52 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BBC3	Uncharacterized protein. (318 aa)
	INO80	INO80 complex ATPase subunit. (1558 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (168 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	F6YM83_MONDO	Uncharacterized protein. (527 aa)
	ITGB6	Integrin beta; Belongs to the integrin beta chain family. (788 aa)
	NUCKS1	Uncharacterized protein. (243 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	RAD9A	Cell cycle checkpoint control protein; Belongs to the rad9 family. (461 aa)
	GTF2H5	General transcription factor IIH subunit 5. (71 aa)
	CHEK2	Checkpoint kinase 2. (531 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	MAP3K20	Mitogen-activated protein kinase kinase kinase 20. (805 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	TLK2	Tousled like kinase 2. (750 aa)
	F6ZF24_MONDO	Uncharacterized protein. (381 aa)
	F7CKG5_MONDO	HSF_DOMAIN domain-containing protein. (525 aa)
	RAD9B	Cell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1840 aa)
	F6YFM4_MONDO	Uncharacterized protein. (109 aa)
	BARD1	BRCA1 associated RING domain 1. (799 aa)
	KDM1A	Lysine demethylase 1A. (909 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (713 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (476 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1882 aa)
	ATM	TAN domain-containing protein. (112 aa)
	CRYAB	Crystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (182 aa)
	RHNO1	RAD9-HUS1-RAD1 interacting nuclear orphan 1. (247 aa)
	RAD51AP1	RAD51_interact domain-containing protein. (373 aa)
	SPIDR	DUF4502 domain-containing protein. (235 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (527 aa)
	ECT2	Epithelial cell transforming 2. (912 aa)
	TANK	TRAF family member associated NFKB activator. (473 aa)
	ATR	Uncharacterized protein. (159 aa)
	ENSMODP00000051881	ETS domain-containing protein. (526 aa)
	XRCC6	X-ray repair cross complementing 6. (633 aa)
	BABAM2	BRISC and BRCA1 A complex member 2. (407 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (701 aa)
	K7E3R2_MONDO	DH domain-containing protein. (411 aa)
	INTS7	Integrator complex subunit 7. (961 aa)
	WRN	WRN RecQ like helicase. (1333 aa)
	LIG4	DNA ligase. (911 aa)
	NET1	Uncharacterized protein. (542 aa)
	BRCA2	Tower domain-containing protein. (3324 aa)
	RAD1	RAD1 checkpoint DNA exonuclease. (281 aa)
	NIPBL	Nipped-B protein. (2911 aa)
	TMEM109	Transmembrane protein 109. (260 aa)
	FBXO4	F-box protein 4. (387 aa)
	TNKS1BP1	Tankyrase_bdg_C domain-containing protein. (1636 aa)
	BLM	BLM RecQ like helicase. (1451 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSMODP00000059879	ENSMODP00000052412	TAN domain-containing protein.	Uncharacterized protein.	0.999
ATM	BABAM2	ENSMODP00000059879	ENSMODP00000048843	TAN domain-containing protein.	BRISC and BRCA1 A complex member 2.	0.649
ATM	BARD1	ENSMODP00000059879	ENSMODP00000019509	TAN domain-containing protein.	BRCA1 associated RING domain 1.	0.978
ATM	BLM	ENSMODP00000059879	ENSMODP00000024262	TAN domain-containing protein.	BLM RecQ like helicase.	0.925
ATM	BRCA1	ENSMODP00000059879	ENSMODP00000018933	TAN domain-containing protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.996
ATM	BRCA2	ENSMODP00000059879	ENSMODP00000033276	TAN domain-containing protein.	Tower domain-containing protein.	0.930
ATM	CHEK2	ENSMODP00000059879	ENSMODP00000010421	TAN domain-containing protein.	Checkpoint kinase 2.	0.997
ATM	LIG4	ENSMODP00000059879	ENSMODP00000036738	TAN domain-containing protein.	DNA ligase.	0.749
ATM	RAD1	ENSMODP00000059879	ENSMODP00000025503	TAN domain-containing protein.	RAD1 checkpoint DNA exonuclease.	0.917
ATM	RAD51	ENSMODP00000059879	ENSMODP00000000325	TAN domain-containing protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.958
ATM	RAD51AP1	ENSMODP00000059879	ENSMODP00000022813	TAN domain-containing protein.	RAD51_interact domain-containing protein.	0.527
ATM	RAD9A	ENSMODP00000059879	ENSMODP00000009534	TAN domain-containing protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.860
ATM	RAD9B	ENSMODP00000059879	ENSMODP00000014472	TAN domain-containing protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.860
ATM	RHNO1	ENSMODP00000059879	ENSMODP00000022872	TAN domain-containing protein.	RAD9-HUS1-RAD1 interacting nuclear orphan 1.	0.572
ATM	SIRT1	ENSMODP00000059879	ENSMODP00000021523	TAN domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.637
ATM	TP53BP1	ENSMODP00000059879	ENSMODP00000022200	TAN domain-containing protein.	Tumor protein p53 binding protein 1.	0.979
ATM	WRN	ENSMODP00000059879	ENSMODP00000037910	TAN domain-containing protein.	WRN RecQ like helicase.	0.988
ATM	XRCC5	ENSMODP00000059879	ENSMODP00000047042	TAN domain-containing protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.936
ATM	XRCC6	ENSMODP00000059879	ENSMODP00000050498	TAN domain-containing protein.	X-ray repair cross complementing 6.	0.950
ATR	ATM	ENSMODP00000052412	ENSMODP00000059879	Uncharacterized protein.	TAN domain-containing protein.	0.999