(68 nodes) Regulation of reactive oxygen species metabolic process network (Monodelphis domestica)

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Your Input:
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
	F6TDG8_MONDO	Uncharacterized protein. (89 aa)
	CRP	Uncharacterized protein. (90 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (203 aa)
	F6U2S4_MONDO	Deacetylase sirtuin-type domain-containing protein. (261 aa)
	PARK2	RBR-type E3 ubiquitin transferase. (74 aa)
	THBS1	Thrombospondin 1. (1197 aa)
	TIGAR	Uncharacterized protein. (269 aa)
	PARK7	DJ-1_PfpI domain-containing protein. (189 aa)
	MPV17	Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (227 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (277 aa)
	DUOXA1	Uncharacterized protein. (371 aa)
	BCL2	BCL2 apoptosis regulator. (188 aa)
	GCH1	GTP cyclohydrolase 1. (355 aa)
	HK2	Hexokinase 2. (932 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (674 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] (315 aa)
	ARG2	Arginase. (399 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (585 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (616 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (830 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (706 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (545 aa)
	ABCD1	ATP binding cassette subfamily D member 1. (776 aa)
	PDK3	Protein-serine/threonine kinase. (415 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	TSPO	Uncharacterized protein. (275 aa)
	COQ7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (222 aa)
	ABCB7	ATP binding cassette subfamily B member 7. (724 aa)
	MPV17L	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (201 aa)
	SLC30A10	Solute carrier family 30 member 10. (475 aa)
	CYBA	Cytochrome b-245 alpha chain. (191 aa)
	AATF	Apoptosis antagonizing transcription factor. (555 aa)
	ROMO1	Reactive oxygen species modulator 1. (79 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (168 aa)
	MMP8	Matrix metallopeptidase 8. (472 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (655 aa)
	ACOD1	Aconitate decarboxylase 1. (474 aa)
	CCN6	IGFBP N-terminal domain-containing protein. (238 aa)
	XDH	Xanthine dehydrogenase. (1258 aa)
	HVCN1	Hydrogen voltage gated channel 1. (266 aa)
	COA8	Uncharacterized protein. (211 aa)
	ENSMODP00000050667	Ubiquitin-like domain-containing protein. (89 aa)
	PRCP	Prolylcarboxypeptidase. (474 aa)
	TFAP2A	Transcription factor AP-2 alpha. (444 aa)
	PINK1	Protein kinase domain-containing protein. (573 aa)
	SYK	Tyrosine-protein kinase. (588 aa)
	RNF41	RING-type domain-containing protein. (201 aa)
	ENSMODP00000057712	Uncharacterized protein. (481 aa)
	DUOXA2	Dual oxidase maturation factor 2. (323 aa)
	ABCD2	ATP binding cassette subfamily D member 2. (740 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
	PON2	Paraoxonase 2. (361 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2090 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1840 aa)
	BCO2	Beta-carotene oxygenase 2. (575 aa)
	VDAC1	Voltage dependent anion channel 1. (400 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	PARL	Rhomboid domain-containing protein. (378 aa)
	TUSC2	Uncharacterized protein. (268 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG5	BCL2	ENSMODP00000058749	ENSMODP00000006458	Autophagy protein 5; Involved in autophagic vesicle formation.	BCL2 apoptosis regulator.	0.597
ATG5	ENSMODP00000050667	ENSMODP00000058749	ENSMODP00000050667	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like domain-containing protein.	0.403
ATG5	F6TDG8_MONDO	ENSMODP00000058749	ENSMODP00000029226	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.403
ATG5	PARK2	ENSMODP00000058749	ENSMODP00000039734	Autophagy protein 5; Involved in autophagic vesicle formation.	RBR-type E3 ubiquitin transferase.	0.403
ATG5	PARL	ENSMODP00000058749	ENSMODP00000016828	Autophagy protein 5; Involved in autophagic vesicle formation.	Rhomboid domain-containing protein.	0.462
ATG5	PINK1	ENSMODP00000058749	ENSMODP00000053610	Autophagy protein 5; Involved in autophagic vesicle formation.	Protein kinase domain-containing protein.	0.658
ATG5	RIPK1	ENSMODP00000058749	ENSMODP00000010574	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.538
ATG5	VDAC1	ENSMODP00000058749	ENSMODP00000017701	Autophagy protein 5; Involved in autophagic vesicle formation.	Voltage dependent anion channel 1.	0.626
BCL2	ATG5	ENSMODP00000006458	ENSMODP00000058749	BCL2 apoptosis regulator.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.597
BCL2	BRCA1	ENSMODP00000006458	ENSMODP00000018933	BCL2 apoptosis regulator.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.422
BCL2	CDKN1A	ENSMODP00000006458	ENSMODP00000016922	BCL2 apoptosis regulator.	Cyclin dependent kinase inhibitor 1A.	0.470
BCL2	HIF1A	ENSMODP00000006458	ENSMODP00000010901	BCL2 apoptosis regulator.	Hypoxia inducible factor 1 subunit alpha.	0.620
BCL2	HK2	ENSMODP00000006458	ENSMODP00000014169	BCL2 apoptosis regulator.	Hexokinase 2.	0.447
BCL2	NFE2L2	ENSMODP00000006458	ENSMODP00000012028	BCL2 apoptosis regulator.	Nuclear factor, erythroid 2 like 2.	0.406
BCL2	PINK1	ENSMODP00000006458	ENSMODP00000053610	BCL2 apoptosis regulator.	Protein kinase domain-containing protein.	0.414
BCL2	TGFB1	ENSMODP00000006458	ENSMODP00000010737	BCL2 apoptosis regulator.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.403
BCL2	TNF	ENSMODP00000006458	ENSMODP00000019686	BCL2 apoptosis regulator.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.628
BCL2	VDAC1	ENSMODP00000006458	ENSMODP00000017701	BCL2 apoptosis regulator.	Voltage dependent anion channel 1.	0.829
BRCA1	BCL2	ENSMODP00000018933	ENSMODP00000006458	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BCL2 apoptosis regulator.	0.422
CDKN1A	BCL2	ENSMODP00000016922	ENSMODP00000006458	Cyclin dependent kinase inhibitor 1A.	BCL2 apoptosis regulator.	0.470