STRINGSTRING
PPM1F PPM1F MAPK1 MAPK1 RYK RYK SEMA6C SEMA6C PLA2G7 PLA2G7 FGF2 FGF2 VEGFA VEGFA CCL5 CCL5 MMP28 MMP28 CXCL8 CXCL8 IL16 IL16 SEMA4B SEMA4B C5 C5 THBS4 THBS4 PDGFRA PDGFRA KDR KDR STAP1 STAP1 USP14 USP14 ZNF580 ZNF580 SEMA4C SEMA4C CSF1 CSF1 TRPV4 TRPV4 LOC100028680 LOC100028680 TNFAIP6 TNFAIP6 GAS6 GAS6 VEGFC VEGFC CCN3 CCN3 F7 F7 FGF4 FGF4 SLIT1 SLIT1 TIRAP TIRAP SEMA4F SEMA4F TBR1 TBR1 SMOC2 SMOC2 TMEM102 TMEM102 C5AR2 C5AR2 CREB3 CREB3 NRP1 NRP1 CCL21 CCL21 GPR183 GPR183 GPR18 GPR18 SWAP70 SWAP70 LOC100020486 LOC100020486 TGFB1 TGFB1 ADAM10 ADAM10 C5AR1 C5AR1 MPP1 MPP1 VAX1 VAX1 PDGFB PDGFB CSF1R CSF1R CXCL12 CXCL12 SLAMF8 SLAMF8 CX3CR1 CX3CR1 IL12A IL12A CCR1 CCR1 SEMA3G SEMA3G CALR CALR MSTN MSTN RIPOR2 RIPOR2 SEMA4G SEMA4G P2RX4 P2RX4 ANGPT2 ANGPT2 SEMA3B SEMA3B SEMA3F SEMA3F NOD2 NOD2 CCR7 CCR7 ST6GAL1 ST6GAL1 HSPB1 HSPB1 DEF6 DEF6 WNT3A WNT3A PTN PTN IL34 IL34 CXCL14 CXCL14 F7E823_MONDO F7E823_MONDO ADAM17 ADAM17 GPSM3 GPSM3 AGER AGER CDH13 CDH13 MAPK3 MAPK3 MET MET HRG HRG PTK2B PTK2B BMPR2 BMPR2 CAMK1D CAMK1D YTHDF1 YTHDF1 SEMA4A SEMA4A SEMA3E SEMA3E SEMA3C SEMA3C VEGFD VEGFD S100A14 S100A14 PRKD1 PRKD1 F6WLE6_MONDO F6WLE6_MONDO F7F7P9_MONDO F7F7P9_MONDO BST1 BST1 STX4 STX4 LGMN LGMN FEZF2 FEZF2 SEMA6D SEMA6D LOC100018887 LOC100018887 ARTN ARTN SLC8B1 SLC8B1 RARRES2 RARRES2 LOC100028775 LOC100028775 TNFSF14 TNFSF14 CCR3 CCR3 OXSR1 OXSR1 GREM1 GREM1 C1QBP C1QBP SEMA3A SEMA3A NTRK3 NTRK3 SCG2 SCG2 SEMA5B SEMA5B SEMA7A SEMA7A F7AQZ1_MONDO F7AQZ1_MONDO F7DKL8_MONDO F7DKL8_MONDO ROBO2-2 ROBO2-2 CCL19 CCL19 LOC100017283 LOC100017283 DPP4 DPP4 LOC103096620 LOC103096620 CD74 CD74 EDN2 EDN2 AKIRIN1 AKIRIN1 ROBO2 ROBO2 NEDD9 NEDD9 ENSMODP00000042114 ENSMODP00000042114 STK39 STK39 PADI2 PADI2 WNT3 WNT3 ROBO1 ROBO1 THBS1 THBS1 WNK1 WNK1 MYCBP2 MYCBP2 ENSMODP00000045584 ENSMODP00000045584 CXCR4 CXCR4 ADGRA2 ADGRA2 SERPINE1 SERPINE1 STX3 STX3 SLIT2 SLIT2 SEMA6A SEMA6A CCR6 CCR6 MST1 MST1 PGF PGF CMKLR1 CMKLR1 SEMA4D SEMA4D FGF1 FGF1 SEMA5A SEMA5A MOSPD2 MOSPD2 CXCL13 CXCL13 FAM49B FAM49B MCU MCU CCL27 CCL27 RIN3 RIN3 PTK2 PTK2 PTPN2 PTPN2 DNM1L DNM1L C3AR1 C3AR1 FGF18 FGF18 ENSMODP00000057314 ENSMODP00000057314 LYN LYN ENSMODP00000058116 ENSMODP00000058116 ENSMODP00000058344 ENSMODP00000058344 EFNB2 EFNB2 LOC103099055 LOC103099055 ENSMODP00000059161 ENSMODP00000059161 ENSMODP00000059267 ENSMODP00000059267 SEMA3D SEMA3D JAM3 JAM3 ENSMODP00000059541 ENSMODP00000059541 KLRK1 KLRK1 NTF3 NTF3 VEGFB VEGFB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (447 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
RYKReceptor like tyrosine kinase. (630 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (973 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (434 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
CCL5C-C motif chemokine ligand 5. (91 aa)
MMP28Matrix metallopeptidase 28. (525 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1474 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (818 aa)
C5Complement C5. (1638 aa)
THBS4Thrombospondin 4. (955 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
STAP1Signal transducing adaptor family member 1. (338 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (496 aa)
ZNF580Zinc finger protein 580. (169 aa)
SEMA4CUncharacterized protein; Belongs to the semaphorin family. (832 aa)
CSF1Uncharacterized protein. (340 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4. (640 aa)
LOC100028680G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
GAS6Growth arrest specific 6. (677 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (351 aa)
CCN3Cellular communication network factor 3. (361 aa)
F7Coagulation factor VII. (442 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
SLIT1Slit guidance ligand 1. (1515 aa)
TIRAPTIR domain-containing protein. (342 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (795 aa)
TBR1T-box brain transcription factor 1. (679 aa)
SMOC2SPARC related modular calcium binding 2. (482 aa)
TMEM102Transmembrane protein 102. (573 aa)
C5AR2Complement component 5a receptor 2. (352 aa)
CREB3BZIP domain-containing protein. (370 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (922 aa)
CCL21C-C motif chemokine ligand 21. (138 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (355 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (330 aa)
SWAP70Switching B cell complex subunit SWAP70. (585 aa)
LOC100020486Uncharacterized protein; Belongs to the parvalbumin family. (122 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
C5AR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (345 aa)
MPP1Membrane palmitoylated protein 1; Belongs to the MAGUK family. (472 aa)
VAX1Ventral anterior homeobox 1. (326 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (959 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (89 aa)
SLAMF8SLAM family member 8. (279 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (760 aa)
CALRCalreticulin. (418 aa)
MSTNMyostatin. (432 aa)
RIPOR2PL48 domain-containing protein. (1046 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (840 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (390 aa)
ANGPT2Angiopoietin 2. (495 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (764 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (726 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1012 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
