(18 nodes) Defense response to fungus network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
	IL17RA	SEFIR domain-containing protein. (517 aa)
	IL17RC	SEFIR domain-containing protein. (726 aa)
	FAM3A	Family with sequence similarity 3 member A. (270 aa)
	BCL10	CARD domain-containing protein. (245 aa)
	S100A12	EF-hand domain-containing protein. (112 aa)
	RNASE8	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (242 aa)
	IL17A	Interleukin 17A. (153 aa)
	CARD9	Uncharacterized protein. (377 aa)
	HRG	Uncharacterized protein. (538 aa)
	IL36RN	Interleukin-1. (143 aa)
	IL1RN	Interleukin-1. (174 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	CLEC4E	C-type lectin domain family 4 member E. (224 aa)
	JAGN1	Jagunal homolog 1. (183 aa)
	COTL1	Coactosin like F-actin binding protein 1. (142 aa)
	SPON2	Spondin 2. (330 aa)
	RARRES2	Retinoic acid receptor responder 2. (172 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL10	CARD9	ENSMODP00000052151	ENSMODP00000021908	CARD domain-containing protein.	Uncharacterized protein.	0.991
CARD9	BCL10	ENSMODP00000021908	ENSMODP00000052151	Uncharacterized protein.	CARD domain-containing protein.	0.991
CARD9	CLEC4E	ENSMODP00000021908	ENSMODP00000009099	Uncharacterized protein.	C-type lectin domain family 4 member E.	0.576
CLEC4E	CARD9	ENSMODP00000009099	ENSMODP00000021908	C-type lectin domain family 4 member E.	Uncharacterized protein.	0.576
CLEC4E	PLCG2	ENSMODP00000009099	ENSMODP00000018986	C-type lectin domain family 4 member E.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.436
IL17A	IL17RA	ENSMODP00000023476	ENSMODP00000056387	Interleukin 17A.	SEFIR domain-containing protein.	0.996
IL17A	IL17RC	ENSMODP00000023476	ENSMODP00000055106	Interleukin 17A.	SEFIR domain-containing protein.	0.993
IL17RA	IL17A	ENSMODP00000056387	ENSMODP00000023476	SEFIR domain-containing protein.	Interleukin 17A.	0.996
IL17RA	IL17RC	ENSMODP00000056387	ENSMODP00000055106	SEFIR domain-containing protein.	SEFIR domain-containing protein.	0.980
IL17RC	IL17A	ENSMODP00000055106	ENSMODP00000023476	SEFIR domain-containing protein.	Interleukin 17A.	0.993
IL17RC	IL17RA	ENSMODP00000055106	ENSMODP00000056387	SEFIR domain-containing protein.	SEFIR domain-containing protein.	0.980
PLCG2	CLEC4E	ENSMODP00000018986	ENSMODP00000009099	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	C-type lectin domain family 4 member E.	0.436