128 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C2CD5	C2 calcium dependent domain containing 5. (1038 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (437 aa)
	SLC51B	Uncharacterized protein. (132 aa)
	ZDHHC2	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (328 aa)
	ENSMODP00000057195	SH2 domain-containing protein. (119 aa)
	DPP10	Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (720 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	GPC6	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (261 aa)
	LZTFL1	Leucine zipper transcription factor like 1. (306 aa)
	ENSMODP00000059954	Uncharacterized protein. (554 aa)
	ARHGAP44	Rho GTPase activating protein 44. (817 aa)
	ENSMODP00000057257	Uncharacterized protein. (66 aa)
	SLC7A11	Uncharacterized protein. (264 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (662 aa)
	CHP1	Calcineurin like EF-hand protein 1. (195 aa)
	PKDCC	Protein kinase domain containing, cytoplasmic. (490 aa)
	LYPD1	LY6/PLAUR domain containing 1. (140 aa)
	NKD2	NKD inhibitor of WNT signaling pathway 2. (451 aa)
	R3HDM1	R3H domain containing 1. (1128 aa)
	RHOQ	Ras homolog family member Q. (205 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1058 aa)
	EFCAB7	EF-hand calcium binding domain 7. (629 aa)
	AGR2	Uncharacterized protein. (243 aa)
	LOC100013073	Peptidase M60 domain-containing protein. (916 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (297 aa)
	VPS4A	Uncharacterized protein; Belongs to the AAA ATPase family. (587 aa)
	EPHA2	EPH receptor A2. (886 aa)
	CRIPT	CXXC repeat containing interactor of PDZ3 domain. (130 aa)
	ENSMODP00000044848	Uncharacterized protein. (85 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (357 aa)
	MYO1C	Myosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1064 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1021 aa)
	CNST	Consortin, connexin sorting protein. (721 aa)
	MMP14	Matrix metallopeptidase 14. (579 aa)
	TXNDC11	Thioredoxin domain containing 11. (949 aa)
	ZDHHC7	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (278 aa)
	GPC2	Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (571 aa)
	CNPY4	Canopy FGF signaling regulator 4. (235 aa)
	RACK1	Receptor for activated C kinase 1. (317 aa)
	TNFAIP6	TNF alpha induced protein 6. (277 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (465 aa)
	CLIP3	CAP-Gly domain containing linker protein 3. (595 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (289 aa)
	SORBS1	Sorbin and SH3 domain containing 1. (1277 aa)
	MRAP	Uncharacterized protein. (167 aa)
	SQSTM1	Sequestosome 1. (444 aa)
	MIEF2	Mab-21 domain-containing protein. (572 aa)
	EZR	Ezrin. (587 aa)
	MFF	Miff domain-containing protein. (365 aa)
	DAG1	Dystroglycan 1. (896 aa)
	ENSMODP00000049071	Uncharacterized protein. (380 aa)
	STX8	Syntaxin 8. (236 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1257 aa)
	ENSMODP00000050667	Ubiquitin-like domain-containing protein. (89 aa)
	DAB2	DAB adaptor protein 2. (772 aa)
	ENSMODP00000053891	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (138 aa)
	RANGRF	RAN guanine nucleotide release factor. (228 aa)
	RAMP3	Receptor activity modifying protein 3. (159 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (724 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1695 aa)
	VAMP8	Vesicle associated membrane protein 8. (130 aa)
	RER1	Retention in endoplasmic reticulum sorting receptor 1. (214 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (589 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1686 aa)
	BBC3	Uncharacterized protein. (318 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	MIEF1	Mitochondrial elongation factor 1. (465 aa)
	PARK2	RBR-type E3 ubiquitin transferase. (74 aa)
	K7E1M2_MONDO	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1138 aa)
	F6TU13_MONDO	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
	CACNG2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (302 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (203 aa)
	ABI3	ABI family member 3. (353 aa)
	RHOG	Ras homolog family member G. (191 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	F6TDG8_MONDO	Uncharacterized protein. (89 aa)
	LOC100617582	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1107 aa)
	PLS1	Plastin 1. (606 aa)
	ACSL3	Acyl-CoA synthetase long chain family member 3. (720 aa)
	ARHGEF16	Uncharacterized protein. (354 aa)
	WNK3	Protein kinase domain-containing protein. (626 aa)
	ZDHHC5	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (714 aa)
	LRP4	LDL receptor related protein 4. (1908 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
	GSN	Gelsolin. (776 aa)
	CIB1	Calcium and integrin binding 1. (194 aa)
	CEMIP	Cell migration inducing hyaluronidase 1. (1366 aa)
	MESD	Mesoderm development LRP chaperone. (219 aa)
