STRINGSTRING
SAV1 SAV1 ST8SIA1 ST8SIA1 IFT57 IFT57 EAF2 EAF2 A4GNT A4GNT FGF2 FGF2 FGL1 FGL1 EREG EREG AREG AREG FST FST H9H7D8_MONDO H9H7D8_MONDO ITGB1BP1 ITGB1BP1 LGR5 LGR5 PHOX2B PHOX2B KDR KDR STAT6 STAT6 LOXL2 LOXL2 HSF4 HSF4 NRARP NRARP SFN SFN ZEB1 ZEB1 IQGAP3 IQGAP3 EHF EHF LOXL3 LOXL3 F6SBA9_MONDO F6SBA9_MONDO STK11 STK11 PHB2 PHB2 LOC100010425 LOC100010425 STK3 STK3 SDR16C5 SDR16C5 NCSTN NCSTN BMPR1A BMPR1A SCARB1 SCARB1 BAD BAD MEF2C MEF2C LOC100029952 LOC100029952 WDR77 WDR77 CAV2 CAV2 RPS6KA1 RPS6KA1 C6orf89 C6orf89 COL8A1 COL8A1 BAX BAX STK4 STK4 CCND1 CCND1 FGF1 FGF1 SMO SMO KDF1 KDF1 DRD2 DRD2 BAK1 BAK1 TRIM24 TRIM24 PPARD PPARD IGFBP4 IGFBP4 HGF HGF MED1 MED1 NKX2-8 NKX2-8 TGFBR1 TGFBR1 AR AR PURA PURA TGFA TGFA RB1 RB1 IFT52 IFT52 BTRC BTRC EYA1 EYA1 MKI67 MKI67 PRKX PRKX PIK3CB PIK3CB MTSS1 MTSS1 PROK1 PROK1 IFT74 IFT74 OVOL1 OVOL1 PROK2 PROK2 NF1 NF1 PSEN1 PSEN1 EFNB2 EFNB2 FGF7 FGF7 SERPINF1 SERPINF1 THAP1 THAP1 FSHB FSHB LGR4 LGR4 NOX5 NOX5 PDX1 PDX1 CYP7B1 CYP7B1 TGFB1 TGFB1 XBP1 XBP1 TEK TEK HLX HLX FLCN FLCN ESRP2 ESRP2 SERPINB1 SERPINB1 NKX2-5 NKX2-5 BMPER BMPER DACH1 DACH1 MTA3 MTA3 WNT2B WNT2B IL6 IL6 FSHR FSHR VSTM4 VSTM4 PTCH1 PTCH1 PROX1 PROX1 EPHA2 EPHA2 LOXL4 LOXL4 FERMT1 FERMT1 CCN3 CCN3 B4GALT1 B4GALT1 F6VW21_MONDO F6VW21_MONDO TNFSF11 TNFSF11 CDH13 CDH13 TP63 TP63 GPC3 GPC3 WNT16 WNT16 IGFBP5 IGFBP5 IFT172 IFT172 TNF TNF WNT2 WNT2 CAV1 CAV1 BMPR2 BMPR2 CEBPB CEBPB IFT80 IFT80 ESR1 ESR1 NKX3-1 NKX3-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SAV1Salvador family WW domain containing protein 1. (397 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (426 aa)
IFT57Intraflagellar transport 57. (431 aa)
EAF2ELL associated factor 2. (262 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (329 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
FGL1Fibrinogen like 1. (311 aa)
EREGEpiregulin. (179 aa)
AREGAmphiregulin. (237 aa)
FSTFollistatin. (343 aa)
H9H7D8_MONDOLipase; Belongs to the AB hydrolase superfamily. Lipase family. (398 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (910 aa)
PHOX2BHomeobox domain-containing protein. (314 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
STAT6Signal transducer and activator of transcription. (839 aa)
LOXL2Lysyl oxidase like 2. (713 aa)
HSF4HSF_DOMAIN domain-containing protein. (534 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
SFNStratifin; Belongs to the 14-3-3 family. (256 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1116 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1631 aa)
EHFETS homologous factor. (279 aa)
LOXL3Lysyl oxidase like 3. (756 aa)
F6SBA9_MONDOThyroglobulin type-1 domain-containing protein. (77 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (414 aa)
PHB2Prohibitin. (299 aa)
LOC100010425Resistin like beta. (132 aa)
STK3Serine/threonine kinase 3. (555 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
NCSTNNicastrin. (790 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (519 aa)
BADUncharacterized protein. (212 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LOC100029952Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (351 aa)
WDR77WD repeat domain 77. (432 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
RPS6KA1Ribosomal protein S6 kinase. (740 aa)
C6orf89Chromosome 6 open reading frame 89. (391 aa)
COL8A1C1q domain-containing protein. (740 aa)
