(31 nodes) Regulation of morphogenesis of a branching structure network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
	SOX8	SRY-box transcription factor 8. (474 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	GDNF	Glial cell derived neurotrophic factor. (183 aa)
	GREM1	Gremlin. (184 aa)
	PHB2	Prohibitin. (299 aa)
	BCL11A	BAF chromatin remodeling complex subunit BCL11A. (810 aa)
	BTBD7	BTB domain containing 7. (1122 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (242 aa)
	SIX1	SIX homeobox 1. (284 aa)
	HOXB7	Homeobox domain-containing protein. (217 aa)
	FKBPL	FKBP prolyl isomerase like. (318 aa)
	RTN4	Reticulon. (1217 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
	SIX2	SIX homeobox 2. (383 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SULF1	Sulfatase 1. (1125 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	HOXD13	Homeobox D13. (340 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (469 aa)
	SIX4	SIX homeobox 4. (788 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	NTN4	Netrin 4. (589 aa)
	LOC100026375	Uncharacterized protein. (636 aa)
	AR	Androgen receptor. (960 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	TGFB1	ENSMODP00000011483	ENSMODP00000010737	Angiotensinogen; Belongs to the serpin family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.564
AGT	TNF	ENSMODP00000011483	ENSMODP00000019686	Angiotensinogen; Belongs to the serpin family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.525
AR	CTNNB1	ENSMODP00000015542	ENSMODP00000014004	Androgen receptor.	Catenin beta 1.	0.909
AR	ESR1	ENSMODP00000015542	ENSMODP00000020873	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.706
BTBD7	SNAI2	ENSMODP00000045111	ENSMODP00000012734	BTB domain containing 7.	Snail family transcriptional repressor 2.	0.403
CAV3	CTNNB1	ENSMODP00000049955	ENSMODP00000014004	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta 1.	0.544
CAV3	ESR1	ENSMODP00000049955	ENSMODP00000020873	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.452
CTNNB1	AR	ENSMODP00000014004	ENSMODP00000015542	Catenin beta 1.	Androgen receptor.	0.909
CTNNB1	CAV3	ENSMODP00000014004	ENSMODP00000049955	Catenin beta 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.544
CTNNB1	ESR1	ENSMODP00000014004	ENSMODP00000020873	Catenin beta 1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.661
CTNNB1	SMO	ENSMODP00000014004	ENSMODP00000018347	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.473
CTNNB1	SNAI2	ENSMODP00000014004	ENSMODP00000012734	Catenin beta 1.	Snail family transcriptional repressor 2.	0.543
CTNNB1	SOX8	ENSMODP00000014004	ENSMODP00000021089	Catenin beta 1.	SRY-box transcription factor 8.	0.555
CTNNB1	TGFB1	ENSMODP00000014004	ENSMODP00000010737	Catenin beta 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.542
CTNNB1	TNF	ENSMODP00000014004	ENSMODP00000019686	Catenin beta 1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.405
CTNNB1	WNT2	ENSMODP00000014004	ENSMODP00000019704	Catenin beta 1.	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).	0.583
CTNNB1	WNT2B	ENSMODP00000014004	ENSMODP00000001433	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.583
ESR1	AR	ENSMODP00000020873	ENSMODP00000015542	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Androgen receptor.	0.706
ESR1	CAV3	ENSMODP00000020873	ENSMODP00000049955	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.452
ESR1	CTNNB1	ENSMODP00000020873	ENSMODP00000014004	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Catenin beta 1.	0.661