STRINGSTRING
DDIT4 DDIT4 LOC100024773 LOC100024773 WNT2B WNT2B PIK3R3 PIK3R3 IGF1 IGF1 DVL3 DVL3 PRKAA2 PRKAA2 RNF152 RNF152 RPS6 RPS6 FZD4 FZD4 PRKCA PRKCA LAMTOR4 LAMTOR4 FLCN FLCN EIF4E1B EIF4E1B SEC13 SEC13 WNT11 WNT11 FZD6 FZD6 RAF1 RAF1 DVL1 DVL1 DVL2 DVL2 AKT3 AKT3 FZD8 FZD8 RPS6KB1 RPS6KB1 CASTOR2 CASTOR2 WNT7B WNT7B GRB2 GRB2 RPS6KB2 RPS6KB2 AKT2 AKT2 LAMTOR1 LAMTOR1 RPS6KA3 RPS6KA3 WNT7A WNT7A FZD3 FZD3 SOS1 SOS1 GRB10 GRB10 MAP2K1 MAP2K1 ATP6V1B2 ATP6V1B2 DEPDC5 DEPDC5 ATP6V1D ATP6V1D IKBKB IKBKB LPIN1 LPIN1 FZD1 FZD1 CHUK CHUK CAB39 CAB39 SESN2 SESN2 ULK2 ULK2 CAB39L CAB39L ATP6V1B1 ATP6V1B1 RRAGB RRAGB FZD2 FZD2 SOS2 SOS2 NPRL2 NPRL2 TSC1 TSC1 ATP6V1G3 ATP6V1G3 AKT1 AKT1 FZD9 FZD9 WNT3A WNT3A FNIP1 FNIP1 RPS6KA6 RPS6KA6 INSR INSR STRADB STRADB WNT6 WNT6 WNT16 WNT16 MAPK3 MAPK3 WNT2 WNT2 MLST8 MLST8 FZD5 FZD5 TSC2 TSC2 TELO2 TELO2 FZD7 FZD7 NPRL3 NPRL3 WDR24 WDR24 F6VMH3_MONDO F6VMH3_MONDO RRAGC RRAGC MAPK1 MAPK1 TNFRSF1A TNFRSF1A ATP6V1A ATP6V1A LRP6 LRP6 RRAGD RRAGD WNT5A WNT5A ATP6V1E1 ATP6V1E1 F7FNN8_MONDO F7FNN8_MONDO ATP6V1G1 ATP6V1G1 PIK3R1 PIK3R1 MAPKAP1 MAPKAP1 PRKAA1 PRKAA1 RICTOR RICTOR SKP2 SKP2 LAMTOR3 LAMTOR3 EIF4E EIF4E PIK3CA PIK3CA EIF4E2 EIF4E2 BRAF BRAF LOC100022215 LOC100022215 IRS1 IRS1 WNT10A WNT10A KRAS-2 KRAS-2 DEPTOR DEPTOR LOC103094341 LOC103094341 STK11 STK11 WNT9B WNT9B ATP6V1C1 ATP6V1C1 WNT3 WNT3 LPIN3 LPIN3 LAMTOR2 LAMTOR2 TBC1D7 TBC1D7 PRKCB PRKCB CLIP1 CLIP1 RPS6KA2 RPS6KA2 SEH1L SEH1L SLC7A5 SLC7A5 RPS6KA1 RPS6KA1 LAMTOR5 LAMTOR5 PRR5 PRR5 NRAS NRAS TTI1 TTI1 ATP6V1F ATP6V1F RPTOR RPTOR WNT1 WNT1 SGK1 SGK1 WNT9A WNT9A EIF4EBP1 EIF4EBP1 PIK3CB PIK3CB WNT5B WNT5B SLC38A9 SLC38A9 SIRT6 SIRT6 WDR59 WDR59 RHEB RHEB ATP6V1H ATP6V1H FNIP2 FNIP2 WNT4 WNT4 WNT8B WNT8B RHOA RHOA AKT1S1 AKT1S1 ENSMODP00000057642 ENSMODP00000057642 MTOR MTOR CASTOR1 CASTOR1 SLC3A2 SLC3A2 IGF1R IGF1R FZD10 FZD10 GSK3B GSK3B HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDIT4DNA damage inducible transcript 4. (226 aa)
LOC100024773Uncharacterized protein. (227 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
IGF1Insulin like growth factor 1. (225 aa)
DVL3Dishevelled segment polarity protein 3. (635 aa)
PRKAA2Non-specific serine/threonine protein kinase. (551 aa)
RNF152Ring finger protein 152. (204 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (98 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
EIF4E1BUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (321 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
DVL1Dishevelled segment polarity protein 1. (705 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (710 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
CASTOR2Uncharacterized protein. (329 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (476 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (200 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
GRB10Growth factor receptor bound protein 10. (596 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (508 aa)
DEPDC5DEP domain-containing protein. (1366 aa)
ATP6V1DUncharacterized protein. (229 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (693 aa)
LPIN1Uncharacterized protein. (596 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CAB39Calcium binding protein 39. (341 aa)
SESN2Sestrin 2. (478 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1041 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (526 aa)
RRAGBRas related GTP binding B. (366 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1328 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
TSC1TSC complex subunit 1. (1152 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
FNIP1Folliculin interacting protein 1. (1214 aa)
RPS6KA6Ribosomal protein S6 kinase. (771 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
STRADBSTE20 related adaptor beta. (425 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
TSC2TSC complex subunit 2. (1830 aa)
TELO2Telomere maintenance 2. (808 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (579 aa)
WDR24WD repeat domain 24. (788 aa)
F6VMH3_MONDOUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (169 aa)
RRAGCRas related GTP binding C. (404 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
TNFRSF1AUncharacterized protein. (453 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
RRAGDRas related GTP binding D. (401 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
ATP6V1E1Uncharacterized protein. (226 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1735 aa)
SKP2S-phase kinase associated protein 2. (422 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (235 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (248 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (563 aa)
LOC100022215V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (378 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
DEPTORDEP domain containing MTOR interacting protein. (420 aa)
LOC103094341V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (114 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (414 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (427 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (431 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
LPIN3LNS2 domain-containing protein. (741 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (145 aa)
TBC1D7TBC1 domain family member 7. (300 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
CLIP1CAP-Gly domain containing linker protein 1. (1431 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (426 aa)
SLC7A5Solute carrier family 7 member 5. (533 aa)
RPS6KA1Ribosomal protein S6 kinase. (740 aa)
LAMTOR5Uncharacterized protein. (93 aa)
PRR5Uncharacterized protein. (408 aa)
NRASGTPase NRas. (195 aa)
TTI1TELO2 interacting protein 1. (1089 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1225 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
SGK1Non-specific serine/threonine protein kinase. (524 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
EIF4EBP1Uncharacterized protein. (273 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (447 aa)
SLC38A9Solute carrier family 38 member 9. (559 aa)
SIRT6Uncharacterized protein. (547 aa)
WDR59WD repeat domain 59. (1107 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (501 aa)
FNIP2Folliculin interacting protein 2. (1170 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
RHOAUncharacterized protein. (193 aa)
AKT1S1Uncharacterized protein. (167 aa)
ENSMODP00000057642Uncharacterized protein. (367 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (331 aa)
SLC3A2Solute carrier family 3 member 2. (589 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (444 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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