STRINGSTRING
PLCB2 PLCB2 CREB3L3 CREB3L3 ATP2B4 ATP2B4 ADCY8 ADCY8 GNAI3 GNAI3 ADCY2 ADCY2 RPS6KA5 RPS6KA5 CALM1 CALM1 ATP1B1 ATP1B1 ADCY4 ADCY4 CACNG1 CACNG1 PRKCA PRKCA PLCB1 PLCB1 AGTR2 AGTR2 ADRB2 ADRB2 AKT3 AKT3 ATP1B2 ATP1B2 CREB3 CREB3 AKT2 AKT2 ADRA1B ADRA1B ATP2B3 ATP2B3 PIK3R5 PIK3R5 ACTC1 ACTC1 PPP2R5E PPP2R5E SLC8A1 SLC8A1 AGT AGT ATF4 ATF4 CALML4 CALML4 ATF2 ATF2 ADRB1 ADRB1 LOC100033060 LOC100033060 CACNB3 CACNB3 PPP2R2B PPP2R2B MYL2 MYL2 CACNB1 CACNB1 PPP2R3C PPP2R3C GNAQ GNAQ ADCY7 ADCY7 SCN5A SCN5A SCN4B SCN4B MAPK13 MAPK13 AKT1 AKT1 CREB3L2 CREB3L2 MYL3 MYL3 PPP2CA PPP2CA SLC9A1 SLC9A1 PPP2R1B PPP2R1B TPM4 TPM4 ATF6B ATF6B CREB5 CREB5 ADRA1D ADRA1D ATP2A1 ATP2A1 PPP1CB PPP1CB MAPK3 MAPK3 ADCY3 ADCY3 CAMK2B CAMK2B CACNG3 CACNG3 ADCY9 ADCY9 PIK3CG PIK3CG ADRA1A ADRA1A PPP2R2A PPP2R2A GNAI1 GNAI1 CREB3L4 CREB3L4 MAPK1 MAPK1 CACNA2D4 CACNA2D4 PPP2R3A PPP2R3A PPP2CB PPP2CB PPP2R2D PPP2R2D PPP2R1A PPP2R1A F7D7P9_MONDO F7D7P9_MONDO PLN PLN SLC8A2 SLC8A2 CALML3 CALML3 AGTR1 AGTR1 CACNA1S CACNA1S KCNE1 KCNE1 FXYD2 FXYD2 GNAI2 GNAI2 TPM2 TPM2 CREB3L1 CREB3L1 ENSMODP00000045422 ENSMODP00000045422 ADCY1 ADCY1 RYR2 RYR2 PPP1CC PPP1CC TPM3 TPM3 MAPK14 MAPK14 CACNA2D2 CACNA2D2 PLCB4 PLCB4 PRKACA PRKACA CACNB2 CACNB2 RAPGEF4 RAPGEF4 CACNA1C CACNA1C ATP2B1 ATP2B1 PPP2R5D PPP2R5D CACNA2D3 CACNA2D3 TNNC1 TNNC1 SLC8A3 SLC8A3 MAPK12 MAPK12 ATP2A2 ATP2A2 PPP2R5A PPP2R5A CACNA2D1-2 CACNA2D1-2 TNNT2 TNNT2 PPP2R3B PPP2R3B CAMK2D CAMK2D CACNB4 CACNB4 CREB1 CREB1 MYH6 MYH6 ENSMODP00000059741 ENSMODP00000059741 GNAS GNAS TPM1 TPM1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (508 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1058 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
GNAI3G protein subunit alpha i3. (399 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
RPS6KA5Ribosomal protein S6 kinase. (795 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (304 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (383 aa)
ADRB2Adrenoceptor beta 2. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
CREB3BZIP domain-containing protein. (370 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
ADRA1BAdrenoceptor alpha 1B. (505 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1073 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (873 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (627 aa)
AGTAngiotensinogen; Belongs to the serpin family. (469 aa)
ATF4Activating transcription factor 4. (346 aa)
CALML4Calmodulin like 4. (156 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ADRB1Adrenoceptor beta 1. (505 aa)
LOC100033060Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1099 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (482 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (484 aa)
MYL2Myosin light chain 2. (166 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (605 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (449 aa)
GNAQG protein subunit alpha q. (359 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1839 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (230 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (518 aa)
MYL3Myosin light chain 3. (197 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (392 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (627 aa)
TPM4Uncharacterized protein; Belongs to the tropomyosin family. (248 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (504 aa)
ADRA1DAdrenoceptor alpha 1D. (555 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (948 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (671 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1099 aa)
ADRA1AAdrenoceptor alpha 1A. (465 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (419 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (360 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
CACNA2D4VWFA domain-containing protein. (330 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1155 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (417 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (410 aa)
F7D7P9_MONDOUncharacterized protein; Belongs to the calmodulin family. (65 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
SLC8A2Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (431 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
KCNE1Uncharacterized protein. (126 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (123 aa)
GNAI2G protein subunit alpha i2. (315 aa)
TPM2Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (535 aa)
ENSMODP00000045422Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (763 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
RYR2Ryanodine receptor 2. (4900 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
TPM3Tropomyosin 3; Belongs to the tropomyosin family. (285 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CACNA2D2Uncharacterized protein. (484 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (612 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (912 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2123 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (997 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (191 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (496 aa)
CACNA2D1-2Uncharacterized protein. (105 aa)
TNNT2Troponin T2, cardiac type. (355 aa)
PPP2R3BEF-hand domain-containing protein. (581 aa)
CAMK2DProtein kinase domain-containing protein. (145 aa)
CACNB4SH3 domain-containing protein. (520 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1943 aa)
ENSMODP00000059741Uncharacterized protein. (70 aa)
GNASUncharacterized protein. (370 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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