(93 nodes) Cellular response to toxic substance network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APOM	Apolipoprotein M. (192 aa)
	MGST2	Microsomal glutathione S-transferase 2. (164 aa)
	ENSMODP00000059522	GLOBIN domain-containing protein; Belongs to the globin family. (135 aa)
	ENSMODP00000057895	AhpC-TSA domain-containing protein. (193 aa)
	PARK7	DJ-1_PfpI domain-containing protein. (189 aa)
	SELENOS	Selenoprotein S. (182 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)
	PIM1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (296 aa)
	F6UVW9_MONDO	Uncharacterized protein. (215 aa)
	TPO	Thyroid peroxidase. (863 aa)
	PXDN	Peroxidasin. (1488 aa)
	LPO	Lactoperoxidase. (664 aa)
	ABCB6	ATP binding cassette subfamily B member 6 (Langereis blood group). (844 aa)
	LOC100618776	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues. (183 aa)
	LOC100016060	GLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
	LOC100019238	EF-hand domain-containing protein; Belongs to the S-100 family. (91 aa)
	LOC100019177	Protein S100; Belongs to the S-100 family. (125 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (608 aa)
	ESD	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)
	UBIAD1	UbiA prenyltransferase domain containing 1. (343 aa)
	OPRD1	Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	SESN2	Sestrin 2. (478 aa)
	F7GFP7_MONDO	Uncharacterized protein. (451 aa)
	MGST1	Microsomal glutathione S-transferase 1. (155 aa)
	TXNRD2	Thioredoxin reductase 2; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (448 aa)
	SRXN1	Sulfiredoxin. (160 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (177 aa)
	SELENOT	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
	PRDX6	Thioredoxin domain-containing protein. (224 aa)
	LTC4S	Leukotriene C4 synthase. (192 aa)
	GLRX	Glutaredoxin domain-containing protein. (106 aa)
	APOE	Uncharacterized protein. (299 aa)
	PXDNL	Peroxidasin like. (1466 aa)
	GPX2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
	FABP1	FABP domain-containing protein. (86 aa)
	CYGB	Cytoglobin; Belongs to the globin family. (304 aa)
	IPCEF1	PH domain-containing protein. (428 aa)
	PRXL2B	Peroxiredoxin like 2B. (201 aa)
	SELENOF	Uncharacterized protein. (93 aa)
	CCS	Copper chaperone for superoxide dismutase. (282 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
	PRDX5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (254 aa)
	TP53INP1	Uncharacterized protein. (220 aa)
	GPX4	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (181 aa)
	DUOX1	Dual oxidase 1. (1542 aa)
	RDH12	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
	LOC100022164	Uncharacterized protein; Belongs to the GST superfamily. (242 aa)
	EPX	Eosinophil peroxidase. (717 aa)
	ENSMODP00000050014	1-cysPrx_C domain-containing protein. (95 aa)
	ENSMODP00000049836	1-cysPrx_C domain-containing protein. (124 aa)
	GSR	Glutathione-disulfide reductase. (513 aa)
	PRDX3	Thioredoxin domain-containing protein. (268 aa)
	ENSMODP00000047583	Uncharacterized protein. (68 aa)
	ALDH1A1	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (549 aa)
	SESN1	Sestrin 1. (514 aa)
	ENSMODP00000045019	Uncharacterized protein. (217 aa)
	TXNRD3	Thioredoxin reductase 3; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (674 aa)
	ENSMODP00000044892	EGF-like domain-containing protein. (331 aa)
	TXNL1	Thioredoxin like 1. (292 aa)
	GPX3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (238 aa)
	LOC100012330	Uncharacterized protein. (493 aa)
	PRDX4	Peroxiredoxin 4. (279 aa)
	PARK2	RBR-type E3 ubiquitin transferase. (74 aa)
	PTGS1	EGF-like domain-containing protein. (663 aa)
	GSTK1	Glutathione S-transferase kappa. (249 aa)
	FANCC	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (585 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
	SELENOW	Selenoprotein W. (89 aa)
