25 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AVEN	Apoptosis and caspase activation inhibitor. (360 aa)
	CASP3	Caspase-3-like protein 1; Belongs to the peptidase C14A family. (276 aa)
	NPVF	Uncharacterized protein. (211 aa)
	XIAP	X-linked inhibitor of apoptosis. (498 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (438 aa)
	LOC100026811	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	ENSMODP00000043154	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (585 aa)
	SEPT1	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (85 aa)
	TMEM198	Transmembrane protein 198. (551 aa)
	LOC103100274	Uncharacterized protein. (667 aa)
	LOC654275	Caspase-3-like protein 2; Belongs to the peptidase C14A family. (276 aa)
	F7E823_MONDO	Protein kinase domain-containing protein. (353 aa)
	BAK1	BCL2 antagonist/killer 1. (204 aa)
	GSDMB	Uncharacterized protein. (434 aa)
	DIABLO	Uncharacterized protein. (247 aa)
	GSDMD	Uncharacterized protein. (471 aa)
	F6VCZ1_MONDO	Uncharacterized protein; Belongs to the peptidase C14A family. (295 aa)
	APAF1	Apoptotic peptidase activating factor 1. (1279 aa)
	CYCS	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	APIP	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (242 aa)
	BAX	Uncharacterized protein. (296 aa)
	C2H17orf47	Uncharacterized protein. (543 aa)
	GSDME	Gasdermin E. (500 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	APIP	ENSMODP00000060445	ENSMODP00000050829	Apoptotic peptidase activating factor 1.	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	0.875
APAF1	AVEN	ENSMODP00000060445	ENSMODP00000002009	Apoptotic peptidase activating factor 1.	Apoptosis and caspase activation inhibitor.	0.969
APAF1	BAK1	ENSMODP00000060445	ENSMODP00000017616	Apoptotic peptidase activating factor 1.	BCL2 antagonist/killer 1.	0.574
APAF1	BAX	ENSMODP00000060445	ENSMODP00000048795	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.715
APAF1	CASP3	ENSMODP00000060445	ENSMODP00000005560	Apoptotic peptidase activating factor 1.	Caspase-3-like protein 1; Belongs to the peptidase C14A family.	0.982
APAF1	CASP9	ENSMODP00000060445	ENSMODP00000031781	Apoptotic peptidase activating factor 1.	Caspase 9; Belongs to the peptidase C14A family.	0.996
APAF1	CYCS	ENSMODP00000060445	ENSMODP00000058499	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	DIABLO	ENSMODP00000060445	ENSMODP00000015266	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.880
APAF1	F6VCZ1_MONDO	ENSMODP00000060445	ENSMODP00000012376	Apoptotic peptidase activating factor 1.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.822
APAF1	F7E823_MONDO	ENSMODP00000060445	ENSMODP00000018334	Apoptotic peptidase activating factor 1.	Protein kinase domain-containing protein.	0.418
APAF1	LOC100026811	ENSMODP00000060445	ENSMODP00000041124	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC654275	ENSMODP00000060445	ENSMODP00000046868	Apoptotic peptidase activating factor 1.	Caspase-3-like protein 2; Belongs to the peptidase C14A family.	0.978
APAF1	MAPK1	ENSMODP00000060445	ENSMODP00000022098	Apoptotic peptidase activating factor 1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.418
APAF1	MAPK3	ENSMODP00000060445	ENSMODP00000019557	Apoptotic peptidase activating factor 1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.418
APAF1	NPVF	ENSMODP00000060445	ENSMODP00000000730	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.974
APAF1	TMEM198	ENSMODP00000060445	ENSMODP00000044869	Apoptotic peptidase activating factor 1.	Transmembrane protein 198.	0.642
APAF1	XIAP	ENSMODP00000060445	ENSMODP00000018720	Apoptotic peptidase activating factor 1.	X-linked inhibitor of apoptosis.	0.861
APIP	APAF1	ENSMODP00000050829	ENSMODP00000060445	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	Apoptotic peptidase activating factor 1.	0.875
APIP	AVEN	ENSMODP00000050829	ENSMODP00000002009	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	Apoptosis and caspase activation inhibitor.	0.404
APIP	CASP9	ENSMODP00000050829	ENSMODP00000031781	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	Caspase 9; Belongs to the peptidase C14A family.	0.618