(24 nodes) Regulation of nitric-oxide synthase activity network (Monodelphis domestica)

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Predicted Interactions

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Your Input:
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
	APOE	Uncharacterized protein. (299 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (242 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (519 aa)
	ENSMODP00000043447	EF-hand domain-containing protein; Belongs to the S-100 family. (72 aa)
	F6QHP1_MONDO	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1274 aa)
	CNR2	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (347 aa)
	TERF2	Telomeric repeat binding factor 2. (540 aa)
	NPR3	Natriuretic peptide receptor 3. (531 aa)
	NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit. (300 aa)
	S100A1	Protein S100; Belongs to the S-100 family. (94 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	FCER2	C-type lectin domain-containing protein. (342 aa)
	NOSIP	Nitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family. (301 aa)
	GCH1	GTP cyclohydrolase 1. (355 aa)
	GLA	Alpha-galactosidase. (462 aa)
	HTR2B	5-hydroxytryptamine receptor 2B; Belongs to the G-protein coupled receptor 1 family. (473 aa)
	EGFR	Receptor protein-tyrosine kinase. (1213 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1058 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (938 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOE	CAV1	ENSMODP00000057511	ENSMODP00000019745	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.418
APOE	IL1B	ENSMODP00000057511	ENSMODP00000017267	Uncharacterized protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.502
APOE	SCARB1	ENSMODP00000057511	ENSMODP00000044237	Uncharacterized protein.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.677
CAV1	APOE	ENSMODP00000019745	ENSMODP00000057511	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.418
CAV1	CAV3	ENSMODP00000019745	ENSMODP00000049955	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.969
CAV1	EGFR	ENSMODP00000019745	ENSMODP00000011264	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein-tyrosine kinase.	0.920
CAV1	ESR1	ENSMODP00000019745	ENSMODP00000020873	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.848
CAV1	SCARB1	ENSMODP00000019745	ENSMODP00000044237	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.627
CAV3	CAV1	ENSMODP00000049955	ENSMODP00000019745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.969
CAV3	EGFR	ENSMODP00000049955	ENSMODP00000011264	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein-tyrosine kinase.	0.432
CAV3	ESR1	ENSMODP00000049955	ENSMODP00000020873	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.452
EGFR	CAV1	ENSMODP00000011264	ENSMODP00000019745	Receptor protein-tyrosine kinase.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.920
EGFR	CAV3	ENSMODP00000011264	ENSMODP00000049955	Receptor protein-tyrosine kinase.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.432
EGFR	ESR1	ENSMODP00000011264	ENSMODP00000020873	Receptor protein-tyrosine kinase.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.837
EGFR	IL1B	ENSMODP00000011264	ENSMODP00000017267	Receptor protein-tyrosine kinase.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.547
EGFR	LEP	ENSMODP00000011264	ENSMODP00000044791	Receptor protein-tyrosine kinase.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.813
EGFR	PIK3CB	ENSMODP00000011264	ENSMODP00000053456	Receptor protein-tyrosine kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.968
EGFR	PTK2B	ENSMODP00000011264	ENSMODP00000019886	Receptor protein-tyrosine kinase.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.504
ESR1	CAV1	ENSMODP00000020873	ENSMODP00000019745	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.848
ESR1	CAV3	ENSMODP00000020873	ENSMODP00000049955	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.452