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ADCY8 ADCY8 ADCY2 ADCY2 PIK3R3 PIK3R3 IGF1 IGF1 ADCY4 ADCY4 PRKAA2 PRKAA2 PRKAG2 PRKAG2 HSPA1A HSPA1A FOXA2 FOXA2 AKT3 AKT3 RPS6KB1 RPS6KB1 SOD2 SOD2 RPS6KB2 RPS6KB2 AKT2 AKT2 FOXO1 FOXO1 EIF4EBP2 EIF4EBP2 ADCY7 ADCY7 AKT1 AKT1 INSR INSR PRKAB1 PRKAB1 PRKAG3 PRKAG3 PRKAG1 PRKAG1 ADCY3 ADCY3 ADCY9 ADCY9 SIRT1 SIRT1 HDAC1 HDAC1 HDAC2 HDAC2 FOXO3 FOXO3 F7FNN8_MONDO F7FNN8_MONDO PIK3R1 PIK3R1 PRKAA1 PRKAA1 SOD1 SOD1 PIK3CA PIK3CA IRS1 IRS1 IRS2 IRS2 LOC100011711 LOC100011711 LOC100015032 LOC100015032 KRAS-2 KRAS-2 ADCY1 ADCY1 NRAS NRAS PRKACA PRKACA PRKAB2 PRKAB2 RPTOR RPTOR CAT CAT PIK3CB PIK3CB HSPA8 HSPA8 AKT1S1 AKT1S1 MTOR MTOR ATG5 ATG5 IGF1R IGF1R CRYAB CRYAB HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
IGF1Insulin like growth factor 1. (225 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
PRKAA2Non-specific serine/threonine protein kinase. (551 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (580 aa)
HSPA1AUncharacterized protein; Belongs to the heat shock protein 70 family. (722 aa)
FOXA2Forkhead box A2. (459 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (523 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (476 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
FOXO1Forkhead box O1. (670 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (122 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
PRKAB1AMPKBI domain-containing protein. (273 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (471 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (310 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (713 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (450 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
FOXO3Fork-head domain-containing protein. (697 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (177 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
IRS2Insulin receptor substrate 2. (1384 aa)
LOC100011711Uncharacterized protein; Belongs to the heat shock protein 70 family. (644 aa)
LOC100015032Uncharacterized protein; Belongs to the heat shock protein 70 family. (644 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
NRASGTPase NRas. (195 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
PRKAB2AMPKBI domain-containing protein. (106 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1225 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (529 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (648 aa)
AKT1S1Uncharacterized protein. (167 aa)
MTORSerine/threonine-protein kinase mTOR. (1040 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (277 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
CRYABCrystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (182 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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