61 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SESN3	Sestrin 3. (484 aa)
	STEAP3	STEAP3 metalloreductase. (535 aa)
	ADGRB1	Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1617 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (168 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (488 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (334 aa)
	IGF1	Insulin like growth factor 1. (225 aa)
	EI24	EI24 autophagy associated transmembrane protein. (340 aa)
	CASP3	Caspase-3-like protein 1; Belongs to the peptidase C14A family. (276 aa)
	SERPINB5	Serpin family B member 5; Belongs to the serpin family. (375 aa)
	COP1	COP1 E3 ubiquitin ligase. (741 aa)
	RRM2B	Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa)
	CCNE2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (484 aa)
	GTSE1	GTSE1_N domain-containing protein. (692 aa)
	CHEK2	Checkpoint kinase 2. (531 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (398 aa)
	LOC103100524	Uncharacterized protein. (408 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (283 aa)
	SESN2	Sestrin 2. (478 aa)
	SIAH1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	SIVA1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (178 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (601 aa)
	SHISA5	Uncharacterized protein. (148 aa)
	PIDD1	Uncharacterized protein. (272 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (472 aa)
	TSC2	TSC complex subunit 2. (1830 aa)
	CDK1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	PERP	P53 apoptosis effector related to PMP22. (194 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (290 aa)
	BCL2L1	BCL2 like 1. (227 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (414 aa)
	DDB2	WD_REPEATS_REGION domain-containing protein. (480 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (256 aa)
	CASP18	Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
	LOC100026811	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	BBC3	Uncharacterized protein. (318 aa)
	CDKN2A	Tumor suppressor ARF; Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcr [...] (185 aa)
	CCNG1	Cyclin G1; Belongs to the cyclin family. (295 aa)
	GORAB	Golgin, RAB6 interacting. (339 aa)
	THBS1	Thrombospondin 1. (1197 aa)
	ZMAT3	Zinc finger matrin-type 3. (290 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (413 aa)
	LOC654275	Caspase-3-like protein 2; Belongs to the peptidase C14A family. (276 aa)
	BAX	Uncharacterized protein. (296 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (390 aa)
	RRM2	Uncharacterized protein. (341 aa)
	CCND1	Uncharacterized protein. (67 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (300 aa)
	ATR	Uncharacterized protein. (159 aa)
	ENSMODP00000053344	WD_REPEATS_REGION domain-containing protein. (474 aa)
	RPRM	Reprimo, TP53 dependent G2 arrest mediator homolog. (109 aa)
	CD82	Tetraspanin. (265 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (434 aa)
	CCNE1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (732 aa)
	CYCS	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	ATM	TAN domain-containing protein. (112 aa)
	APAF1	Apoptotic peptidase activating factor 1. (1279 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	ATM	ENSMODP00000060445	ENSMODP00000059879	Apoptotic peptidase activating factor 1.	TAN domain-containing protein.	0.475
APAF1	BAX	ENSMODP00000060445	ENSMODP00000048795	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.715
APAF1	BCL2L1	ENSMODP00000060445	ENSMODP00000024313	Apoptotic peptidase activating factor 1.	BCL2 like 1.	0.818
APAF1	CASP18	ENSMODP00000060445	ENSMODP00000040167	Apoptotic peptidase activating factor 1.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.788
APAF1	CASP3	ENSMODP00000060445	ENSMODP00000005560	Apoptotic peptidase activating factor 1.	Caspase-3-like protein 1; Belongs to the peptidase C14A family.	0.982
APAF1	CASP8	ENSMODP00000060445	ENSMODP00000018969	Apoptotic peptidase activating factor 1.	Caspase 8; Belongs to the peptidase C14A family.	0.778
APAF1	CYCS	ENSMODP00000060445	ENSMODP00000058499	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC100026811	ENSMODP00000060445	ENSMODP00000041124	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC654275	ENSMODP00000060445	ENSMODP00000046868	Apoptotic peptidase activating factor 1.	Caspase-3-like protein 2; Belongs to the peptidase C14A family.	0.978
APAF1	PIDD1	ENSMODP00000060445	ENSMODP00000018737	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.503
ATM	APAF1	ENSMODP00000059879	ENSMODP00000060445	TAN domain-containing protein.	Apoptotic peptidase activating factor 1.	0.475
ATM	ATR	ENSMODP00000059879	ENSMODP00000052412	TAN domain-containing protein.	Uncharacterized protein.	0.999
ATM	CASP18	ENSMODP00000059879	ENSMODP00000040167	TAN domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.915
ATM	CASP8	ENSMODP00000059879	ENSMODP00000018969	TAN domain-containing protein.	Caspase 8; Belongs to the peptidase C14A family.	0.915
ATM	CDK1	ENSMODP00000059879	ENSMODP00000021329	TAN domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.569
ATM	CDK6	ENSMODP00000059879	ENSMODP00000048851	TAN domain-containing protein.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.569
ATM	CDKN2A	ENSMODP00000059879	ENSMODP00000041371	TAN domain-containing protein.	Tumor suppressor ARF; Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcr [...]	0.429
ATM	CHEK1	ENSMODP00000059879	ENSMODP00000059243	TAN domain-containing protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.987
ATM	CHEK2	ENSMODP00000059879	ENSMODP00000010421	TAN domain-containing protein.	Checkpoint kinase 2.	0.997
ATM	COP1	ENSMODP00000059879	ENSMODP00000006906	TAN domain-containing protein.	COP1 E3 ubiquitin ligase.	0.608