(87 nodes) Positive regulation of small molecule metabolic process network (Monodelphis domestica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (481 aa)
	PODN	Podocan. (634 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)
	PARK7	DJ-1_PfpI domain-containing protein. (189 aa)
	APOE	Uncharacterized protein. (299 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
	APOA5	Apolipoprotein A5. (370 aa)
	ENSMODP00000056404	Uncharacterized protein. (59 aa)
	CLYBL	Citrate lyase beta like. (354 aa)
	PRXL2C	Uncharacterized protein. (263 aa)
	ENSMODP00000055083	Uncharacterized protein. (59 aa)
	MLXIPL	Uncharacterized protein. (260 aa)
	ENSMODP00000054035	Uncharacterized protein. (83 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (403 aa)
	ENSMODP00000052120	Uncharacterized protein. (56 aa)
	DAB2	DAB adaptor protein 2. (772 aa)
	EPM2AIP1	Uncharacterized protein. (614 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (900 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
	ENSMODP00000049100	Uncharacterized protein. (565 aa)
	STARD4	START domain-containing protein. (207 aa)
	NCS1	Neuronal calcium sensor 1. (190 aa)
	GCK	Phosphotransferase. (532 aa)
	GUCA2A	Uncharacterized protein. (132 aa)
	APOC2	Uncharacterized protein. (235 aa)
	SORBS1	Sorbin and SH3 domain containing 1. (1277 aa)
	LPGAT1	Lysophosphatidylglycerol acyltransferase 1. (384 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (337 aa)
	APP	Amyloid beta precursor protein. (717 aa)
	KAT2A	Lysine acetyltransferase 2A. (712 aa)
	CD74	CD74 molecule. (281 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (414 aa)
	CD244	Ig-like domain-containing protein. (377 aa)
	F6XW95_MONDO	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (567 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (984 aa)
	MID1IP1	MID1 interacting protein 1. (173 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (203 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (402 aa)
	KAT2B	Lysine acetyltransferase 2B. (862 aa)
	NOS1	Nitric oxide synthase 1. (1464 aa)
	ABCG1	ABC transporter domain-containing protein. (664 aa)
	DDB1	Damage specific DNA binding protein 1. (1026 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (442 aa)
	ELOVL5	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (295 aa)
	ABCD2	ATP binding cassette subfamily D member 2. (740 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (749 aa)
	GUCA1C	Guanylate cyclase activator 1C. (196 aa)
	BEND3	BEN domain containing 3. (835 aa)
	GUCA2B	Uncharacterized protein. (109 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (713 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1142 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
	INSR	Tyrosine-protein kinase receptor. (1378 aa)
	MLYCD	Malonyl-CoA decarboxylase. (547 aa)
	SCAP	SREBF chaperone. (1287 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
	APOA4	Uncharacterized protein. (371 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (256 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (652 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (622 aa)
	GUCA1A	Uncharacterized protein. (201 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (623 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (608 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (469 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (338 aa)
	BMP6	Bone morphogenetic protein 6. (534 aa)
	PLA2G3	Uncharacterized protein. (688 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (830 aa)
	PTH	Uncharacterized protein. (137 aa)
	ABCD1	ATP binding cassette subfamily D member 1. (776 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (897 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	MAS1	MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (486 aa)
	HNF1A	HNF1 homeobox A. (613 aa)
	IGF1	Insulin like growth factor 1. (225 aa)
	ANXA1	Annexin. (346 aa)
	AVPR1B	Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
	SLC45A3	Solute carrier family 45 member 3. (552 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (795 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD1	HNF1A	ENSMODP00000010355	ENSMODP00000003604	ATP binding cassette subfamily D member 1.	HNF1 homeobox A.	0.444
ABCD2	HNF1A	ENSMODP00000023116	ENSMODP00000003604	ATP binding cassette subfamily D member 2.	HNF1 homeobox A.	0.444
ABCG1	APOE	ENSMODP00000026284	ENSMODP00000057511	ABC transporter domain-containing protein.	Uncharacterized protein.	0.609
ABCG1	NR1H3	ENSMODP00000026284	ENSMODP00000024834	ABC transporter domain-containing protein.	Nuclear receptor subfamily 1 group H member 3.	0.469
ABCG1	PPARG	ENSMODP00000026284	ENSMODP00000007730	ABC transporter domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.458
ABCG1	SREBF1	ENSMODP00000026284	ENSMODP00000037870	ABC transporter domain-containing protein.	Sterol regulatory element binding transcription factor 1.	0.463
ABCG1	SREBF2	ENSMODP00000026284	ENSMODP00000020735	ABC transporter domain-containing protein.	Sterol regulatory element binding transcription factor 2.	0.544
ADCYAP1R1	PTH	ENSMODP00000043365	ENSMODP00000010873	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.403
ADIPOQ	APOE	ENSMODP00000016761	ENSMODP00000057511	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.406
ADIPOQ	IL1B	ENSMODP00000016761	ENSMODP00000017267	Adiponectin, C1Q and collagen domain containing.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.524
ADIPOQ	PPARA	ENSMODP00000016761	ENSMODP00000009135	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator activated receptor alpha.	0.631
ADIPOQ	PPARG	ENSMODP00000016761	ENSMODP00000007730	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.693
ADIPOQ	PPARGC1A	ENSMODP00000016761	ENSMODP00000000664	Adiponectin, C1Q and collagen domain containing.	PPARG coactivator 1 alpha.	0.614
ADIPOQ	SIRT1	ENSMODP00000016761	ENSMODP00000021523	Adiponectin, C1Q and collagen domain containing.	Deacetylase sirtuin-type domain-containing protein.	0.553
ADIPOQ	SREBF1	ENSMODP00000016761	ENSMODP00000037870	Adiponectin, C1Q and collagen domain containing.	Sterol regulatory element binding transcription factor 1.	0.405
ADIPOQ	TNF	ENSMODP00000016761	ENSMODP00000019686	Adiponectin, C1Q and collagen domain containing.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.545
ANXA1	APP	ENSMODP00000002656	ENSMODP00000043145	Annexin.	Amyloid beta precursor protein.	0.514
ANXA1	IL1B	ENSMODP00000002656	ENSMODP00000017267	Annexin.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.419
APOA4	APOA5	ENSMODP00000017253	ENSMODP00000056676	Uncharacterized protein.	Apolipoprotein A5.	0.719
APOA4	APOC2	ENSMODP00000017253	ENSMODP00000047437	Uncharacterized protein.	Uncharacterized protein.	0.902