(24 nodes) Positive regulation of purine nucleotide metabolic process network (Monodelphis domestica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	PID1	Phosphotyrosine interaction domain containing 1. (203 aa)
	GUCA1A	Uncharacterized protein. (201 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (469 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	HNF1A	HNF1 homeobox A. (613 aa)
	IGF1	Insulin like growth factor 1. (225 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (795 aa)
	GUCA2B	Uncharacterized protein. (109 aa)
	BEND3	BEN domain containing 3. (835 aa)
	GUCA1C	Guanylate cyclase activator 1C. (196 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (749 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	NOS1	Nitric oxide synthase 1. (1464 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
	INSR	Tyrosine-protein kinase receptor. (1378 aa)
	F6XW95_MONDO	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (567 aa)
	APP	Amyloid beta precursor protein. (717 aa)
	GUCA2A	Uncharacterized protein. (132 aa)
	NCS1	Neuronal calcium sensor 1. (190 aa)
	MLXIPL	Uncharacterized protein. (260 aa)
	PRXL2C	Uncharacterized protein. (263 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	PSEN1	ENSMODP00000043145	ENSMODP00000057945	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.972
GUCA1A	GUCA1C	ENSMODP00000015963	ENSMODP00000022539	Uncharacterized protein.	Guanylate cyclase activator 1C.	0.947
GUCA1C	GUCA1A	ENSMODP00000022539	ENSMODP00000015963	Guanylate cyclase activator 1C.	Uncharacterized protein.	0.947
GUCA2A	GUCA2B	ENSMODP00000047578	ENSMODP00000021621	Uncharacterized protein.	Uncharacterized protein.	0.820
GUCA2B	GUCA2A	ENSMODP00000021621	ENSMODP00000047578	Uncharacterized protein.	Uncharacterized protein.	0.820
IGF1	INSR	ENSMODP00000003043	ENSMODP00000018879	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.941
INSR	IGF1	ENSMODP00000018879	ENSMODP00000003043	Tyrosine-protein kinase receptor.	Insulin like growth factor 1.	0.941
MLXIPL	PPARA	ENSMODP00000054084	ENSMODP00000009135	Uncharacterized protein.	Peroxisome proliferator activated receptor alpha.	0.438
NOS1	NOS3	ENSMODP00000030466	ENSMODP00000033576	Nitric oxide synthase 1.	Nitric oxide synthase; Produces nitric oxide (NO).	0.901
NOS3	NOS1	ENSMODP00000033576	ENSMODP00000030466	Nitric oxide synthase; Produces nitric oxide (NO).	Nitric oxide synthase 1.	0.901
PPARA	MLXIPL	ENSMODP00000009135	ENSMODP00000054084	Peroxisome proliferator activated receptor alpha.	Uncharacterized protein.	0.438
PPARA	PPARGC1A	ENSMODP00000009135	ENSMODP00000000664	Peroxisome proliferator activated receptor alpha.	PPARG coactivator 1 alpha.	0.996
PPARGC1A	PPARA	ENSMODP00000000664	ENSMODP00000009135	PPARG coactivator 1 alpha.	Peroxisome proliferator activated receptor alpha.	0.996
PPARGC1A	PRKAA1	ENSMODP00000000664	ENSMODP00000025398	PPARG coactivator 1 alpha.	Non-specific serine/threonine protein kinase.	0.939
PRKAA1	PPARGC1A	ENSMODP00000025398	ENSMODP00000000664	Non-specific serine/threonine protein kinase.	PPARG coactivator 1 alpha.	0.939
PSEN1	APP	ENSMODP00000057945	ENSMODP00000043145	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta precursor protein.	0.972