	F6TDG8_MONDO	Uncharacterized protein. (89 aa)
	F7FSD8_MONDO	Uncharacterized protein. (160 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (157 aa)
	SOD3	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (262 aa)
	MGST3	Microsomal glutathione S-transferase 3. (154 aa)
	MFSD11	Major facilitator superfamily domain containing 11. (465 aa)
	F6UZL6_MONDO	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (129 aa)
	AKR1A1	Aldo-keto reductase family 1 member A1. (324 aa)
	PRDX1	Thioredoxin domain-containing protein. (225 aa)
	HP	Uncharacterized protein; Belongs to the peptidase S1 family. (416 aa)
	NQO1	NAD(P)H quinone dehydrogenase 1. (274 aa)
	ENSMODP00000050667	Ubiquitin-like domain-containing protein. (89 aa)
	PTGES	Uncharacterized protein. (235 aa)
	ENSMODP00000051284	Uncharacterized protein. (661 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (529 aa)
	LOC100024619	MOSC domain-containing protein. (354 aa)
	ENSMODP00000053238	Uncharacterized protein. (147 aa)
	PRDX2	Peroxiredoxin 2. (198 aa)
	PINK1	Protein kinase domain-containing protein. (573 aa)
	CLIC2	GST N-terminal domain-containing protein. (244 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
	PRXL2C	Uncharacterized protein. (263 aa)
	LOC100022188	Uncharacterized protein; Belongs to the GST superfamily. (252 aa)
	RDH11	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (329 aa)
	PRXL2A	Uncharacterized protein. (298 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A1	CAT	ENSMODP00000046329	ENSMODP00000052701	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	0.423
ALDH1A1	RDH11	ENSMODP00000046329	ENSMODP00000056310	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.927
ALDH1A1	RDH12	ENSMODP00000046329	ENSMODP00000012528	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.927
APOE	APOM	ENSMODP00000057511	ENSMODP00000056876	Uncharacterized protein.	Apolipoprotein M.	0.730
APOE	SELENOS	ENSMODP00000057511	ENSMODP00000015072	Uncharacterized protein.	Selenoprotein S.	0.400
APOE	UBIAD1	ENSMODP00000057511	ENSMODP00000013872	Uncharacterized protein.	UbiA prenyltransferase domain containing 1.	0.631
APOM	APOE	ENSMODP00000056876	ENSMODP00000057511	Apolipoprotein M.	Uncharacterized protein.	0.730
APOM	HP	ENSMODP00000056876	ENSMODP00000003024	Apolipoprotein M.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.403
CAT	ALDH1A1	ENSMODP00000052701	ENSMODP00000046329	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	0.423
CAT	ENSMODP00000047583	ENSMODP00000052701	ENSMODP00000047583	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Uncharacterized protein.	0.486
CAT	ENSMODP00000049836	ENSMODP00000052701	ENSMODP00000049836	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	1-cysPrx_C domain-containing protein.	0.632
CAT	ENSMODP00000050014	ENSMODP00000052701	ENSMODP00000050014	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	1-cysPrx_C domain-containing protein.	0.652
CAT	ENSMODP00000057895	ENSMODP00000052701	ENSMODP00000057895	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	AhpC-TSA domain-containing protein.	0.652
CAT	GLRX	ENSMODP00000052701	ENSMODP00000057569	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutaredoxin domain-containing protein.	0.537
CAT	GPX1	ENSMODP00000052701	ENSMODP00000016243	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.486
CAT	GPX2	ENSMODP00000052701	ENSMODP00000012086	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.486
CAT	GPX3	ENSMODP00000052701	ENSMODP00000042905	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.486
CAT	GPX4	ENSMODP00000052701	ENSMODP00000006783	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.576
CAT	GPX7	ENSMODP00000052701	ENSMODP00000000704	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.576
CAT	GPX8	ENSMODP00000052701	ENSMODP00000054286	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.576