(30 nodes) Neuron cellular homeostasis network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (585 aa)
	ENSMODP00000047599	Uncharacterized protein. (59 aa)
	APP	Amyloid beta precursor protein. (717 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	MAP1A	Microtubule associated protein 1A. (2896 aa)
	CHMP2B	Charged multivesicular body protein 2B. (214 aa)
	CX3CL1	SCY domain-containing protein. (409 aa)
	F7EH84_MONDO	Uncharacterized protein. (217 aa)
	CHRNA1	Cholinergic receptor nicotinic alpha 1 subunit. (457 aa)
	ATP2B3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1073 aa)
	CALB1	Calbindin 1. (261 aa)
	CA7	Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (264 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	HEXB	Beta-hexosaminidase. (538 aa)
	HAAO	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (371 aa)
	TYRO3	TYRO3 protein tyrosine kinase. (820 aa)
	PARK2	RBR-type E3 ubiquitin transferase. (74 aa)
	FGGY	FGGY_C domain-containing protein. (221 aa)
	F6TDG8_MONDO	Uncharacterized protein. (89 aa)
	CALB2	Calbindin 2. (264 aa)
	IMMT	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (760 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)
	ATP2B2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1223 aa)
	TMEM175	Transmembrane protein 175. (502 aa)
	DISC1	Uncharacterized protein. (901 aa)
	DCTN1	CAP-Gly domain-containing protein. (1270 aa)
	ENSMODP00000050667	Ubiquitin-like domain-containing protein. (89 aa)
	BAP1	BRCA1 associated protein 1. (754 aa)
	ENSMODP00000048841	FGGY_N domain-containing protein. (119 aa)
	ENSMODP00000047678	FGGY_C domain-containing protein. (150 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	DISC1	ENSMODP00000043145	ENSMODP00000054450	Amyloid beta precursor protein.	Uncharacterized protein.	0.585
APP	PARK2	ENSMODP00000043145	ENSMODP00000039734	Amyloid beta precursor protein.	RBR-type E3 ubiquitin transferase.	0.429
APP	PSEN1	ENSMODP00000043145	ENSMODP00000057945	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.972
BAP1	ENSMODP00000047678	ENSMODP00000050460	ENSMODP00000047678	BRCA1 associated protein 1.	FGGY_C domain-containing protein.	0.437
BAP1	ENSMODP00000048841	ENSMODP00000050460	ENSMODP00000048841	BRCA1 associated protein 1.	FGGY_N domain-containing protein.	0.437
BAP1	FGGY	ENSMODP00000050460	ENSMODP00000037054	BRCA1 associated protein 1.	FGGY_C domain-containing protein.	0.437
DISC1	APP	ENSMODP00000054450	ENSMODP00000043145	Uncharacterized protein.	Amyloid beta precursor protein.	0.585
ENSMODP00000047599	P2RY4	ENSMODP00000047599	ENSMODP00000005850	Uncharacterized protein.	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family.	0.440
ENSMODP00000047678	BAP1	ENSMODP00000047678	ENSMODP00000050460	FGGY_C domain-containing protein.	BRCA1 associated protein 1.	0.437
ENSMODP00000047678	ENSMODP00000048841	ENSMODP00000047678	ENSMODP00000048841	FGGY_C domain-containing protein.	FGGY_N domain-containing protein.	0.759
ENSMODP00000047678	FGGY	ENSMODP00000047678	ENSMODP00000037054	FGGY_C domain-containing protein.	FGGY_C domain-containing protein.	0.946
ENSMODP00000048841	BAP1	ENSMODP00000048841	ENSMODP00000050460	FGGY_N domain-containing protein.	BRCA1 associated protein 1.	0.437
ENSMODP00000048841	ENSMODP00000047678	ENSMODP00000048841	ENSMODP00000047678	FGGY_N domain-containing protein.	FGGY_C domain-containing protein.	0.759
ENSMODP00000048841	FGGY	ENSMODP00000048841	ENSMODP00000037054	FGGY_N domain-containing protein.	FGGY_C domain-containing protein.	0.936
FGGY	BAP1	ENSMODP00000037054	ENSMODP00000050460	FGGY_C domain-containing protein.	BRCA1 associated protein 1.	0.437
FGGY	ENSMODP00000047678	ENSMODP00000037054	ENSMODP00000047678	FGGY_C domain-containing protein.	FGGY_C domain-containing protein.	0.946
FGGY	ENSMODP00000048841	ENSMODP00000037054	ENSMODP00000048841	FGGY_C domain-containing protein.	FGGY_N domain-containing protein.	0.936
P2RX1	P2RY4	ENSMODP00000025655	ENSMODP00000005850	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family.	0.440
P2RY4	ENSMODP00000047599	ENSMODP00000005850	ENSMODP00000047599	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.440
P2RY4	P2RX1	ENSMODP00000005850	ENSMODP00000025655	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	0.440