53 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (663 aa)
	ENSMODP00000053416	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1450 aa)
	FAM172A	Family with sequence similarity 172 member A. (440 aa)
	ENSMODP00000056464	H15 domain-containing protein. (154 aa)
	DNMT3L	PHD-type domain-containing protein. (449 aa)
	L3MBTL1	SAM domain-containing protein. (895 aa)
	SETD7	SET domain containing 7, histone lysine methyltransferase. (227 aa)
	HAT1	Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
	SPTY2D1	Uncharacterized protein. (644 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1514 aa)
	F6ZD21_MONDO	Uncharacterized protein. (597 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (608 aa)
	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1732 aa)
	POLE3	CBFD_NFYB_HMF domain-containing protein. (146 aa)
	MBD3	Uncharacterized protein. (308 aa)
	LOXL4	Lysyl oxidase like 4. (752 aa)
	LOC100016550	Uncharacterized protein. (365 aa)
	F6YRI3_MONDO	Uncharacterized protein. (647 aa)
	RB1	RB transcriptional corepressor 1. (937 aa)
	MBD2	Methyl-CpG binding domain protein 2. (416 aa)
	SETDB2	SET domain bifurcated histone lysine methyltransferase 2. (717 aa)
	F6SQ78_MONDO	GFA domain-containing protein. (257 aa)
	MECP2	Methyl-CpG binding protein 2. (537 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (601 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (794 aa)
	LMNB1	Uncharacterized protein; Belongs to the intermediate filament family. (338 aa)
	NRM	Uncharacterized protein. (115 aa)
	HP1BP3	Heterochromatin protein 1 binding protein 3. (559 aa)
	ZNFX1	Zinc finger NFX1-type containing 1. (1923 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (684 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (713 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (450 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	BEND3	BEN domain containing 3. (835 aa)
	SETDB1	SET domain bifurcated histone lysine methyltransferase 1. (1420 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1694 aa)
	SMCHD1	SMC hinge domain-containing protein. (612 aa)
	LOXL2	Lysyl oxidase like 2. (713 aa)
	EZH2	Uncharacterized protein. (665 aa)
	MECOM	MDS1 and EVI1 complex locus. (1114 aa)
	F7CAM4_MONDO	Uncharacterized protein. (122 aa)
	LOXL3	Lysyl oxidase like 3. (756 aa)
	TNP1	Transition protein 1. (55 aa)
	K7E0A4_MONDO	Uncharacterized protein. (667 aa)
	RIF1	Replication timing regulatory factor 1. (2408 aa)
	LOC103099173	IF rod domain-containing protein; Belongs to the intermediate filament family. (238 aa)
	AXIN1	Axin 1. (875 aa)
	PRDM16	Uncharacterized protein. (143 aa)
	ENSMODP00000042313	Uncharacterized protein. (84 aa)
	BAHD1	Bromo adjacent homology domain containing 1. (710 aa)
	LOC100022062	Uncharacterized protein. (728 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (399 aa)
	ENSMODP00000047016	Uncharacterized protein. (91 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAHD1	SMCHD1	ENSMODP00000042479	ENSMODP00000026823	Bromo adjacent homology domain containing 1.	SMC hinge domain-containing protein.	0.405
DNMT1	DNMT3L	ENSMODP00000006657	ENSMODP00000057178	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	PHD-type domain-containing protein.	0.671
DNMT1	ENSMODP00000042313	ENSMODP00000006657	ENSMODP00000042313	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.682
DNMT1	ENSMODP00000053416	ENSMODP00000006657	ENSMODP00000053416	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.900
DNMT1	EZH1	ENSMODP00000006657	ENSMODP00000018795	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.616
DNMT1	EZH2	ENSMODP00000006657	ENSMODP00000033725	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.682
DNMT1	F6YRI3_MONDO	ENSMODP00000006657	ENSMODP00000001250	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.682
DNMT1	HDAC1	ENSMODP00000006657	ENSMODP00000021783	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.681
DNMT1	HDAC2	ENSMODP00000006657	ENSMODP00000022264	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.681
DNMT1	K7E0A4_MONDO	ENSMODP00000006657	ENSMODP00000039205	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.682
DNMT1	MBD2	ENSMODP00000006657	ENSMODP00000013828	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG binding domain protein 2.	0.427
DNMT1	MBD3	ENSMODP00000006657	ENSMODP00000005076	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.427
DNMT1	MECP2	ENSMODP00000006657	ENSMODP00000014588	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG binding protein 2.	0.575
DNMT1	SETD7	ENSMODP00000006657	ENSMODP00000000137	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	SET domain containing 7, histone lysine methyltransferase.	0.561
DNMT1	SETDB1	ENSMODP00000006657	ENSMODP00000023474	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	SET domain bifurcated histone lysine methyltransferase 1.	0.550
DNMT1	SIRT1	ENSMODP00000006657	ENSMODP00000021523	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Deacetylase sirtuin-type domain-containing protein.	0.455
DNMT3L	DNMT1	ENSMODP00000057178	ENSMODP00000006657	PHD-type domain-containing protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.671
DNMT3L	ENSMODP00000053416	ENSMODP00000057178	ENSMODP00000053416	PHD-type domain-containing protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.436
DNMT3L	HDAC1	ENSMODP00000057178	ENSMODP00000021783	PHD-type domain-containing protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.444
DNMT3L	HDAC2	ENSMODP00000057178	ENSMODP00000022264	PHD-type domain-containing protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.444