BAXUncharacterized protein. (296 aa)
STK4Serine/threonine kinase 4. (496 aa)
CCND1Uncharacterized protein. (67 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
KDF1Keratinocyte differentiation factor 1. (415 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (415 aa)
BAK1BCL2 antagonist/killer 1. (204 aa)
TRIM24Tripartite motif containing 24. (1060 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
IGFBP4Insulin like growth factor binding protein 4. (260 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1609 aa)
NKX2-8NK2 homeobox 8. (287 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
ARAndrogen receptor. (960 aa)
PURAPurine rich element binding protein A. (374 aa)
TGFATransforming growth factor alpha. (159 aa)
RB1RB transcriptional corepressor 1. (937 aa)
IFT52Intraflagellar transport 52. (485 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (628 aa)
MKI67FHA domain-containing protein. (2851 aa)
PRKXUncharacterized protein. (419 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
MTSS1MTSS I-BAR domain containing 1. (797 aa)
PROK1Prokineticin domain-containing protein. (105 aa)
IFT74Intraflagellar transport 74. (657 aa)
OVOL1Uncharacterized protein. (267 aa)
PROK2Prokineticin 2. (111 aa)
NF1Neurofibromin 1. (2781 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)
EFNB2Ephrin RBD domain-containing protein; Belongs to the ephrin family. (333 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (455 aa)
THAP1THAP domain containing 1. (213 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
NOX5NADPH oxidase 5. (745 aa)
PDX1Homeobox domain-containing protein. (290 aa)
CYP7B1Uncharacterized protein; Belongs to the cytochrome P450 family. (462 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
XBP1X-box binding protein 1. (204 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
HLXH2.0 like homeobox. (486 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
ESRP2Epithelial splicing regulatory protein 2. (650 aa)
SERPINB1Serpin family B member 1; Belongs to the serpin family. (381 aa)
NKX2-5NK2 homeobox 5. (319 aa)
BMPERBMP binding endothelial regulator. (686 aa)
DACH1Dachshund family transcription factor 1. (784 aa)
MTA3Metastasis associated 1 family member 3. (609 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
IL6Uncharacterized protein. (220 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (700 aa)
VSTM4V-set and transmembrane domain containing 4. (319 aa)
PTCH1Patched 1. (1521 aa)
PROX1Prospero homeobox 1. (782 aa)
EPHA2EPH receptor A2. (886 aa)
LOXL4Lysyl oxidase like 4. (752 aa)
FERMT1Fermitin family member 1. (680 aa)
CCN3Cellular communication network factor 3. (361 aa)
B4GALT1Uncharacterized protein. (384 aa)
F6VW21_MONDOCyclin_C domain-containing protein. (89 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
CDH13Cadherin 13. (711 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (486 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
IGFBP5Uncharacterized protein. (310 aa)
IFT172Intraflagellar transport 172. (1753 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
CEBPBCCAAT enhancer binding protein beta. (364 aa)
IFT80Intraflagellar transport 80. (721 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
NKX3-1NK3 homeobox 1. (258 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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