STRINGSTRING
SHD SHD NHSL1 NHSL1 ROCK2 ROCK2 HRAS HRAS ENSMODP00000059954 ENSMODP00000059954 NCKAP1L NCKAP1L PRKACB PRKACB CYFIP1 CYFIP1 PLCG1 PLCG1 F6WLE6_MONDO F6WLE6_MONDO NCF4 NCF4 F6SQP5_MONDO F6SQP5_MONDO MAPKAPK2 MAPKAPK2 NCK2 NCK2 PRKCA PRKCA CYBA CYBA EFS EFS CSDE1 CSDE1 PAK1 PAK1 BRK1 BRK1 ELMO3 ELMO3 AKT3 AKT3 NCF1 NCF1 AKT2 AKT2 RNF222 RNF222 CRK CRK PRKCD PRKCD ITGAV ITGAV ITGB3 ITGB3 CTNNB1 CTNNB1 MAPKAPK3 MAPKAPK3 HSPB1 HSPB1 MAPK13 MAPK13 AKT1 AKT1 F6T9J4_MONDO F6T9J4_MONDO JUP JUP F7GGA1_MONDO F7GGA1_MONDO CAV1 CAV1 PTK2B PTK2B PDPK1 PDPK1 SHE SHE STX7 STX7 SHF SHF WASF1 WASF1 PAK2 PAK2 NCK1 NCK1 VEGFA VEGFA PIK3R1 PIK3R1 MAPKAP1 MAPKAP1 KDR KDR LOC100015800 LOC100015800 PIK3CA PIK3CA FNDC3B FNDC3B F6PHG0_MONDO F6PHG0_MONDO CDH5 CDH5 CASS4 CASS4 ELMO2 ELMO2 PXN PXN AXL AXL CYFIP2 CYFIP2 WASF2 WASF2 CDC42 CDC42 VAV1 VAV1 F7CI75_MONDO F7CI75_MONDO FNDC3A FNDC3A NOS3 NOS3 KRAS-2 KRAS-2 TGFB1I1 TGFB1I1 ELMO1 ELMO1 SHB SHB NCKAP1 NCKAP1 NEDD9 NEDD9 LPXN LPXN PAK3 PAK3 ENSMODP00000043620 ENSMODP00000043620 BAIAP2 BAIAP2 SPHK1 SPHK1 PRKCB PRKCB ENSMODP00000045559 ENSMODP00000045559 RASA1 RASA1 MAPK14 MAPK14 HSH2D HSH2D PRR5 PRR5 NRAS NRAS PRKACA PRKACA ABI1 ABI1 ENSMODP00000049921 ENSMODP00000049921 ENSMODP00000051258 ENSMODP00000051258 PTK2 PTK2 SH2D2A SH2D2A PIK3CB PIK3CB WASF3 WASF3 MAPK12 MAPK12 VAV3 VAV3 KRAS KRAS ROCK1 ROCK1 ABI2 ABI2 CTNND1 CTNND1 ENSMODP00000058181 ENSMODP00000058181 ENSMODP00000059161 ENSMODP00000059161
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHDSrc homology 2 domain containing transforming protein D. (281 aa)
NHSL1NHS like 1. (1715 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1482 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
ENSMODP00000059954Uncharacterized protein. (554 aa)
NCKAP1LUncharacterized protein. (610 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (445 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
F6WLE6_MONDOFocal_AT domain-containing protein. (115 aa)
NCF4Neutrophil cytosolic factor 4. (340 aa)
F6SQP5_MONDOUncharacterized protein. (1162 aa)
MAPKAPK2MAPK activated protein kinase 2. (388 aa)
NCK2Cytoplasmic protein. (380 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
CYBACytochrome b-245 alpha chain. (191 aa)
EFSEmbryonal Fyn-associated substrate. (489 aa)
CSDE1Cold shock domain containing E1. (845 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
BRK1Uncharacterized protein. (106 aa)
ELMO3Engulfment and cell motility 3. (720 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NCF1Neutrophil cytosolic factor 1. (389 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
RNF222Ring finger protein 222. (218 aa)
CRKCRK proto-oncogene, adaptor protein. (297 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1058 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
CTNNB1Catenin beta 1. (781 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (395 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (256 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
F6T9J4_MONDOUncharacterized protein. (191 aa)
JUPJunction plakoglobin. (743 aa)
F7GGA1_MONDOSH2 domain-containing protein. (68 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (455 aa)
SHESrc homology 2 domain containing E. (525 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (268 aa)
SHFSrc homology 2 domain containing F. (245 aa)
WASF1WASP family member 1. (546 aa)
PAK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
NCK1Cytoplasmic protein. (419 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
LOC100015800Uncharacterized protein. (440 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FNDC3BFibronectin type III domain containing 3B. (1118 aa)
F6PHG0_MONDOUncharacterized protein. (1190 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (722 aa)
CASS4Cas scaffold protein family member 4. (830 aa)
ELMO2Engulfment and cell motility 2. (742 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (590 aa)
AXLAXL receptor tyrosine kinase. (886 aa)
CYFIP2Cytoplasmic FMR1 interacting protein 2. (1138 aa)
WASF2WASP family member 2. (497 aa)
CDC42Cell division cycle 42. (191 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
F7CI75_MONDOUncharacterized protein. (223 aa)
FNDC3AFibronectin type III domain containing 3A. (1204 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (442 aa)
ELMO1PH domain-containing protein. (144 aa)
SHBSH2 domain-containing protein. (525 aa)
NCKAP1NCK associated protein 1. (1115 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
LPXNLeupaxin. (409 aa)
PAK3Non-specific serine/threonine protein kinase. (632 aa)
ENSMODP00000043620Protein kinase domain-containing protein. (291 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
SPHK1Sphingosine kinase 1. (454 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
ENSMODP00000045559Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
RASA1RAS p21 protein activator 1. (1022 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
HSH2DUncharacterized protein. (297 aa)
PRR5Uncharacterized protein. (408 aa)
NRASGTPase NRas. (195 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
ABI1Abl interactor 1. (508 aa)
ENSMODP00000049921Uncharacterized protein. (742 aa)
ENSMODP00000051258CRIB domain-containing protein. (122 aa)
PTK2Uncharacterized protein. (161 aa)
SH2D2ASH2 domain-containing protein. (427 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
WASF3WASP family member 3. (503 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
KRASGTPase KRas. (189 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1322 aa)
ABI2Abl interactor 2. (566 aa)
CTNND1Catenin delta 1. (965 aa)
ENSMODP00000058181Uncharacterized protein. (134 aa)
ENSMODP00000059161FERM domain-containing protein. (121 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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