STRINGSTRING
GNA12 GNA12 PLCB2 PLCB2 TRPC6 TRPC6 EDNRA EDNRA CREB3L3 CREB3L3 VDAC2 VDAC2 PRKCE PRKCE PPIF PPIF ATP2B4 ATP2B4 ADCY8 ADCY8 EDNRB EDNRB GUCY1A1 GUCY1A1 GNAI3 GNAI3 ADCY2 ADCY2 LOC100010487 LOC100010487 NPPC NPPC CALM1 CALM1 ATP1B1 ATP1B1 NFATC4 NFATC4 ADCY4 ADCY4 ADRA2C ADRA2C MEF2B MEF2B GNA13 GNA13 PLCB1 PLCB1 ITPR1 ITPR1 F6Y3Q3_MONDO F6Y3Q3_MONDO SLC25A4 SLC25A4 ADRB2 ADRB2 RAF1 RAF1 AKT3 AKT3 NPR2 NPR2 ATP1B2 ATP1B2 CREB3 CREB3 PDE3B PDE3B AKT2 AKT2 ADRA1B ADRA1B ADRA2B ADRA2B ATP2B3 ATP2B3 PIK3R5 PIK3R5 SLC8A1 SLC8A1 ATF4 ATF4 PPP3CC PPP3CC CALML4 CALML4 ATF2 ATF2 MAP2K1 MAP2K1 ADRB1 ADRB1 LOC100033060 LOC100033060 ADRA2A ADRA2A F7FK82_MONDO F7FK82_MONDO ADRB3 ADRB3 NPPA NPPA OPRD1 OPRD1 GATA4 GATA4 RGS2 RGS2 SLC25A31 SLC25A31 MYLK3 MYLK3 GNAQ GNAQ ADCY7 ADCY7 AKT1 AKT1 CREB3L2 CREB3L2 VDAC1 VDAC1 ATF6B ATF6B INSR INSR CREB5 CREB5 ADRA1D ADRA1D ATP2A1 ATP2A1 PPP1CB PPP1CB MAPK3 MAPK3 KNG1 KNG1 ADCY3 ADCY3 ADCY9 ADCY9 PIK3CG PIK3CG PRKG1 PRKG1 ITPR2 ITPR2 ADRA1A ADRA1A GNAI1 GNAI1 CREB3L4 CREB3L4 NPR1 NPR1 MAPK1 MAPK1 PDE3A PDE3A MYLK MYLK SRF SRF GNA11 GNA11 KCNMB4 KCNMB4 PPP1R12A PPP1R12A PPP3CA PPP3CA PRKG2 PRKG2 KCNMB3 KCNMB3 KCNMB2 KCNMB2 F7D7P9_MONDO F7D7P9_MONDO PLN PLN SLC8A2 SLC8A2 NOS3 NOS3 IRS1 IRS1 CALML3 CALML3 AGTR1 AGTR1 CACNA1S CACNA1S LOC100018337 LOC100018337 IRS2 IRS2 FXYD2 FXYD2 KCNMA1 KCNMA1 GNAI2 GNAI2 ADORA3 ADORA3 NFATC3 NFATC3 MYL9 MYL9 BAD BAD CREB3L1 CREB3L1 PPP3CB PPP3CB ENSMODP00000045422 ENSMODP00000045422 PDE5A PDE5A ADCY1 ADCY1 PPP1CC PPP1CC MYLK4 MYLK4 NFATC1 NFATC1 PLCB4 PLCB4 KCNMB1 KCNMB1 GUCY1B1 GUCY1B1 NFATC2 NFATC2 CACNA1C CACNA1C ATP2B1 ATP2B1 KCNU1 KCNU1 KCNJ8 KCNJ8 SLC8A3 SLC8A3 ITPR3 ITPR3 ATP2A2 ATP2A2 ROCK1 ROCK1 SIRT6 SIRT6 BDKRB2 BDKRB2 VDAC3 VDAC3 RHOA RHOA GTF2I GTF2I PDE2A PDE2A CREB1 CREB1 MYH6 MYH6 ROCK2 ROCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNA12G protein subunit alpha 12. (380 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (903 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (508 aa)
VDAC2Voltage dependent anion channel 2. (283 aa)
PRKCEProtein kinase domain-containing protein. (212 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1058 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (434 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (688 aa)
GNAI3G protein subunit alpha i3. (399 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
LOC100010487Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
NPPCNatriuretic peptide C. (128 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (304 aa)
NFATC4Nuclear factor of activated T cells 4. (902 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
ADRA2CAdrenoceptor alpha 2C. (469 aa)
MEF2BMyocyte enhancer factor 2B. (398 aa)
GNA13G protein subunit alpha 13. (377 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
F6Y3Q3_MONDOGuanylate cyclase. (847 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
ADRB2Adrenoceptor beta 2. (393 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NPR2Guanylate cyclase. (1047 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
CREB3BZIP domain-containing protein. (370 aa)
PDE3BPhosphodiesterase. (1156 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
ADRA1BAdrenoceptor alpha 1B. (505 aa)
ADRA2BAdrenoceptor alpha 2B. (441 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1073 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (873 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (627 aa)
ATF4Activating transcription factor 4. (346 aa)
PPP3CCSerine/threonine-protein phosphatase. (517 aa)
CALML4Calmodulin like 4. (156 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADRB1Adrenoceptor beta 1. (505 aa)
