STRINGSTRING
PAK6 PAK6 PTK7 PTK7 AREG AREG LOC100015455 LOC100015455 LHX2 LHX2 CSF1 CSF1 CYFIP2 CYFIP2 ULK1 ULK1 SEMA3A SEMA3A BDNF BDNF LLPH LLPH JADE2 JADE2 APP APP EFNA5 EFNA5 EDN2 EDN2 LAMB2 LAMB2 ITGB1 ITGB1 EPB41L5 EPB41L5 STK11 STK11 RAPH1 RAPH1 SEMA7A SEMA7A ALCAM ALCAM SEMA5B SEMA5B SPG11 SPG11 SSNA1 SSNA1 ESR1 ESR1 AURKA AURKA DDR1 DDR1 TGFBR2 TGFBR2 RND2 RND2 SH3GL2 SH3GL2 LIMK1 LIMK1 NRN1L NRN1L NIN NIN ENSMODP00000056683 ENSMODP00000056683 IMPACT IMPACT HDAC6 HDAC6 ENSMODP00000053169 ENSMODP00000053169 SPRY1 SPRY1 DCLK1 DCLK1 SEMA5A SEMA5A FGF1 FGF1 NRN1 NRN1 NRP2 NRP2 ENSMODP00000048326 ENSMODP00000048326 SALL1 SALL1 MED1 MED1 SEMA3F SEMA3F LZTS2 LZTS2 CTNNB1 CTNNB1 ULK2 ULK2 EDN1 EDN1 ITGA4 ITGA4 SPART SPART HOXD13 HOXD13 BIN3 BIN3 COBL COBL TGFB1 TGFB1 SPAG6 SPAG6 UBAP1 UBAP1 MST1 MST1 SLIT3 SLIT3 VCL VCL TMEM108 TMEM108 KIF26B KIF26B SLIT2 SLIT2 WASF1 WASF1 NRP1 NRP1 RDH10 RDH10 AUTS2 AUTS2 DVL1 DVL1 WNT11 WNT11 TNR TNR FLRT3 FLRT3 SLIT1 SLIT1 C9orf72 C9orf72 IST1 IST1 MAP1B MAP1B SFRP2 SFRP2 KDM5B KDM5B EDNRA EDNRA EIF2AK4 EIF2AK4 CYFIP1 CYFIP1 TNN TNN RYK RYK SRF SRF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK6P21 (RAC1) activated kinase 6. (592 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
AREGAmphiregulin. (237 aa)
LOC100015455BHLH domain-containing protein. (262 aa)
LHX2LIM homeobox 2. (408 aa)
CSF1Uncharacterized protein. (340 aa)
CYFIP2Cytoplasmic FMR1 interacting protein 2. (1138 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1013 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (285 aa)
LLPHLLP homolog, long-term synaptic facilitation factor. (138 aa)
JADE2Jade family PHD finger 2. (864 aa)
APPAmyloid beta precursor protein. (717 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
EDN2Uncharacterized protein. (178 aa)
LAMB2Laminin subunit beta 2. (1807 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (802 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (729 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (414 aa)
RAPH1Uncharacterized protein. (617 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (675 aa)
ALCAMActivated leukocyte cell adhesion molecule. (582 aa)
SEMA5BSemaphorin 5B. (1092 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2446 aa)
SSNA1SS nuclear autoantigen 1. (118 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (488 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (911 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
RND2Rho family GTPase 2. (231 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
LIMK1LIM domain kinase 1. (602 aa)
NRN1LNeuritin 1 like. (170 aa)
NINNinein. (1833 aa)
ENSMODP00000056683Cobl domain-containing protein. (442 aa)
IMPACTImpact RWD domain protein. (337 aa)
HDAC6Histone deacetylase 6. (1106 aa)
ENSMODP00000053169Uncharacterized protein. (59 aa)
SPRY1Uncharacterized protein. (105 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
SEMA5ASemaphorin 5A. (1083 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
NRN1Uncharacterized protein. (86 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
ENSMODP00000048326Uncharacterized protein. (89 aa)
SALL1Spalt like transcription factor 1. (1309 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1609 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (726 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (758 aa)
CTNNB1Catenin beta 1. (781 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1041 aa)
EDN1Endothelin 1. (214 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
SPARTSpartin. (670 aa)
HOXD13Homeobox D13. (340 aa)
BIN3Bridging integrator 3. (253 aa)
COBLUncharacterized protein. (894 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
SPAG6Sperm associated antigen 6. (508 aa)
UBAP1Ubiquitin associated protein 1. (506 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (712 aa)
SLIT3Slit guidance ligand 3. (1532 aa)
VCLVinculin. (1147 aa)
TMEM108Uncharacterized protein. (105 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2116 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
WASF1WASP family member 1. (546 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (922 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1051 aa)
DVL1Dishevelled segment polarity protein 1. (705 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa)
TNRTenascin R. (1358 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
SLIT1Slit guidance ligand 1. (1515 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
IST1IST1 factor associated with ESCRT-III. (371 aa)
MAP1BMicrotubule associated protein 1B. (2475 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
KDM5BLysine demethylase 5B. (1567 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1663 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
TNNTenascin N. (1473 aa)
RYKReceptor like tyrosine kinase. (630 aa)
SRFSerum response factor. (490 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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