(44 nodes) Sarcoplasmic reticulum network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	THBS4	Thrombospondin 4. (955 aa)
	JPH1	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (659 aa)
	ENSMODP00000043447	EF-hand domain-containing protein; Belongs to the S-100 family. (72 aa)
	DHRS7C	Dehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (383 aa)
	RNF121	Ring finger protein 121. (173 aa)
	RCN1	Uncharacterized protein. (328 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (395 aa)
	PBDC1	Polysacc_synt_4 domain-containing protein. (133 aa)
	SRI	Sorcin. (234 aa)
	ASPHD2	Aspartate beta-hydroxylase domain containing 2. (369 aa)
	RYR1	Ryanodine receptor 1. (4131 aa)
	TMEM38A	Transmembrane protein 38A. (303 aa)
	CALU	Calumenin. (315 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (948 aa)
	ASPHD1	Asp_Arg_Hydrox domain-containing protein. (109 aa)
	CCDC78	DUF4472 domain-containing protein. (592 aa)
	F6WYG5_MONDO	HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (231 aa)
	S100A1	Protein S100; Belongs to the S-100 family. (94 aa)
	AKAP6	A-kinase anchoring protein 6. (2333 aa)
	FSD2	Fibronectin type III and SPRY domain containing 2. (739 aa)
	FKBP1A	Peptidylprolyl isomerase. (108 aa)
	MTMR12	Myotubularin related protein 12. (789 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	RTN2	Reticulon. (439 aa)
	F6XCF5_MONDO	Peptidylprolyl isomerase. (103 aa)
	MANF	Uncharacterized protein. (181 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (835 aa)
	ASPH	Aspartate beta-hydroxylase. (830 aa)
	DNAJC16	DnaJ heat shock protein family (Hsp40) member C16. (782 aa)
	ENSMODP00000045422	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (763 aa)
	RYR2	Ryanodine receptor 2. (4900 aa)
	STIM1	Stromal interaction molecule 1. (776 aa)
	CAMK2G	Calcium/calmodulin dependent protein kinase II gamma. (629 aa)
	ENSMODP00000048553	Uncharacterized protein. (97 aa)
	CHERP	Calcium homeostasis endoplasmic reticulum protein. (946 aa)
	RASD1	Uncharacterized protein. (278 aa)
	LOC100029733	Peptidylprolyl isomerase. (101 aa)
	RYR3	Ryanodine receptor 3. (4841 aa)
	CMYA5	Uncharacterized protein. (4209 aa)
	SRL	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (472 aa)
	ATP2A2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
	TRDN	Uncharacterized protein. (275 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (416 aa)
	FKBP1B	Peptidylprolyl isomerase. (108 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP6	RYR1	ENSMODP00000021971	ENSMODP00000016617	A-kinase anchoring protein 6.	Ryanodine receptor 1.	0.403
AKAP6	RYR2	ENSMODP00000021971	ENSMODP00000046276	A-kinase anchoring protein 6.	Ryanodine receptor 2.	0.754
ASPH	CASQ1	ENSMODP00000044854	ENSMODP00000012053	Aspartate beta-hydroxylase.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.947
ASPH	CASQ2	ENSMODP00000044854	ENSMODP00000006048	Aspartate beta-hydroxylase.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.499
ASPH	F6XCF5_MONDO	ENSMODP00000044854	ENSMODP00000034952	Aspartate beta-hydroxylase.	Peptidylprolyl isomerase.	0.423
ASPH	FKBP1A	ENSMODP00000044854	ENSMODP00000024390	Aspartate beta-hydroxylase.	Peptidylprolyl isomerase.	0.423
ASPH	FKBP1B	ENSMODP00000044854	ENSMODP00000002601	Aspartate beta-hydroxylase.	Peptidylprolyl isomerase.	0.423
ASPH	LOC100029733	ENSMODP00000044854	ENSMODP00000049139	Aspartate beta-hydroxylase.	Peptidylprolyl isomerase.	0.423
ASPH	RYR1	ENSMODP00000044854	ENSMODP00000016617	Aspartate beta-hydroxylase.	Ryanodine receptor 1.	0.637
ASPH	RYR2	ENSMODP00000044854	ENSMODP00000046276	Aspartate beta-hydroxylase.	Ryanodine receptor 2.	0.963
ASPH	RYR3	ENSMODP00000044854	ENSMODP00000049603	Aspartate beta-hydroxylase.	Ryanodine receptor 3.	0.905
ASPH	TRDN	ENSMODP00000044854	ENSMODP00000054571	Aspartate beta-hydroxylase.	Uncharacterized protein.	0.979
ATP2A1	ATP2A2	ENSMODP00000019420	ENSMODP00000054285	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.908
ATP2A1	CASQ1	ENSMODP00000019420	ENSMODP00000012053	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.402
ATP2A1	CASQ2	ENSMODP00000019420	ENSMODP00000006048	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.402
ATP2A1	ENSMODP00000045422	ENSMODP00000019420	ENSMODP00000045422	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.904
ATP2A1	PLN	ENSMODP00000019420	ENSMODP00000029517	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.988
ATP2A1	RYR1	ENSMODP00000019420	ENSMODP00000016617	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 1.	0.742
ATP2A1	SRL	ENSMODP00000019420	ENSMODP00000053021	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.607
ATP2A1	TRDN	ENSMODP00000019420	ENSMODP00000054571	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Uncharacterized protein.	0.468