(64 nodes) Cystine-knot cytokine network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP4	Bone morphogenetic protein 4. (410 aa)
	LHB	Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (196 aa)
	NTF4	Neurotrophin 4; Belongs to the NGF-beta family. (249 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	CER1	Cerberus 1, DAN family BMP antagonist. (265 aa)
	BMP7	Bone morphogenetic protein 7. (432 aa)
	VEGFD	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
	LOC100031977	TGF_BETA_2 domain-containing protein. (436 aa)
	GDF3	Growth differentiation factor 3. (358 aa)
	BMP5	Bone morphogenetic protein 5. (455 aa)
	IL17F	Uncharacterized protein. (161 aa)
	IL17A	Interleukin 17A. (153 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
	GDNF	Glial cell derived neurotrophic factor. (183 aa)
	GPHB5	Glycoprotein hormone subunit beta 5. (130 aa)
	FSHB	Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
	BMP6	Bone morphogenetic protein 6. (534 aa)
	BMP15	TGF_BETA_2 domain-containing protein. (380 aa)
	INHBB	Inhibin subunit beta B. (374 aa)
	BMP3	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (448 aa)
	NRTN	Neurturin. (222 aa)
	GREM1	Gremlin. (184 aa)
	NDP	CTCK domain-containing protein. (133 aa)
	PDGFA	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
	GDF1	TGF_BETA_2 domain-containing protein. (387 aa)
	SOST	Sclerostin. (214 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (285 aa)
	GDF6	Growth differentiation factor 6. (505 aa)
	LOC103092471	TGF_BETA_2 domain-containing protein. (355 aa)
	CGA	Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (146 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (343 aa)
	GDF9	TGF_BETA_2 domain-containing protein. (451 aa)
	VEGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (568 aa)
	GREM2	Gremlin 2, DAN family BMP antagonist. (187 aa)
	INHA	TGF_BETA_2 domain-containing protein. (404 aa)
	PGF	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	GDF7	TGF_BETA_2 domain-containing protein. (461 aa)
	GPHA2	Uncharacterized protein. (200 aa)
	GDF2	TGF_BETA_2 domain-containing protein. (427 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	IL17D	Interleukin 17D. (210 aa)
	INHBC	Inhibin subunit beta C. (361 aa)
	LOC100025872	Left-right determination factor. (368 aa)
	F6WY30_MONDO	Uncharacterized protein. (172 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (238 aa)
	TSHB	Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (138 aa)
	AMH	TGF_BETA_2 domain-containing protein. (607 aa)
	F6SCD3_MONDO	Uncharacterized protein. (170 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	IL17C	Uncharacterized protein. (251 aa)
	BMP2	Bone morphogenetic protein 2. (436 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (351 aa)
	ARTN	TGF_BETA_2 domain-containing protein. (278 aa)
	INHBA	Inhibin subunit beta A. (426 aa)
	GDF10	Growth differentiation factor 10. (493 aa)
	GDF5	Growth differentiation factor 5. (495 aa)
	PDGFC	Platelet derived growth factor C. (345 aa)
	SOSTDC1	Sclerostin domain containing 1. (223 aa)
	PDGFD	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
	MSTN	Myostatin. (432 aa)
	BMP10	Bone morphogenetic protein 10. (422 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH	BMP15	ENSMODP00000005779	ENSMODP00000013900	TGF_BETA_2 domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.655
AMH	GDF9	ENSMODP00000005779	ENSMODP00000054989	TGF_BETA_2 domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.681
AMH	GREM1	ENSMODP00000005779	ENSMODP00000033697	TGF_BETA_2 domain-containing protein.	Gremlin.	0.661
AMH	GREM2	ENSMODP00000005779	ENSMODP00000054964	TGF_BETA_2 domain-containing protein.	Gremlin 2, DAN family BMP antagonist.	0.659
AMH	INHA	ENSMODP00000005779	ENSMODP00000051194	TGF_BETA_2 domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.540
AMH	NOG	ENSMODP00000005779	ENSMODP00000018535	TGF_BETA_2 domain-containing protein.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.926
ARTN	GDNF	ENSMODP00000003680	ENSMODP00000025432	TGF_BETA_2 domain-containing protein.	Glial cell derived neurotrophic factor.	0.639
ARTN	NRTN	ENSMODP00000003680	ENSMODP00000027120	TGF_BETA_2 domain-containing protein.	Neurturin.	0.689
BDNF	GDNF	ENSMODP00000046028	ENSMODP00000025432	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Glial cell derived neurotrophic factor.	0.761
BDNF	NOG	ENSMODP00000046028	ENSMODP00000018535	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.544
BDNF	NRTN	ENSMODP00000046028	ENSMODP00000027120	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neurturin.	0.461
BDNF	NTF3	ENSMODP00000046028	ENSMODP00000060188	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.941
BDNF	NTF4	ENSMODP00000046028	ENSMODP00000017220	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neurotrophin 4; Belongs to the NGF-beta family.	0.956
BMP10	GDF2	ENSMODP00000014647	ENSMODP00000047320	Bone morphogenetic protein 10.	TGF_BETA_2 domain-containing protein.	0.702
BMP10	LOC103092471	ENSMODP00000014647	ENSMODP00000057948	Bone morphogenetic protein 10.	TGF_BETA_2 domain-containing protein.	0.590
BMP15	AMH	ENSMODP00000013900	ENSMODP00000005779	TGF_BETA_2 domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.655
BMP15	GDF9	ENSMODP00000013900	ENSMODP00000054989	TGF_BETA_2 domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.762
BMP15	INHA	ENSMODP00000013900	ENSMODP00000051194	TGF_BETA_2 domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.640
BMP15	NOG	ENSMODP00000013900	ENSMODP00000018535	TGF_BETA_2 domain-containing protein.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.433
BMP2	BMP4	ENSMODP00000004813	ENSMODP00000016205	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.901