STRINGSTRING
SRC SRC PAK6 PAK6 PLCG1 PLCG1 NRG3 NRG3 MYC MYC CBLB CBLB PIK3R3 PIK3R3 NCK2 NCK2 SHC4 SHC4 JUN JUN PRKCA PRKCA PAK5 PAK5 PAK1 PAK1 RAF1 RAF1 AKT3 AKT3 RPS6KB1 RPS6KB1 GRB2 GRB2 RPS6KB2 RPS6KB2 AKT2 AKT2 SOS1 SOS1 EGFR EGFR MAP2K1 MAP2K1 TGFA TGFA HBEGF HBEGF SOS2 SOS2 CBL CBL SHC3 SHC3 CDKN1A CDKN1A AKT1 AKT1 LOC100011470 LOC100011470 LOC100012174 LOC100012174 MAP2K7 MAP2K7 PLCG2 PLCG2 MAPK3 MAPK3 ERBB4 ERBB4 CAMK2B CAMK2B SHC1 SHC1 CRKL CRKL MAPK1 MAPK1 CDKN1B CDKN1B PAK2 PAK2 NCK1 NCK1 F7FNN8_MONDO F7FNN8_MONDO EREG EREG AREG AREG PIK3R1 PIK3R1 MAPK10 MAPK10 PIK3CA PIK3CA MAPK9 MAPK9 NRG2 NRG2 BRAF BRAF EGF EGF KRAS-2 KRAS-2 NRG4 NRG4 BAD BAD ABL1 ABL1 PRKCB PRKCB NRAS NRAS ERBB3 ERBB3 ARAF ARAF ERBB2 ERBB2 PTK2 PTK2 EIF4EBP1 EIF4EBP1 PIK3CB PIK3CB SIRT6 SIRT6 NRG1 NRG1 PAK4 PAK4 GAB1 GAB1 MTOR MTOR CAMK2D CAMK2D GSK3B GSK3B HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (550 aa)
PAK6P21 (RAC1) activated kinase 6. (592 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
NRG3Uncharacterized protein. (344 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
CBLBCbl proto-oncogene B. (983 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
NCK2Cytoplasmic protein. (380 aa)
SHC4SHC adaptor protein 4. (678 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (344 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
PAK5Non-specific serine/threonine protein kinase. (812 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (476 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TGFATransforming growth factor alpha. (159 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
CBLCbl proto-oncogene. (837 aa)
SHC3SHC adaptor protein 3. (602 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC100011470Signal transducer and activator of transcription. (839 aa)
LOC100012174Signal transducer and activator of transcription. (782 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (546 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (671 aa)
SHC1SHC adaptor protein 1. (577 aa)
CRKLUncharacterized protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
CDKN1BP27 protein. (199 aa)
PAK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
NCK1Cytoplasmic protein. (419 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
EREGEpiregulin. (179 aa)
AREGAmphiregulin. (237 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NRG2Neuregulin 2. (630 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
EGFEpidermal growth factor. (1143 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
NRG4Neuregulin 4. (116 aa)
BADUncharacterized protein. (212 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
NRASGTPase NRas. (195 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
ARAFUncharacterized protein. (198 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
PTK2Uncharacterized protein. (161 aa)
EIF4EBP1Uncharacterized protein. (273 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
SIRT6Uncharacterized protein. (547 aa)
NRG1Neuregulin 1. (703 aa)
PAK4Non-specific serine/threonine protein kinase. (616 aa)
GAB1GRB2 associated binding protein 1. (743 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
CAMK2DProtein kinase domain-containing protein. (145 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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