	PDZK1	PDZ domain containing 1. (510 aa)
	MRAP2	Melanocortin 2 receptor accessory protein 2. (224 aa)
	GOPC	PDZ domain-containing protein. (459 aa)
	CRKL	Uncharacterized protein. (303 aa)
	HECTD1	HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
	STX7	Syntaxin 7; Belongs to the syntaxin family. (268 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (368 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (455 aa)
	KCNB1	Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (872 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (579 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
	CLN3	Battenin. (442 aa)
	TMBIM1	Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (299 aa)
	VIL1	Villin 1. (516 aa)
	GPC4	Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (560 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (486 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	GRASP	General receptor for phosphoinositides 1 associated scaffold protein. (379 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (307 aa)
	GPC1	Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (550 aa)
	STAC2	SH3 and cysteine rich domain 2. (410 aa)
	FRRS1L	Ferric chelate reductase 1 like. (264 aa)
	AR	Androgen receptor. (960 aa)
	PDCD5	Programmed cell death 5. (125 aa)
	LGALS3	Galectin. (281 aa)
	NHLRC1	NHL repeat containing E3 ubiquitin protein ligase 1. (405 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1556 aa)
	GRIPAP1	GRIP1 associated protein 1. (861 aa)
	VTI1B	Vesicle transport through interaction with t-SNAREs 1B. (231 aa)
	IQSEC2	IQ motif and Sec7 domain 2. (1228 aa)
	DMTN	Dematin actin binding protein. (406 aa)
	AKAP5	A-kinase anchoring protein 5. (454 aa)
	GPC5	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (330 aa)
	EGFR	Receptor protein-tyrosine kinase. (1213 aa)
	CSRP3	Cysteine and glycine rich protein 3. (232 aa)
	ADAM10	ADAM metallopeptidase domain 10. (748 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	KIF5B	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (966 aa)
	NLGN2	COesterase domain-containing protein. (324 aa)
	NUMB	NUMB endocytic adaptor protein. (652 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	TNF	ENSMODP00000010872	ENSMODP00000019686	ADAM metallopeptidase domain 10.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.574
AGR2	DAG1	ENSMODP00000001883	ENSMODP00000048755	Uncharacterized protein.	Dystroglycan 1.	0.483
AKAP5	DLG4	ENSMODP00000011817	ENSMODP00000007980	A-kinase anchoring protein 5.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.627
AP2M1	APPL1	ENSMODP00000054481	ENSMODP00000000103	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.489
AP2M1	CLTC	ENSMODP00000054481	ENSMODP00000041726	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.972
AP2M1	CLTCL1	ENSMODP00000054481	ENSMODP00000012659	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.972
AP2M1	DAB2	ENSMODP00000054481	ENSMODP00000051997	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	DAB adaptor protein 2.	0.628
AP2M1	EGFR	ENSMODP00000054481	ENSMODP00000011264	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Receptor protein-tyrosine kinase.	0.747
AP2M1	ENSMODP00000057257	ENSMODP00000054481	ENSMODP00000057257	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Uncharacterized protein.	0.735
AP2M1	ERBB2	ENSMODP00000054481	ENSMODP00000050019	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Receptor protein-tyrosine kinase.	0.604
AP2M1	LDLRAP1	ENSMODP00000054481	ENSMODP00000017492	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Low density lipoprotein receptor adaptor protein 1.	0.678
AP2M1	LRP4	ENSMODP00000054481	ENSMODP00000024825	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	LDL receptor related protein 4.	0.481
AP2M1	VAMP8	ENSMODP00000054481	ENSMODP00000043081	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Vesicle associated membrane protein 8.	0.498
APPL1	AP2M1	ENSMODP00000000103	ENSMODP00000054481	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.489
APPL1	ARF6	ENSMODP00000000103	ENSMODP00000032219	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.516
APPL1	CLTC	ENSMODP00000000103	ENSMODP00000041726	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.618
APPL1	CLTCL1	ENSMODP00000000103	ENSMODP00000012659	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.618
APPL1	DAB2	ENSMODP00000000103	ENSMODP00000051997	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	DAB adaptor protein 2.	0.487
APPL1	ENSMODP00000057257	ENSMODP00000000103	ENSMODP00000057257	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Uncharacterized protein.	0.618
APPL1	ENSMODP00000059954	ENSMODP00000000103	ENSMODP00000059954	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Uncharacterized protein.	0.547