STRINGSTRING
SETD7 SETD7 GADD45A GADD45A GADD45G GADD45G SGK2 SGK2 IL6 IL6 FBXO32 FBXO32 IL10 IL10 PIK3R3 PIK3R3 IGF1 IGF1 PRKAA2 PRKAA2 HOMER3 HOMER3 TGFB2 TGFB2 PRKAG2 PRKAG2 TGFB3 TGFB3 CDKN2D CDKN2D RAF1 RAF1 AKT3 AKT3 SLC2A4 SLC2A4 PLK1 PLK1 MDM2 MDM2 GRB2 GRB2 SOD2 SOD2 AKT2 AKT2 SGK3 SGK3 TGFB1 TGFB1 SOS1 SOS1 CCNB2 CCNB2 EGFR EGFR MAP2K1 MAP2K1 IKBKB IKBKB FOXO1 FOXO1 CHUK CHUK CCNB3 CCNB3 SOS2 SOS2 PLK4 PLK4 TGFBR1 TGFBR1 RBL2 RBL2 CDKN1A CDKN1A PRMT1 PRMT1 MAPK13 MAPK13 AKT1 AKT1 INSR INSR TGFBR2 TGFBR2 PRKAB1 PRKAB1 PRKAG3 PRKAG3 MAPK3 MAPK3 PRKAG1 PRKAG1 CREBBP CREBBP PCK1 PCK1 GRM1 GRM1 SIRT1 SIRT1 FOXO6 FOXO6 FOXG1 FOXG1 MAPK1 MAPK1 FOXO3 FOXO3 CDKN1B CDKN1B CCND2 CCND2 CSNK1E CSNK1E F7FNN8_MONDO F7FNN8_MONDO S1PR4 S1PR4 HOMER2 HOMER2 BNIP3 BNIP3 PIK3R1 PIK3R1 CCNB1 CCNB1 HOMER1 HOMER1 PRKAA1 PRKAA1 SKP2 SKP2 IL7R IL7R MAPK10 MAPK10 PIK3CA PIK3CA S1PR1 S1PR1 MAPK9 MAPK9 G6PC3 G6PC3 BRAF BRAF RAG2 RAG2 RAG1 RAG1 IRS1 IRS1 F6VUA1_MONDO F6VUA1_MONDO IRS2 IRS2 EGF EGF KRAS-2 KRAS-2 EP300 EP300 STK11 STK11 G6PC G6PC KLF2 KLF2 CDKN2B CDKN2B MAPK14 MAPK14 SMAD3 SMAD3 FOXO4 FOXO4 NRAS NRAS STK4 STK4 ARAF ARAF CCND1 CCND1 PRKAB2 PRKAB2 PCK2 PCK2 NLK NLK STAT3 STAT3 CAT CAT SGK1 SGK1 PIK3CB PIK3CB MAPK12 MAPK12 GABARAPL2 GABARAPL2 TNFSF10 TNFSF10 CCNG2 CCNG2 SIRT6 SIRT6 IGF1R IGF1R FBXO25 FBXO25 ATM ATM HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SETD7SET domain containing 7, histone lysine methyltransferase. (227 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (168 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (362 aa)
IL6Uncharacterized protein. (220 aa)
FBXO32F-box protein 32. (355 aa)
IL10Interleukin 10. (173 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
IGF1Insulin like growth factor 1. (225 aa)
PRKAA2Non-specific serine/threonine protein kinase. (551 aa)
HOMER3WH1 domain-containing protein. (358 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (580 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (167 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PLK1Serine/threonine-protein kinase PLK. (614 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (484 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
FOXO1Forkhead box O1. (670 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CCNB3Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (403 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
PLK4Polo like kinase 4. (964 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
RBL2RB transcriptional corepressor like 2. (1145 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (390 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
PRKAB1AMPKBI domain-containing protein. (273 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (471 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (310 aa)
CREBBPCREB binding protein. (2456 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
GRM1G_PROTEIN_RECEP_F3_4 domain-containing protein. (798 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (713 aa)
FOXO6Forkhead box O6. (622 aa)
FOXG1Forkhead box G1. (492 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
FOXO3Fork-head domain-containing protein. (697 aa)
CDKN1BP27 protein. (199 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (290 aa)
CSNK1EUncharacterized protein. (210 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
S1PR4Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. (375 aa)
HOMER2Homer scaffold protein 2. (353 aa)
BNIP3BCL2 interacting protein 3. (195 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (414 aa)
HOMER1Homer scaffold protein 1. (410 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
SKP2S-phase kinase associated protein 2. (422 aa)
IL7RFibronectin type-III domain-containing protein. (456 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
RAG2Recombination activating 2. (527 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1047 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
F6VUA1_MONDOUncharacterized protein. (139 aa)
IRS2Insulin receptor substrate 2. (1384 aa)
EGFEpidermal growth factor. (1143 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
EP300E1A binding protein p300. (2454 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (414 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
KLF2Uncharacterized protein. (77 aa)
CDKN2BANK_REP_REGION domain-containing protein. (138 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
FOXO4FOXO-TAD domain-containing protein. (350 aa)
NRASGTPase NRas. (195 aa)
STK4Serine/threonine kinase 4. (496 aa)
ARAFUncharacterized protein. (198 aa)
CCND1Uncharacterized protein. (67 aa)
PRKAB2AMPKBI domain-containing protein. (106 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (553 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (529 aa)
STAT3Signal transducer and activator of transcription. (805 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (529 aa)
SGK1Non-specific serine/threonine protein kinase. (524 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
GABARAPL2Uncharacterized protein. (289 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (301 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (434 aa)
SIRT6Uncharacterized protein. (547 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
FBXO25F-box protein 25. (419 aa)
ATMTAN domain-containing protein. (112 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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