(21 nodes) Response to pain network (Monodelphis domestica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RELN	Reelin. (3458 aa)
	MTOR	Serine/threonine-protein kinase mTOR. (1040 aa)
	P2RX2-2	Uncharacterized protein. (64 aa)
	PIRT	Phosphoinositide interacting regulator of transient receptor potential channels. (176 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
	VWA1	Von Willebrand factor A domain containing 1. (495 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1123 aa)
	NMUR2	Neuromedin U receptor 2. (404 aa)
	F7BA89_MONDO	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (740 aa)
	TACR1	Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (409 aa)
	GCH1	GTP cyclohydrolase 1. (355 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (390 aa)
	DBH	Dopamine beta-hydroxylase. (614 aa)
	P2RX2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (473 aa)
	TAC1	Tachykinin precursor 1. (120 aa)
	NTRK1	Tyrosine-protein kinase receptor. (739 aa)
	LPAR5	Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	THBS4	Thrombospondin 4. (955 aa)
	P2RX3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (400 aa)
	UCN	Urocortin. (130 aa)
	THBS1	Thrombospondin 1. (1197 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DBH	TAC1	ENSMODP00000016277	ENSMODP00000020552	Dopamine beta-hydroxylase.	Tachykinin precursor 1.	0.414
F7BA89_MONDO	MTOR	ENSMODP00000013940	ENSMODP00000057648	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase mTOR.	0.925
MTOR	F7BA89_MONDO	ENSMODP00000057648	ENSMODP00000013940	Serine/threonine-protein kinase mTOR.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.925
P2RX2	P2RX3	ENSMODP00000018938	ENSMODP00000025108	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.697
P2RX2	P2RX4	ENSMODP00000018938	ENSMODP00000015042	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.502
P2RX2-2	P2RX3	ENSMODP00000059469	ENSMODP00000025108	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.686
P2RX2-2	P2RX4	ENSMODP00000059469	ENSMODP00000015042	Uncharacterized protein.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.476
P2RX3	P2RX2	ENSMODP00000025108	ENSMODP00000018938	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.697
P2RX3	P2RX2-2	ENSMODP00000025108	ENSMODP00000059469	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Uncharacterized protein.	0.686
P2RX3	P2RX4	ENSMODP00000025108	ENSMODP00000015042	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.572
P2RX3	TRPA1	ENSMODP00000025108	ENSMODP00000008943	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.406
P2RX4	P2RX2	ENSMODP00000015042	ENSMODP00000018938	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.502
P2RX4	P2RX2-2	ENSMODP00000015042	ENSMODP00000059469	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Uncharacterized protein.	0.476
P2RX4	P2RX3	ENSMODP00000015042	ENSMODP00000025108	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.572
TAC1	DBH	ENSMODP00000020552	ENSMODP00000016277	Tachykinin precursor 1.	Dopamine beta-hydroxylase.	0.414
TAC1	TACR1	ENSMODP00000020552	ENSMODP00000014105	Tachykinin precursor 1.	Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.864
TAC1	TRPA1	ENSMODP00000020552	ENSMODP00000008943	Tachykinin precursor 1.	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.512
TACR1	TAC1	ENSMODP00000014105	ENSMODP00000020552	Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family.	Tachykinin precursor 1.	0.864
TRPA1	P2RX3	ENSMODP00000008943	ENSMODP00000025108	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.406
TRPA1	TAC1	ENSMODP00000008943	ENSMODP00000020552	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.	Tachykinin precursor 1.	0.512