STRINGSTRING
SRC SRC PLCG1 PLCG1 RAC2 RAC2 PIK3R3 PIK3R3 RAC3 RAC3 PRKCA PRKCA RAF1 RAF1 AKT3 AKT3 AKT2 AKT2 PPP3CC PPP3CC MAP2K1 MAP2K1 PTGS2 PTGS2 MAPKAPK3 MAPKAPK3 PLA2G4C PLA2G4C HSPB1 HSPB1 MAPK13 MAPK13 AKT1 AKT1 PLCG2 PLCG2 MAPK3 MAPK3 MAPK1 MAPK1 PLA2G4E PLA2G4E VEGFA VEGFA F7FNN8_MONDO F7FNN8_MONDO PIK3R1 PIK3R1 KDR KDR PPP3CA PPP3CA PIK3CA PIK3CA CDC42 CDC42 F7CI75_MONDO F7CI75_MONDO NOS3 NOS3 KRAS-2 KRAS-2 BAD BAD SPHK1 SPHK1 PPP3CB PPP3CB PRKCB PRKCB MAPK14 MAPK14 NRAS NRAS NFATC2 NFATC2 PTK2 PTK2 SH2D2A SH2D2A PIK3CB PIK3CB MAPK12 MAPK12 SIRT6 SIRT6 F7GAG3_MONDO F7GAG3_MONDO HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (550 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1292 aa)
RAC2Rac family small GTPase 2. (281 aa)
PIK3R3SH2 domain-containing protein. (276 aa)
RAC3Rac family small GTPase 3. (192 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (666 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT2AKT serine/threonine kinase 2; Belongs to the protein kinase superfamily. (498 aa)
PPP3CCSerine/threonine-protein phosphatase. (517 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (608 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (395 aa)
PLA2G4CPLA2c domain-containing protein. (204 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (256 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
PLA2G4EPhospholipase A2. (868 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
F7FNN8_MONDOUncharacterized protein. (199 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CDC42Cell division cycle 42. (191 aa)
F7CI75_MONDOUncharacterized protein. (223 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
KRAS-2GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity); Belongs to the small GTPase superfamily. Ras family. (194 aa)
BADUncharacterized protein. (212 aa)
SPHK1Sphingosine kinase 1. (454 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (641 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NRASGTPase NRas. (195 aa)
NFATC2Nuclear factor of activated T cells 2. (927 aa)
PTK2Uncharacterized protein. (161 aa)
SH2D2ASH2 domain-containing protein. (427 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
SIRT6Uncharacterized protein. (547 aa)
F7GAG3_MONDOPLA2c domain-containing protein. (590 aa)
HRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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