LOC100033060Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1099 aa)
ADRA2AAdrenoceptor alpha 2A. (438 aa)
F7FK82_MONDOGuanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (667 aa)
ADRB3G_PROTEIN_RECEP_F1_2 domain-containing protein. (518 aa)
NPPANatriuretic peptide A. (160 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GATA4GATA binding protein 4. (451 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (314 aa)
MYLK3Myosin light chain kinase 3. (846 aa)
GNAQG protein subunit alpha q. (359 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (518 aa)
VDAC1Voltage dependent anion channel 1. (400 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (504 aa)
ADRA1DAdrenoceptor alpha 1D. (555 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (948 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
KNG1Uncharacterized protein. (618 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1099 aa)
PRKG1Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (455 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
ADRA1AAdrenoceptor alpha 1A. (465 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (360 aa)
NPR1Guanylate cyclase. (904 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
PDE3APhosphodiesterase. (1169 aa)
MYLKMyosin light chain kinase. (1948 aa)
SRFSerum response factor. (490 aa)
GNA11G protein subunit alpha 11. (359 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (878 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PRKG2cGMP-dependent protein kinase. (759 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (284 aa)
KCNMB2Uncharacterized protein. (228 aa)
F7D7P9_MONDOUncharacterized protein; Belongs to the calmodulin family. (65 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
SLC8A2Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (431 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
LOC100018337Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
IRS2Insulin receptor substrate 2. (1384 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (123 aa)
KCNMA1BK_channel_a domain-containing protein. (189 aa)
GNAI2G protein subunit alpha i2. (315 aa)
ADORA3Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (319 aa)
NFATC3Nuclear factor of activated T cells 3. (1079 aa)
MYL9Uncharacterized protein. (172 aa)
BADUncharacterized protein. (212 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (535 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
ENSMODP00000045422Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (763 aa)
PDE5APhosphodiesterase. (902 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
MYLK4Protein kinase domain-containing protein. (690 aa)
NFATC1Nuclear factor of activated T cells 1. (950 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
KCNMB1Uncharacterized protein. (203 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (626 aa)
NFATC2Nuclear factor of activated T cells 2. (927 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2123 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1201 aa)
KCNJ8Uncharacterized protein. (424 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1322 aa)
SIRT6Uncharacterized protein. (547 aa)
BDKRB2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (381 aa)
VDAC3Uncharacterized protein. (284 aa)
RHOAUncharacterized protein. (193 aa)
GTF2IGeneral transcription factor IIi. (1035 aa)
PDE2APhosphodiesterase. (1013 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1943 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1482 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
Server load: low (16%) [HD]