(74 nodes) Tyrosine-protein kinase, catalytic domain network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DDR1	Discoidin domain receptor tyrosine kinase 1. (911 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1387 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	ALK	Tyrosine-protein kinase receptor. (548 aa)
	JAK2	Tyrosine-protein kinase. (1130 aa)
	INSR	Tyrosine-protein kinase receptor. (1378 aa)
	MST1R	Protein kinase domain-containing protein. (291 aa)
	BLK	Tyrosine-protein kinase. (501 aa)
	BTK	Tyrosine-protein kinase. (655 aa)
	TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
	FGFR1	Fibroblast growth factor receptor. (809 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (959 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
	EGFR	Receptor protein-tyrosine kinase. (1213 aa)
	FGFR4	Fibroblast growth factor receptor. (849 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
	NTRK2	Tyrosine-protein kinase receptor. (750 aa)
	NTRK3	Tyrosine-protein kinase receptor. (850 aa)
	TXK	Tyrosine-protein kinase. (525 aa)
	TEC	Tyrosine-protein kinase. (648 aa)
	FGFR2	Fibroblast growth factor receptor. (839 aa)
	ITK	Tyrosine-protein kinase. (620 aa)
	ABL2	Tyrosine-protein kinase. (1169 aa)
	TYK2	Tyrosine-protein kinase. (1193 aa)
	EPHB4	EPH receptor B4. (918 aa)
	TEK	TEK receptor tyrosine kinase. (1124 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	EPHA2	EPH receptor A2. (886 aa)
	EPHA1	EPH receptor A1. (980 aa)
	JAK1	Protein kinase domain-containing protein. (199 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (879 aa)
	MATK	Tyrosine-protein kinase. (470 aa)
	SRC	Tyrosine-protein kinase. (550 aa)
	LTK	Tyrosine-protein kinase receptor. (952 aa)
	TYRO3	TYRO3 protein tyrosine kinase. (820 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
	EPHA5	EPH receptor A5. (1050 aa)
	EPHB1	EPH receptor B1. (545 aa)
	LOC100017469	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1570 aa)
	EPHA4	EPH receptor A4. (986 aa)
	AXL	AXL receptor tyrosine kinase. (886 aa)
	BMX	Tyrosine-protein kinase. (682 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1259 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (973 aa)
	LYN	Tyrosine-protein kinase. (516 aa)
	SYK	Tyrosine-protein kinase. (588 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (888 aa)
	FGFR3	Fibroblast growth factor receptor. (729 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1257 aa)
	TNK2	Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1121 aa)
	FYN	Tyrosine-protein kinase. (600 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
	YES1	Tyrosine-protein kinase. (541 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	INSRR	Tyrosine-protein kinase receptor. (1307 aa)
	FER	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (765 aa)
	EPHA7	EPH receptor A7. (998 aa)
	HCK	Tyrosine-protein kinase. (538 aa)
	FES	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
	FRK	Tyrosine-protein kinase. (517 aa)
	LCK	Tyrosine-protein kinase. (686 aa)
	EPHA6	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (454 aa)
	EPHA3	EPH receptor A3. (984 aa)
	SRMS	Tyrosine-protein kinase. (514 aa)
	PTK6	Tyrosine-protein kinase. (453 aa)
	NTRK1	Tyrosine-protein kinase receptor. (739 aa)
	EPHB2	EPH receptor B2. (962 aa)
	EPHA8	EPH receptor A8. (1003 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	EGFR	ENSMODP00000044640	ENSMODP00000011264	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.415
ABL1	EPHA1	ENSMODP00000044640	ENSMODP00000001779	Tyrosine-protein kinase.	EPH receptor A1.	0.915
ABL1	EPHA3	ENSMODP00000044640	ENSMODP00000021172	Tyrosine-protein kinase.	EPH receptor A3.	0.909
ABL1	EPHA4	ENSMODP00000044640	ENSMODP00000026482	Tyrosine-protein kinase.	EPH receptor A4.	0.909
ABL1	EPHA5	ENSMODP00000044640	ENSMODP00000025928	Tyrosine-protein kinase.	EPH receptor A5.	0.909
ABL1	EPHA6	ENSMODP00000044640	ENSMODP00000021214	Tyrosine-protein kinase.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.909
ABL1	EPHA7	ENSMODP00000044640	ENSMODP00000022635	Tyrosine-protein kinase.	EPH receptor A7.	0.909
ABL1	EPHA8	ENSMODP00000044640	ENSMODP00000020106	Tyrosine-protein kinase.	EPH receptor A8.	0.911
ABL1	EPHB1	ENSMODP00000044640	ENSMODP00000023093	Tyrosine-protein kinase.	EPH receptor B1.	0.912
ABL1	EPHB2	ENSMODP00000044640	ENSMODP00000020127	Tyrosine-protein kinase.	EPH receptor B2.	0.912
ABL1	EPHB4	ENSMODP00000044640	ENSMODP00000005844	Tyrosine-protein kinase.	EPH receptor B4.	0.918
ABL1	FLT3	ENSMODP00000044640	ENSMODP00000049161	Tyrosine-protein kinase.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.417
ABL1	NTRK2	ENSMODP00000044640	ENSMODP00000035172	Tyrosine-protein kinase.	Tyrosine-protein kinase receptor.	0.907
ABL1	NTRK3	ENSMODP00000044640	ENSMODP00000035165	Tyrosine-protein kinase.	Tyrosine-protein kinase receptor.	0.910
ABL2	EGFR	ENSMODP00000007549	ENSMODP00000011264	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.463
ABL2	FLT3	ENSMODP00000007549	ENSMODP00000049161	Tyrosine-protein kinase.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.417
ALK	JAK1	ENSMODP00000019385	ENSMODP00000001468	Tyrosine-protein kinase receptor.	Protein kinase domain-containing protein.	0.938
ALK	JAK2	ENSMODP00000019385	ENSMODP00000019196	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.938
AXL	ERBB2	ENSMODP00000031323	ENSMODP00000050019	AXL receptor tyrosine kinase.	Receptor protein-tyrosine kinase.	0.502
AXL	JAK1	ENSMODP00000031323	ENSMODP00000001468	AXL receptor tyrosine kinase.	Protein kinase domain-containing protein.	0.917