STRINGSTRING
SRC SRC PLCG1 PLCG1 PDGFD PDGFD JAK1 JAK1 IL6 IL6 PDGFC PDGFC PIK3R3 PIK3R3 IGF1 IGF1 SHC4 SHC4 GAS6 GAS6 RPS6 RPS6 PRKCA PRKCA EIF4E1B EIF4E1B RAF1 RAF1 AKT3 AKT3 RPS6KB1 RPS6KB1 GRB2 GRB2 RPS6KB2 RPS6KB2 AKT2 AKT2 FGFR2 FGFR2 SOS1 SOS1 EGFR EGFR PDGFB PDGFB MAP2K1 MAP2K1 PDGFRB PDGFRB TGFA TGFA SOS2 SOS2 SHC3 SHC3 AKT1 AKT1 PLCG2 PLCG2 JAK2 JAK2 MAPK3 MAPK3 MET MET F6VMH3_MONDO F6VMH3_MONDO HGF HGF SHC1 SHC1 MAPK1 MAPK1 FOXO3 FOXO3 FGF2 FGF2 VEGFA VEGFA F7FNN8_MONDO F7FNN8_MONDO BCL2L1 BCL2L1 PIK3R1 PIK3R1 PDGFRA PDGFRA KDR KDR EIF4E EIF4E PIK3CA PIK3CA EIF4E2 EIF4E2 AXL AXL NRG2 NRG2 IL6R IL6R BRAF BRAF EGF EGF KRAS-2 KRAS-2 BAD BAD PRKCB PRKCB PDGFA PDGFA NRAS NRAS BAX BAX ERBB3 ERBB3 ARAF ARAF ERBB2 ERBB2 STAT3 STAT3 EIF4EBP1 EIF4EBP1 PIK3CB PIK3CB SIRT6 SIRT6 NRG1 NRG1 NF1 NF1 GAB1 GAB1 MTOR MTOR IGF1R IGF1R GSK3B GSK3B HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (550 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
JAK1Protein kinase domain-containing protein. (199 aa)
IL6Uncharacterized protein. (220 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
IGF1Insulin like growth factor 1. (225 aa)
SHC4SHC adaptor protein 4. (678 aa)
GAS6Growth arrest specific 6. (677 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
EIF4E1BUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (476 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet derived growth factor receptor beta. (1061 aa)
TGFATransforming growth factor alpha. (159 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
SHC3SHC adaptor protein 3. (602 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1387 aa)
F6VMH3_MONDOUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (169 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
SHC1SHC adaptor protein 1. (577 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
FOXO3Fork-head domain-containing protein. (697 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
BCL2L1BCL2 like 1. (227 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (235 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (248 aa)
AXLAXL receptor tyrosine kinase. (886 aa)
NRG2Neuregulin 2. (630 aa)
IL6RInterleukin-6 receptor alpha. (467 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
EGFEpidermal growth factor. (1143 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
BADUncharacterized protein. (212 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
NRASGTPase NRas. (195 aa)
BAXUncharacterized protein. (296 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
ARAFUncharacterized protein. (198 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
STAT3Signal transducer and activator of transcription. (805 aa)
EIF4EBP1Uncharacterized protein. (273 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
SIRT6Uncharacterized protein. (547 aa)
NRG1Neuregulin 1. (703 aa)
NF1Neurofibromin 1. (2781 aa)
GAB1GRB2 associated binding protein 1. (743 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.