STRINGSTRING
PKD1 PKD1 PKDCC PKDCC HOXA13 HOXA13 HOXA5 HOXA5 KLF5 KLF5 SFRP2 SFRP2 EDNRB EDNRB AGR2 AGR2 PDGFC PDGFC CCDC40 CCDC40 GLI3 GLI3 RARRES2 RARRES2 TGFB2 TGFB2 FOXF1 FOXF1 HLX HLX DNAAF1 DNAAF1 SHH SHH BCL2 BCL2 WNT11 WNT11 MIXL1 MIXL1 CHD8 CHD8 SOX9 SOX9 DACT1 DACT1 MYOCD MYOCD FOXF2 FOXF2 ALDH1A2 ALDH1A2 HIF1A HIF1A PDX1 PDX1 CDX2 CDX2 COBL COBL LGR4 LGR4 HOXD13 HOXD13 SMAD2 SMAD2 STRA6 STRA6 COL3A1 COL3A1 RB1 RB1 CTNNB1 CTNNB1 CCDC103 CCDC103 YIPF6 YIPF6 GATA4 GATA4 NODAL NODAL SAV1 SAV1 SALL1 SALL1 SMO SMO TP63 TP63 IHH IHH IFT172 IFT172 TNF TNF ADA ADA GATA5 GATA5 TCF21 TCF21 CRKL CRKL CLDN18 CLDN18 SOX10 SOX10 CXCL8 CXCL8 IL6ST IL6ST NIPBL NIPBL PDGFRA PDGFRA CCDC39 CCDC39 KIT KIT F6RWE3_MONDO F6RWE3_MONDO EPB41L5 EPB41L5 ALX4 ALX4 ENSMODP00000041484 ENSMODP00000041484 LOC100017154 LOC100017154 VPS52 VPS52 CLMP CLMP NPHP3 NPHP3 TIGAR TIGAR ENSMODP00000044858 ENSMODP00000044858 ASS1 ASS1 CPS1 CPS1 ENSMODP00000045583 ENSMODP00000045583 PCSK5 PCSK5 ENSMODP00000046830 ENSMODP00000046830 SMAD3 SMAD3 RBPMS2 RBPMS2 SPDEF SPDEF GATA6 GATA6 NKX3-2 NKX3-2 PRDM1 PRDM1 AHI1 AHI1 ENSMODP00000056683 ENSMODP00000056683 ENSMODP00000057195 ENSMODP00000057195 ENSMODP00000057314 ENSMODP00000057314 NKX2-3 NKX2-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKD1Polycystin 1, transient receptor potential channel interacting. (4343 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (490 aa)
HOXA13Homeobox A13. (399 aa)
HOXA5Homeobox A5. (269 aa)
KLF5Kruppel like factor 5. (464 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (434 aa)
AGR2Uncharacterized protein. (243 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
CCDC40Uncharacterized protein. (1088 aa)
GLI3GLI family zinc finger 3. (1501 aa)
RARRES2Retinoic acid receptor responder 2. (172 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
FOXF1Forkhead box F1. (378 aa)
HLXH2.0 like homeobox. (486 aa)
DNAAF1Dynein assembly factor 1, axonemal. (643 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (480 aa)
BCL2BCL2 apoptosis regulator. (188 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa)
MIXL1Mix paired-like homeobox. (246 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2591 aa)
SOX9SRY-box transcription factor 9. (512 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (851 aa)
MYOCDMyocardin. (903 aa)
FOXF2Forkhead box F2. (482 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (830 aa)
PDX1Homeobox domain-containing protein. (290 aa)
CDX2Caudal type homeobox 2. (302 aa)
COBLUncharacterized protein. (894 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
HOXD13Homeobox D13. (340 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
STRA6Stimulated by retinoic acid 6. (684 aa)
COL3A1Collagen type III alpha 1 chain. (1461 aa)
RB1RB transcriptional corepressor 1. (937 aa)
CTNNB1Catenin beta 1. (781 aa)
CCDC103Coiled-coil domain containing 103. (241 aa)
YIPF6Protein YIPF. (239 aa)
GATA4GATA binding protein 4. (451 aa)
NODALNodal growth differentiation factor. (347 aa)
SAV1Salvador family WW domain containing protein 1. (397 aa)
SALL1Spalt like transcription factor 1. (1309 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
IFT172Intraflagellar transport 172. (1753 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
ADAAdenosine deaminase. (334 aa)
GATA5GATA binding protein 5. (397 aa)
TCF21Transcription factor 21. (179 aa)
CRKLUncharacterized protein. (303 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (253 aa)
SOX10SRY-box transcription factor 10. (576 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IL6STInterleukin 6 signal transducer. (923 aa)
NIPBLNipped-B protein. (2911 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
CCDC39Coiled-coil domain containing 39. (935 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
F6RWE3_MONDOUncharacterized protein. (545 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (729 aa)
ALX4ALX homeobox 4. (417 aa)
ENSMODP00000041484Uncharacterized protein. (86 aa)
LOC100017154Uncharacterized protein. (390 aa)
VPS52VPS52 subunit of GARP complex. (650 aa)
CLMPCXADR like membrane protein. (415 aa)
NPHP3TPR_REGION domain-containing protein. (1334 aa)
TIGARUncharacterized protein. (269 aa)
ENSMODP00000044858A_deaminase domain-containing protein. (83 aa)
ASS1Argininosuccinate synthase 1. (438 aa)
CPS1Carbamoyl-phosphate synthase 1. (1525 aa)
ENSMODP00000045583A_deaminase domain-containing protein. (79 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1873 aa)
ENSMODP00000046830Homeobox domain-containing protein. (345 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
RBPMS2RRM domain-containing protein. (358 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (378 aa)
GATA6GATA binding protein 6. (651 aa)
NKX3-2NK3 homeobox 2. (323 aa)
PRDM1PR/SET domain 1. (829 aa)
AHI1Abelson helper integration site 1. (1237 aa)
ENSMODP00000056683Cobl domain-containing protein. (442 aa)
ENSMODP00000057195SH2 domain-containing protein. (119 aa)
ENSMODP00000057314Uncharacterized protein. (425 aa)
NKX2-3NK2 homeobox 3. (345 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.