STRINGSTRING
LOC100010741 LOC100010741 BIRC2 BIRC2 MSH2 MSH2 MSH6 MSH6 MGST3 MGST3 PIK3R3 PIK3R3 XPA XPA ABCC2 ABCC2 ATP7A ATP7A CASP3 CASP3 AKT3 AKT3 GSTT2B GSTT2B F6RC85_MONDO F6RC85_MONDO MDM2 MDM2 AKT2 AKT2 LOC100022164 LOC100022164 TOP2A TOP2A MLH1 MLH1 CDKN1A CDKN1A AKT1 AKT1 BAK1 BAK1 TOP2B TOP2B XIAP XIAP BRCA1 BRCA1 CASP8 CASP8 MAPK3 MAPK3 MAP3K5 MAP3K5 MAPK1 MAPK1 MGST1 MGST1 REV3L REV3L LOC100014035 LOC100014035 LOC100017091 LOC100017091 POLH POLH BCL2L1 BCL2L1 PIK3R1 PIK3R1 MSH3 MSH3 PIK3CA PIK3CA ATP7B ATP7B CASP18 CASP18 LOC100026811 LOC100026811 BBC3 BBC3 CDKN2A CDKN2A BIRC5 BIRC5 SLC31A1 SLC31A1 BAD BAD GSTM3 GSTM3 LOC654275 LOC654275 BAX BAX ERBB2 ERBB2 PIK3CB PIK3CB GSTP1 GSTP1 LOC100022188 LOC100022188 ERCC1 ERCC1 CYCS CYCS FADD FADD ATM ATM APAF1 APAF1 MGST2 MGST2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100010741CARD domain-containing protein. (585 aa)
BIRC2Uncharacterized protein. (383 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (969 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1584 aa)
MGST3Microsomal glutathione S-transferase 3. (154 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
XPAXPA, DNA damage recognition and repair factor. (275 aa)
ABCC2ATP binding cassette subfamily C member 2. (1554 aa)
ATP7AATPase copper transporting alpha. (1463 aa)
CASP3Caspase-3-like protein 1; Belongs to the peptidase C14A family. (276 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GSTT2BUncharacterized protein; Belongs to the GST superfamily. (242 aa)
F6RC85_MONDOGST N-terminal domain-containing protein. (88 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (484 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
LOC100022164Uncharacterized protein; Belongs to the GST superfamily. (242 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1557 aa)
MLH1MutL homolog 1. (731 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAK1BCL2 antagonist/killer 1. (204 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1631 aa)
XIAPX-linked inhibitor of apoptosis. (498 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1840 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (472 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1390 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3177 aa)
LOC100014035Uncharacterized protein; Belongs to the GST superfamily. (220 aa)
LOC100017091Uncharacterized protein. (221 aa)
POLHDNA polymerase eta. (704 aa)
BCL2L1BCL2 like 1. (227 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1110 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ATP7BATPase copper transporting beta. (1479 aa)
CASP18Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
LOC100026811Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
BBC3Uncharacterized protein. (318 aa)
CDKN2ATumor suppressor ARF; Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcr [...] (185 aa)
BIRC5Uncharacterized protein. (127 aa)
SLC31A1Solute carrier family 31 member 1. (189 aa)
BADUncharacterized protein. (212 aa)
GSTM3Glutathione S-transferase. (223 aa)
LOC654275Caspase-3-like protein 2; Belongs to the peptidase C14A family. (276 aa)
BAXUncharacterized protein. (296 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (177 aa)
LOC100022188Uncharacterized protein; Belongs to the GST superfamily. (252 aa)
ERCC1Uncharacterized protein. (436 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
FADDUncharacterized protein. (193 aa)
ATMTAN domain-containing protein. (112 aa)
APAF1Apoptotic peptidase activating factor 1. (1279 aa)
MGST2Microsomal glutathione S-transferase 2. (164 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.