
	FOXA1	Forkhead box A1. (440 aa)
	HMG20A	High mobility group 20A. (347 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1609 aa)
	BMP4	Bone morphogenetic protein 4. (410 aa)
	IRX3	Iroquois homeobox 3. (519 aa)
	DDX6	DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
	NTF4	Neurotrophin 4; Belongs to the NGF-beta family. (249 aa)
	WDR62	WD repeat domain 62. (1587 aa)
	LIN28A	Lin-28 homolog A. (205 aa)
	DIXDC1	DIX domain containing 1. (681 aa)
	NOTCH3	Notch receptor 3. (1847 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	MMD	Monocyte to macrophage differentiation associated. (238 aa)
	FEZF1	FEZ family zinc finger 1. (465 aa)
	ALK	Tyrosine-protein kinase receptor. (548 aa)
	TBX6	T-box transcription factor 6. (433 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (289 aa)
	SOX8	SRY-box transcription factor 8. (474 aa)
	FOXG1	Forkhead box G1. (492 aa)
	HEYL	Orange domain-containing protein. (237 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (341 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	NEPRO	Nucleolus and neural progenitor protein. (547 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	BEND6	BEN domain containing 6. (286 aa)
	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
	ATOH1	Atonal bHLH transcription factor 1. (380 aa)
	PRPF19	Pre-mRNA processing factor 19. (504 aa)
	TCF4	Transcription factor 4. (667 aa)
	PHOX2B	Homeobox domain-containing protein. (314 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (235 aa)
	PCP4	Purkinje cell protein 4. (62 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1276 aa)
	NCOA1	Nuclear receptor coactivator 1. (1364 aa)
	DISP3	Dispatched RND transporter family member 3. (1385 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1116 aa)
	PAX6	Paired box 6. (221 aa)
	F7B231_MONDO	BTB domain-containing protein. (272 aa)
	CTDSP1	CTD small phosphatase 1. (327 aa)
	BRINP3	BMP/retinoic acid inducible neural specific 3. (759 aa)
	F7A2H1_MONDO	Uncharacterized protein. (624 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	F6QC63_MONDO	Uncharacterized protein. (69 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	VWC2	Von Willebrand factor C domain containing 2. (339 aa)
	ZNF536	Zinc finger protein 536. (1333 aa)
	BCL11A	BAF chromatin remodeling complex subunit BCL11A. (810 aa)
	ZC4H2	Zinc finger C4H2-type containing. (304 aa)
	APP	Amyloid beta precursor protein. (717 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	MAG	Myelin associated glycoprotein. (626 aa)
	ENSMODP00000045775	SAM domain-containing protein. (300 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (285 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1219 aa)
	GDF7	TGF_BETA_2 domain-containing protein. (461 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (734 aa)
	LBX1	Homeobox domain-containing protein. (275 aa)
	MOSMO	Modulator of smoothened. (161 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (628 aa)
	HOXD3	Homeobox D3. (431 aa)
	IMPACT	Impact RWD domain protein. (337 aa)
	ZFHX3	Zinc finger homeobox 3. (3720 aa)
	ENSMODP00000053641	Uncharacterized protein. (146 aa)
	TUNAR	TCL1 upstream neural differentiation-associated RNA. (48 aa)
	TRIM32	Tripartite motif containing 32. (605 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1322 aa)
	CNTN2	Contactin 2. (1036 aa)
	SPAG9	Sperm associated antigen 9. (1317 aa)
	CNTF	Ciliary neurotrophic factor. (201 aa)
	REST	RE1 silencing transcription factor. (973 aa)
	GDF6	Growth differentiation factor 6. (505 aa)
	ECT2	Epithelial cell transforming 2. (912 aa)
	BIN1	Bridging integrator 1. (613 aa)
	SOCS2	Suppressor of cytokine signaling 2. (234 aa)
	ESRP1	Epithelial splicing regulatory protein 1. (728 aa)
	ENSMODP00000059130	Uncharacterized protein. (127 aa)
	DUOXA1	Uncharacterized protein. (371 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (343 aa)
	MMD2	Monocyte to macrophage differentiation associated 2. (322 aa)
	LTK	Tyrosine-protein kinase receptor. (952 aa)
	HOXA2	Homeobox A2. (415 aa)
	GPR37L1	G protein-coupled receptor 37 like 1. (479 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1663 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	BDNF	ENSMODP00000043145	ENSMODP00000046028	Amyloid beta precursor protein.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.544
APP	CALR	ENSMODP00000043145	ENSMODP00000014423	Amyloid beta precursor protein.	Calreticulin.	0.487
APP	CNTN2	ENSMODP00000043145	ENSMODP00000056731	Amyloid beta precursor protein.	Contactin 2.	0.774
APP	CNTN4	ENSMODP00000043145	ENSMODP00000005335	Amyloid beta precursor protein.	Contactin 4.	0.825
APP	F7F7P9_MONDO	ENSMODP00000043145	ENSMODP00000001131	Amyloid beta precursor protein.	Uncharacterized protein.	0.487
APP	ITGB1	ENSMODP00000043145	ENSMODP00000040537	Amyloid beta precursor protein.	Integrin beta; Belongs to the integrin beta chain family.	0.555
ATOH1	DLL1	ENSMODP00000024053	ENSMODP00000049507	Atonal bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.431
ATOH1	PAX6	ENSMODP00000024053	ENSMODP00000034398	Atonal bHLH transcription factor 1.	Paired box 6.	0.460
ATOH1	PHOX2B	ENSMODP00000024053	ENSMODP00000025734	Atonal bHLH transcription factor 1.	Homeobox domain-containing protein.	0.403
ATOH1	TCF12	ENSMODP00000024053	ENSMODP00000010326	Atonal bHLH transcription factor 1.	Transcription factor 12.	0.649
ATOH1	TCF3	ENSMODP00000024053	ENSMODP00000005101	Atonal bHLH transcription factor 1.	Transcription factor 3.	0.649
ATOH1	TCF4	ENSMODP00000024053	ENSMODP00000025593	Atonal bHLH transcription factor 1.	Transcription factor 4.	0.649
BCL11A	BCL11B	ENSMODP00000042447	ENSMODP00000011986	BAF chromatin remodeling complex subunit BCL11A.	BAF chromatin remodeling complex subunit BCL11B.	0.556
BCL11A	GATA2	ENSMODP00000042447	ENSMODP00000010015	BAF chromatin remodeling complex subunit BCL11A.	GATA binding protein 2.	0.475
BCL11B	BCL11A	ENSMODP00000011986	ENSMODP00000042447	BAF chromatin remodeling complex subunit BCL11B.	BAF chromatin remodeling complex subunit BCL11A.	0.556
BCL11B	PAX6	ENSMODP00000011986	ENSMODP00000034398	BAF chromatin remodeling complex subunit BCL11B.	Paired box 6.	0.409
BCL2	BDNF	ENSMODP00000006458	ENSMODP00000046028	BCL2 apoptosis regulator.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.640
BDNF	APP	ENSMODP00000046028	ENSMODP00000043145	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Amyloid beta precursor protein.	0.544
BDNF	BCL2	ENSMODP00000046028	ENSMODP00000006458	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	BCL2 apoptosis regulator.	0.640
BDNF	CNTF	ENSMODP00000046028	ENSMODP00000057482	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Ciliary neurotrophic factor.	0.791