107 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EPS8	Epidermal growth factor receptor pathway substrate 8. (822 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	SPIDR	DUF4502 domain-containing protein. (235 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1259 aa)
	ADCY6	AC_N domain-containing protein. (313 aa)
	PODN	Podocan. (634 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1365 aa)
	OSBPL7	Oxysterol-binding protein; Belongs to the OSBP family. (661 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (589 aa)
	EIF4EBP1	Uncharacterized protein. (273 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
	GRAMD1C	GRAM domain containing 1C. (692 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (900 aa)
	RGS19	RGS domain-containing protein. (216 aa)
	SLIT3	Slit guidance ligand 3. (1532 aa)
	SLIT2	Slit guidance ligand 2. (1542 aa)
	TUFM	Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (467 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	ENSMODP00000045019	Uncharacterized protein. (217 aa)
	ENSMODP00000044418	Uncharacterized protein. (176 aa)
	BAD	Uncharacterized protein. (212 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (337 aa)
	GOLPH3	Uncharacterized protein. (299 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (961 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (228 aa)
	GRAMD1A	GRAM domain containing 1A. (756 aa)
	BPIFB2	BPI2 domain-containing protein. (457 aa)
	LOC100017283	C-C motif chemokine. (91 aa)
	CCL19	C-C motif chemokine. (96 aa)
	GRAMD1B	GRAM domain containing 1B. (879 aa)
	UNC79	Unc-79 homolog, NALCN channel complex subunit. (2631 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (402 aa)
	TBXA2R	Thromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	XRN1	5'-3' exoribonuclease 1. (1708 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (521 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	CRHBP	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (325 aa)
	BLM	BLM RecQ like helicase. (1451 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1463 aa)
	GLRA2	Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
	PMVK	Phosphomevalonate kinase. (199 aa)
	ADAM15	ADAM metallopeptidase domain 15. (895 aa)
	GABBR1	Gamma-aminobutyric acid type B receptor subunit 1. (579 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (154 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (135 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1840 aa)
	JUP	Junction plakoglobin. (743 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
	AKAP8	A-kinase anchoring protein 8; Belongs to the AKAP95 family. (672 aa)
	FDX1	Ferredoxin 1. (184 aa)
	PTGER2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (347 aa)
	GRIN3A	Uncharacterized protein. (1153 aa)
	NR0B2	Nuclear receptor subfamily 0 group B member 2. (293 aa)
	GOT2	Aspartate aminotransferase. (429 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	BAK1	BCL2 antagonist/killer 1. (204 aa)
	SLC12A3	Solute carrier family 12 member 3. (1031 aa)
	ST6GAL1	ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (427 aa)
	MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa)
	CBL	Cbl proto-oncogene. (837 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
	DBH	Dopamine beta-hydroxylase. (614 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (737 aa)
	SLC23A2	Solute carrier family 23 member 2. (649 aa)
	SLC10A1	Solute carrier family 10 member 1. (350 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	F6ZF24_MONDO	Uncharacterized protein. (381 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (616 aa)
	GLRA1	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (458 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (505 aa)
	LARP1	La ribonucleoprotein domain family member 1. (1023 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (545 aa)
	OPRM1	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (401 aa)
	NPAS4	Neuronal PAS domain protein 4. (804 aa)
	CCL21	C-C motif chemokine ligand 21. (138 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (970 aa)
	TP53INP1	Uncharacterized protein. (220 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (657 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (645 aa)
	CLDN7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
	MLC1	Modulator of VRAC current 1. (379 aa)
	LOC100012668	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (377 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (310 aa)
	OGG1	ENDO3c domain-containing protein. (340 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	GLRA3	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (551 aa)
	HNF1A	HNF1 homeobox A. (613 aa)
	PTCH1	Patched 1. (1521 aa)
	DMAP1	DNA methyltransferase 1 associated protein 1. (462 aa)
	F7E0E8_MONDO	BH4_AAA_HYDROXYL_2 domain-containing protein. (391 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
	LRP8	LDL receptor related protein 8. (854 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSMODP00000045924	ENSMODP00000002517	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.464
ADCY1	ADCY3	ENSMODP00000045924	ENSMODP00000019825	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.943
ADCY1	ADCY5	ENSMODP00000045924	ENSMODP00000055431	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.456
ADCY1	ADCY6	ENSMODP00000045924	ENSMODP00000058527	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.439
ADCY1	ADCY7	ENSMODP00000045924	ENSMODP00000016328	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.495
ADCY1	ADCY8	ENSMODP00000045924	ENSMODP00000001732	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY1	PTRHD1	ENSMODP00000045924	ENSMODP00000019833	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Peptidyl-tRNA hydrolase domain containing 1.	0.457
ADCY2	ADCY1	ENSMODP00000002517	ENSMODP00000045924	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.464
ADCY2	ADCY5	ENSMODP00000002517	ENSMODP00000055431	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.861
ADCY2	ADCY6	ENSMODP00000002517	ENSMODP00000058527	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.630
ADCY2	ADCY7	ENSMODP00000002517	ENSMODP00000016328	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.423
ADCY2	ADCY8	ENSMODP00000002517	ENSMODP00000001732	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.439
ADCY3	ADCY1	ENSMODP00000019825	ENSMODP00000045924	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.943
ADCY3	ADCY8	ENSMODP00000019825	ENSMODP00000001732	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.948
ADCY5	ADCY1	ENSMODP00000055431	ENSMODP00000045924	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.456
ADCY5	ADCY2	ENSMODP00000055431	ENSMODP00000002517	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.861
ADCY5	ADCY7	ENSMODP00000055431	ENSMODP00000016328	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.680
ADCY5	ADCY8	ENSMODP00000055431	ENSMODP00000001732	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.478
ADCY6	ADCY1	ENSMODP00000058527	ENSMODP00000045924	AC_N domain-containing protein.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.439
ADCY6	ADCY2	ENSMODP00000058527	ENSMODP00000002517	AC_N domain-containing protein.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.630