(25 nodes) Positive regulation of epidermal growth factor receptor signaling pathway network (Monodelphis domestica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NEU3	Neuraminidase 3. (428 aa)
	FBXW7	F-box and WD repeat domain containing 7. (892 aa)
	AGR2	Uncharacterized protein. (243 aa)
	PDE6G	Phosphodiesterase 6G. (87 aa)
	BCAR3	BCAR3 adaptor protein, NSP family member. (826 aa)
	FBXW9	F-box and WD repeat domain containing 9. (458 aa)
	NCF1	Neutrophil cytosolic factor 1. (389 aa)
	SHKBP1	SH3KBP1 binding protein 1. (670 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (469 aa)
	TGFA	Transforming growth factor alpha. (159 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	HIP1R	Huntingtin interacting protein 1 related. (981 aa)
	MMP9	Matrix metallopeptidase 9. (709 aa)
	PLAUR	Uncharacterized protein. (308 aa)
	HIP1	Huntingtin interacting protein 1. (1030 aa)
	EPGN	EGF-like domain-containing protein. (152 aa)
	CCDC88A	Coiled-coil domain containing 88A. (1829 aa)
	NEURL1	Neuralized E3 ubiquitin protein ligase 1. (577 aa)
	AFAP1L2	Actin filament associated protein 1 like 2. (893 aa)
	AREG	Amphiregulin. (237 aa)
	EREG	Epiregulin. (179 aa)
	PDE6H	Phosphodiesterase 6H. (76 aa)
	CNOT9	CCR4-NOT transcription complex subunit 9. (299 aa)
	ADAM17	ADAM metallopeptidase domain 17. (747 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM17	AREG	ENSMODP00000018410	ENSMODP00000023962	ADAM metallopeptidase domain 17.	Amphiregulin.	0.437
ADAM17	HBEGF	ENSMODP00000018410	ENSMODP00000014655	ADAM metallopeptidase domain 17.	Heparin binding EGF like growth factor.	0.438
ADAM17	TGFA	ENSMODP00000018410	ENSMODP00000014471	ADAM metallopeptidase domain 17.	Transforming growth factor alpha.	0.593
AGT	MMP9	ENSMODP00000011483	ENSMODP00000017178	Angiotensinogen; Belongs to the serpin family.	Matrix metallopeptidase 9.	0.452
AGT	NCF1	ENSMODP00000011483	ENSMODP00000008622	Angiotensinogen; Belongs to the serpin family.	Neutrophil cytosolic factor 1.	0.405
AREG	ADAM17	ENSMODP00000023962	ENSMODP00000018410	Amphiregulin.	ADAM metallopeptidase domain 17.	0.437
AREG	EPGN	ENSMODP00000023962	ENSMODP00000053380	Amphiregulin.	EGF-like domain-containing protein.	0.715
AREG	EREG	ENSMODP00000023962	ENSMODP00000023961	Amphiregulin.	Epiregulin.	0.862
AREG	HBEGF	ENSMODP00000023962	ENSMODP00000014655	Amphiregulin.	Heparin binding EGF like growth factor.	0.529
AREG	TGFA	ENSMODP00000023962	ENSMODP00000014471	Amphiregulin.	Transforming growth factor alpha.	0.749
EPGN	AREG	ENSMODP00000053380	ENSMODP00000023962	EGF-like domain-containing protein.	Amphiregulin.	0.715
EPGN	EREG	ENSMODP00000053380	ENSMODP00000023961	EGF-like domain-containing protein.	Epiregulin.	0.725
EPGN	HBEGF	ENSMODP00000053380	ENSMODP00000014655	EGF-like domain-containing protein.	Heparin binding EGF like growth factor.	0.713
EPGN	TGFA	ENSMODP00000053380	ENSMODP00000014471	EGF-like domain-containing protein.	Transforming growth factor alpha.	0.524
EREG	AREG	ENSMODP00000023961	ENSMODP00000023962	Epiregulin.	Amphiregulin.	0.862
EREG	EPGN	ENSMODP00000023961	ENSMODP00000053380	Epiregulin.	EGF-like domain-containing protein.	0.725
EREG	HBEGF	ENSMODP00000023961	ENSMODP00000014655	Epiregulin.	Heparin binding EGF like growth factor.	0.757
EREG	TGFA	ENSMODP00000023961	ENSMODP00000014471	Epiregulin.	Transforming growth factor alpha.	0.702
HBEGF	ADAM17	ENSMODP00000014655	ENSMODP00000018410	Heparin binding EGF like growth factor.	ADAM metallopeptidase domain 17.	0.438
HBEGF	AREG	ENSMODP00000014655	ENSMODP00000023962	Heparin binding EGF like growth factor.	Amphiregulin.	0.529