ST6GAL1ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (427 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (256 aa)
DEF6DEF6 guanine nucleotide exchange factor. (660 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
PTNPleiotrophin. (168 aa)
IL34Uncharacterized protein. (279 aa)
CXCL14C-X-C motif chemokine ligand 14. (99 aa)
F7E823_MONDOProtein kinase domain-containing protein. (353 aa)
ADAM17ADAM metallopeptidase domain 17. (747 aa)
GPSM3G protein signaling modulator 3. (159 aa)
AGERAdvanced glycosylation end-product specific receptor. (406 aa)
CDH13Cadherin 13. (711 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1387 aa)
HRGUncharacterized protein. (538 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (392 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (601 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (790 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (715 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (753 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
S100A14S100 calcium binding protein A14; Belongs to the S-100 family. (104 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (861 aa)
F6WLE6_MONDOFocal_AT domain-containing protein. (115 aa)
F7F7P9_MONDOUncharacterized protein. (359 aa)
BST1Bone marrow stromal cell antigen 1. (349 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (297 aa)
LGMNLegumain. (437 aa)
FEZF2FEZ family zinc finger 2. (487 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1066 aa)
LOC100018887SCY domain-containing protein. (120 aa)
ARTNTGF_BETA_2 domain-containing protein. (278 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (579 aa)
RARRES2Retinoic acid receptor responder 2. (172 aa)
LOC100028775G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
TNFSF14TNF superfamily member 14; Belongs to the tumor necrosis factor family. (227 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (356 aa)
OXSR1Protein kinase domain-containing protein. (551 aa)
GREM1Gremlin. (184 aa)
C1QBPComplement C1q binding protein. (315 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
SCG2Secretogranin II. (624 aa)
SEMA5BSemaphorin 5B. (1092 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (675 aa)
F7AQZ1_MONDOSCY domain-containing protein. (144 aa)
F7DKL8_MONDOUncharacterized protein. (408 aa)
ROBO2-2Ig-like domain-containing protein. (121 aa)
CCL19C-C motif chemokine. (96 aa)
LOC100017283C-C motif chemokine. (91 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (806 aa)
LOC103096620SCY domain-containing protein. (103 aa)
CD74CD74 molecule. (281 aa)
EDN2Uncharacterized protein. (178 aa)
AKIRIN1Uncharacterized protein. (196 aa)
ROBO2Roundabout guidance receptor 2. (1284 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
ENSMODP00000042114SCY domain-containing protein. (97 aa)
STK39Serine/threonine kinase 39. (570 aa)
PADI2Peptidyl arginine deiminase 2. (665 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ROBO1Roundabout guidance receptor 1. (1732 aa)
THBS1Thrombospondin 1. (1197 aa)
WNK1WNK lysine deficient protein kinase 1. (2867 aa)
MYCBP2MYC binding protein 2. (4761 aa)
ENSMODP00000045584G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1324 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (413 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (289 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1045 aa)
CCR6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (712 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (207 aa)
CMKLR1Chemerin chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (737 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
SEMA5ASemaphorin 5A. (1083 aa)
MOSPD2Motile sperm domain containing 2. (589 aa)
CXCL13SCY domain-containing protein. (111 aa)
FAM49BFamily with sequence similarity 49 member B. (599 aa)
MCUMitochondrial calcium uniporter. (353 aa)
CCL27SCY domain-containing protein. (128 aa)
RIN3Uncharacterized protein. (231 aa)
PTK2Uncharacterized protein. (161 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (403 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (778 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (488 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
ENSMODP00000057314Uncharacterized protein. (425 aa)
LYNTyrosine-protein kinase. (516 aa)
ENSMODP00000058116G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
ENSMODP00000058344G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (359 aa)
EFNB2Ephrin RBD domain-containing protein; Belongs to the ephrin family. (333 aa)
LOC103099055Uncharacterized protein; Belongs to the semaphorin family. (776 aa)
ENSMODP00000059161FERM domain-containing protein. (121 aa)
ENSMODP00000059267Uncharacterized protein. (127 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (778 aa)
JAM3Junctional adhesion molecule 3. (340 aa)
ENSMODP00000059541Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (693 aa)
KLRK1C-type lectin domain-containing protein. (238 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (343 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (568 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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